Relationship between muscle T^sub 2^^sup ^ relaxation properties and metabolic state: a combined localized ^sup 31^P-spectroscopy and ^sup 1^H-imaging study
A multi-volume ^sup 31^P-magnetic resonance spectroscopy localization procedure was implemented to compare directly muscle metabolism and proton T^sub 2^ ^sup *^ relaxation properties in the human plantar flexor muscles during exercise. Localized ^sup 31^P-spectra were collected simultaneously from...
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| Veröffentlicht in: | European journal of applied physiology 2000-05, Vol.82 (1-2), p.76 |
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| creator | Vandenborne, Krista Walter, Glenn Ploutz-snyder, Lori Dudley, Gary Elliott, Mark A De Meirleir, Kenny |
| description | A multi-volume ^sup 31^P-magnetic resonance spectroscopy localization procedure was implemented to compare directly muscle metabolism and proton T^sub 2^ ^sup *^ relaxation properties in the human plantar flexor muscles during exercise. Localized ^sup 31^P-spectra were collected simultaneously from the medial gastrocnemius, lateral gastrocnemius and soleus muscles during exercise using β ^sub 1^-insensitive Hadamard Spectroscopic Imaging (HSI). ^sup 1^H T^sub 2^ ^sup *^-weighted gradient-echo images were acquired at rest and immediately following high-intensity plantar flexion exercise. T^sub 2^ ^sup *^ mapping of the individual calf muscles showed that plantar flexion with the knee extended produces significant increases (P |
| doi_str_mv | 10.1007/s004210050654 |
| format | Article |
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Localized ^sup 31^P-spectra were collected simultaneously from the medial gastrocnemius, lateral gastrocnemius and soleus muscles during exercise using β ^sub 1^-insensitive Hadamard Spectroscopic Imaging (HSI). ^sup 1^H T^sub 2^ ^sup *^-weighted gradient-echo images were acquired at rest and immediately following high-intensity plantar flexion exercise. T^sub 2^ ^sup *^ mapping of the individual calf muscles showed that plantar flexion with the knee extended produces significant increases (P<0.0001) in the mean (SEM) T^sub 2^ ^sup *^ of the medial [35.6 (1.2)ms vs 28.5 (0.5)ms at rest] and lateral gastrocnemius [35.6 (0.9)ms vs 26.2 (0.9)ms at rest], but not in the soleus [26.7 (0.6)ms vs 27.3 (0.8)ms at rest]. In accordance with the changes in T^sub 2^ ^sup *^, the ratio of inorganic phosphate to phosphocreatine (P^sub i^:PCr) and the intracellular muscle pH shifted significantly in the gastrocnemii, while the soleus showed no change in muscle pH and only a moderate increase in P^sub i^-to-Ph. Comparison of spectroscopic and relaxation parameters in both gastrocnemius muscles revealed a significant relationship between post-exercise T^sub 2^ ^sup *^ and intracellular pH (r=0.72-0.76) and P^sub i^-to-Ph ratios (r=0.81-0.88) during exercise. Using an improved method of localization, this study confirms the existence of a strong relationship between transverse relaxation properties and the metabolic state in skeletal muscles engaged in heavy exercise.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s004210050654</identifier><language>eng</language><publisher>Heidelberg: Springer Nature B.V</publisher><subject>Hypotheses ; Localization ; Magnetic resonance imaging ; Medical research ; Metabolism ; Musculoskeletal system ; Protons ; Spectrum analysis</subject><ispartof>European journal of applied physiology, 2000-05, Vol.82 (1-2), p.76</ispartof><rights>Springer-Verlag Berlin Heidelberg 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Vandenborne, Krista</creatorcontrib><creatorcontrib>Walter, Glenn</creatorcontrib><creatorcontrib>Ploutz-snyder, Lori</creatorcontrib><creatorcontrib>Dudley, Gary</creatorcontrib><creatorcontrib>Elliott, Mark A</creatorcontrib><creatorcontrib>De Meirleir, Kenny</creatorcontrib><title>Relationship between muscle T^sub 2^^sup ^ relaxation properties and metabolic state: a combined localized ^sup 31^P-spectroscopy and ^sup 1^H-imaging study</title><title>European journal of applied physiology</title><description>A multi-volume ^sup 31^P-magnetic resonance spectroscopy localization procedure was implemented to compare directly muscle metabolism and proton T^sub 2^ ^sup *^ relaxation properties in the human plantar flexor muscles during exercise. Localized ^sup 31^P-spectra were collected simultaneously from the medial gastrocnemius, lateral gastrocnemius and soleus muscles during exercise using β ^sub 1^-insensitive Hadamard Spectroscopic Imaging (HSI). ^sup 1^H T^sub 2^ ^sup *^-weighted gradient-echo images were acquired at rest and immediately following high-intensity plantar flexion exercise. T^sub 2^ ^sup *^ mapping of the individual calf muscles showed that plantar flexion with the knee extended produces significant increases (P<0.0001) in the mean (SEM) T^sub 2^ ^sup *^ of the medial [35.6 (1.2)ms vs 28.5 (0.5)ms at rest] and lateral gastrocnemius [35.6 (0.9)ms vs 26.2 (0.9)ms at rest], but not in the soleus [26.7 (0.6)ms vs 27.3 (0.8)ms at rest]. In accordance with the changes in T^sub 2^ ^sup *^, the ratio of inorganic phosphate to phosphocreatine (P^sub i^:PCr) and the intracellular muscle pH shifted significantly in the gastrocnemii, while the soleus showed no change in muscle pH and only a moderate increase in P^sub i^-to-Ph. Comparison of spectroscopic and relaxation parameters in both gastrocnemius muscles revealed a significant relationship between post-exercise T^sub 2^ ^sup *^ and intracellular pH (r=0.72-0.76) and P^sub i^-to-Ph ratios (r=0.81-0.88) during exercise. Using an improved method of localization, this study confirms the existence of a strong relationship between transverse relaxation properties and the metabolic state in skeletal muscles engaged in heavy exercise.