Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

Aims/hypothesis Chronic hyperglycaemia aggravates insulin resistance, at least in part, by increasing the formation of advanced glycation end-products (AGEs). Methylglyoxal (MGO) is the most reactive AGE precursor and its abnormal accumulation participates in damage in various tissues and organs. He...

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Veröffentlicht in:	Diabetologia 2011-11, Vol.54 (11), p.2941-2952
Hauptverfasser:	Fiory, F., Lombardi, A., Miele, C., Giudicelli, J., Beguinot, F., Van Obberghen, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Cell Line Cells Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gene expression Gene Expression Regulation - drug effects Glucokinase - genetics Glucokinase - metabolism Glucose Glucose - metabolism Glycation End Products, Advanced - metabolism Glycogen Synthase Kinase 3 - antagonists & inhibitors Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human Physiology Hyperglycemia Insulin - genetics Insulin - metabolism Insulin Receptor Substrate Proteins Insulin resistance Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Internal Medicine Kinases Medical sciences Medicine Medicine & Public Health Metabolic Diseases Pathogenesis Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Protein Processing, Post-Translational - drug effects Proteins Pyruvaldehyde - metabolism Rats Reactive Oxygen Species - metabolism RNA, Messenger - metabolism Secretory Pathway - drug effects Signal Transduction - drug effects Trans-Activators - genetics Trans-Activators - metabolism
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