Quinoprotein Adducts Accumulate in the Substantia Nigra of Aged Rats and Correlate with Dopamine-Induced Toxicity in SH-SY5Y Cells

Parkinson’s disease (PD) is an age-dependent neurodegenerative disorder characterized by dopaminergic neuron loss in substantia nigra. Previous studies have implicated a role of dopamine oxidation in PD. Dopamine oxidation leads to the formation of dopamine quinone, which generates reactive oxygen s...

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Veröffentlicht in:	Neurochemical research 2011-11, Vol.36 (11), p.2169-2175
Hauptverfasser:	Wang, Na, Wang, Yan, Yu, Guohua, Yuan, Chonggang, Ma, Jiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cysteine - analogs & derivatives Cysteine - metabolism Dopamine - analogs & derivatives Dopamine - metabolism Dopamine - toxicity Dopamine Antagonists - pharmacology Dopaminergic Neurons - physiology Humans Hydroquinones - metabolism Isothiocyanates Lipid Peroxidation - physiology Male Nerve Tissue Proteins - metabolism Neurochemistry Neurology Neurosciences Original Paper Rats Rats, Sprague-Dawley Substantia Nigra - drug effects Substantia Nigra - metabolism Thiocyanates - pharmacology Tumor Cells, Cultured
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