[PUBLICATION ABSTRACT]</description><subject>Hypotheses</subject><subject>Localization</subject><subject>Magnetic resonance imaging</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Musculoskeletal system</subject><subject>Protons</subject><subject>Spectrum analysis</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNjctOwzAURC1EJcpjyf6KfcB20jzYIlCXFeo6lePcFleObXIdQfkWPhYrQqxZzZHmaIaxW8HvBefVA3FeyEQrXq6KM7YURd5kZS6r8z8WzQW7JDpyzmsp6iX7fkWrovGO3kyADuMHooNhIm0Rti1NHcg2RYAWxqR-zjKE0Qcco0EC5XoYMKrOW6OBoor4CAq0HzrjsAfrtbLmK9E8k4t2k1FAHUdP2ofTPDBXol1nZlAH4w5pZ-pP12yxV5bw5jev2N3L8_ZpnaX79wkp7o5-Gl2qdnWTV7JsZJH_S_oBUOBgew</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Vandenborne, Krista</creator><creator>Walter, Glenn</creator><creator>Ploutz-snyder, Lori</creator><creator>Dudley, Gary</creator><creator>Elliott, Mark A</creator><creator>De Meirleir, Kenny</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20000501</creationdate><title>Relationship between muscle T^sub 2^^sup ^ relaxation properties and metabolic state: a combined localized ^sup 31^P-spectroscopy and ^sup 1^H-imaging study</title><author>Vandenborne, Krista ; Walter, Glenn ; Ploutz-snyder, Lori ; Dudley, Gary ; Elliott, Mark A ; De Meirleir, Kenny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_8937269243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Hypotheses</topic><topic>Localization</topic><topic>Magnetic resonance imaging</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Musculoskeletal system</topic><topic>Protons</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vandenborne, Krista</creatorcontrib><creatorcontrib>Walter, Glenn</creatorcontrib><creatorcontrib>Ploutz-snyder, Lori</creatorcontrib><creatorcontrib>Dudley, Gary</creatorcontrib><creatorcontrib>Elliott, Mark A</creatorcontrib><creatorcontrib>De Meirleir, Kenny</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vandenborne, Krista</au><au>Walter, Glenn</au><au>Ploutz-snyder, Lori</au><au>Dudley, Gary</au><au>Elliott, Mark A</au><au>De Meirleir, Kenny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between muscle T^sub 2^^sup ^ relaxation properties and metabolic state: a combined localized ^sup 31^P-spectroscopy and ^sup 1^H-imaging study</atitle><jtitle>European journal of applied physiology</jtitle><date>2000-05-01</date><risdate>2000</risdate><volume>82</volume><issue>1-2</issue><spage>76</spage><pages>76-</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>A multi-volume ^sup 31^P-magnetic resonance spectroscopy localization procedure was implemented to compare directly muscle metabolism and proton T^sub 2^ ^sup *^ relaxation properties in the human plantar flexor muscles during exercise. Localized ^sup 31^P-spectra were collected simultaneously from the medial gastrocnemius, lateral gastrocnemius and soleus muscles during exercise using β ^sub 1^-insensitive Hadamard Spectroscopic Imaging (HSI). ^sup 1^H T^sub 2^ ^sup *^-weighted gradient-echo images were acquired at rest and immediately following high-intensity plantar flexion exercise. T^sub 2^ ^sup *^ mapping of the individual calf muscles showed that plantar flexion with the knee extended produces significant increases (P<0.0001) in the mean (SEM) T^sub 2^ ^sup *^ of the medial [35.6 (1.2)ms vs 28.5 (0.5)ms at rest] and lateral gastrocnemius [35.6 (0.9)ms vs 26.2 (0.9)ms at rest], but not in the soleus [26.7 (0.6)ms vs 27.3 (0.8)ms at rest]. In accordance with the changes in T^sub 2^ ^sup *^, the ratio of inorganic phosphate to phosphocreatine (P^sub i^:PCr) and the intracellular muscle pH shifted significantly in the gastrocnemii, while the soleus showed no change in muscle pH and only a moderate increase in P^sub i^-to-Ph. Comparison of spectroscopic and relaxation parameters in both gastrocnemius muscles revealed a significant relationship between post-exercise T^sub 2^ ^sup *^ and intracellular pH (r=0.72-0.76) and P^sub i^-to-Ph ratios (r=0.81-0.88) during exercise. Using an improved method of localization, this study confirms the existence of a strong relationship between transverse relaxation properties and the metabolic state in skeletal muscles engaged in heavy exercise.[PUBLICATION ABSTRACT]</abstract><cop>Heidelberg</cop><pub>Springer Nature B.V</pub><doi>10.1007/s004210050654</doi></addata></record> |
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| subjects | Hypotheses Localization Magnetic resonance imaging Medical research Metabolism Musculoskeletal system Protons Spectrum analysis |
| title | Relationship between muscle T^sub 2^^sup ^ relaxation properties and metabolic state: a combined localized ^sup 31^P-spectroscopy and ^sup 1^H-imaging study |
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