Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations
Purpose Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Materials and methods We performed...
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| Veröffentlicht in: | International journal of colorectal disease 2011-10, Vol.26 (10), p.1249-1255 |
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| container_title | International journal of colorectal disease |
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| creator | Zhang, Lou-Qian Wang, Jun Shang, Jun-Qing Bai, Jian-ling Liu, Fu-Yin Guan, Xin Zhou, Jian-Nong |
| description | Purpose
Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed.
Materials and methods
We performed an extensive search of relevant studies and carried out a meta-analysis, including 20 studies with 5,975 cases and 8,333 controls, to obtain a more precise estimate.
Results
Overall, significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95% CI = 1.04–1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01–1.26; dominant model: OR = 1.16, 95% CI = 1.03–1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95% CI = 1.04–1.44; dominant model: OR = 1.17, 95% CI = 1.02–1.34).We also observed sporadic CRC with an increased cancer susceptibility (AA vs. GG: OR = 1.24, 95% CI = 1.04–1.48; dominant model: OR = 1.17, 95% CI = 1.04–1.33), when colorectal cancer was stratified into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC). However, no significant associations were found in both Asians and HNPCC patients for all genetic models.
Conclusion
Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians. |
| doi_str_mv | 10.1007/s00384-011-1220-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_893215448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714491579</galeid><sourcerecordid>A714491579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-44ce9e7d86f6b7232e2f9dcf2e0bab89201b83e9c44d9d0fa34f1088f8792a0b3</originalsourceid><addsrcrecordid>eNp1kVFv1SAUx4nRuOv0A_hiiMbHbkBpAd9urjqXLPFFnwmlMFloqZw2Wb_92Hp1MXHhgQC__-Gc_BB6S8kZJUScAyG15BWhtKKMker2GdpRXrNyatlztCNUqIqqRp6gVwA3pJxbwV-iE0YbzkUtdqg_rDaGEX-m-EIKssdTiuuQ8vQrwIDN2GObYsrOziZia0brMoYFrJvm0IUY5vUTNnhws6nMaOIKAXDymJFSaFqimUMa4TV64U0E9-a4n6KfX7_8OHyrrr5fXB72V5XlrZgrzq1TTvSy9W0nWM0c86q3njnSmU4qRmgna6cs573qiTc195RI6aVQzJCuPkXvt7pTTr8XB7O-SUsubYGWqn4YWhbowwZdm-h0GH2as7FDAKv3gnKuaCNUoc7-Q5XVuyHYNDofyv0_AboFbE4A2Xk95TCYvGpK9L0tvdnSxZa-t6VvS-bdsd-lG1z_N_FHTwE-HgED1kSfi4AAjxxvGsI4LxzbOChP47XLj4M__fsdZOyrBg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>893215448</pqid></control><display><type>article</type><title>Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Zhang, Lou-Qian ; Wang, Jun ; Shang, Jun-Qing ; Bai, Jian-ling ; Liu, Fu-Yin ; Guan, Xin ; Zhou, Jian-Nong</creator><creatorcontrib>Zhang, Lou-Qian ; Wang, Jun ; Shang, Jun-Qing ; Bai, Jian-ling ; Liu, Fu-Yin ; Guan, Xin ; Zhou, Jian-Nong</creatorcontrib><description>Purpose
Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed.
Materials and methods
We performed an extensive search of relevant studies and carried out a meta-analysis, including 20 studies with 5,975 cases and 8,333 controls, to obtain a more precise estimate.
Results
Overall, significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95% CI = 1.04–1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01–1.26; dominant model: OR = 1.16, 95% CI = 1.03–1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95% CI = 1.04–1.44; dominant model: OR = 1.17, 95% CI = 1.02–1.34).We also observed sporadic CRC with an increased cancer susceptibility (AA vs. GG: OR = 1.24, 95% CI = 1.04–1.48; dominant model: OR = 1.17, 95% CI = 1.04–1.33), when colorectal cancer was stratified into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC). However, no significant associations were found in both Asians and HNPCC patients for all genetic models.
Conclusion
Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-011-1220-x</identifier><identifier>PMID: 21544737</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Amino Acid Substitution - genetics ; Analysis ; Biological and medical sciences ; Cancer ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Cyclin D1 - genetics ; Development and progression ; Disease susceptibility ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genetics, Population ; Health aspects ; Hepatology ; Humans ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Odds Ratio ; Oncology, Experimental ; Original Article ; Polymorphism, Single Nucleotide - genetics ; Proctology ; Publication Bias ; Risk Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Tumors</subject><ispartof>International journal of colorectal disease, 2011-10, Vol.26 (10), p.1249-1255</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-44ce9e7d86f6b7232e2f9dcf2e0bab89201b83e9c44d9d0fa34f1088f8792a0b3</citedby><cites>FETCH-LOGICAL-c467t-44ce9e7d86f6b7232e2f9dcf2e0bab89201b83e9c44d9d0fa34f1088f8792a0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-011-1220-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-011-1220-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24550244$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21544737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lou-Qian</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Shang, Jun-Qing</creatorcontrib><creatorcontrib>Bai, Jian-ling</creatorcontrib><creatorcontrib>Liu, Fu-Yin</creatorcontrib><creatorcontrib>Guan, Xin</creatorcontrib><creatorcontrib>Zhou, Jian-Nong</creatorcontrib><title>Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose
Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed.
Materials and methods
We performed an extensive search of relevant studies and carried out a meta-analysis, including 20 studies with 5,975 cases and 8,333 controls, to obtain a more precise estimate.
Results
Overall, significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95% CI = 1.04–1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01–1.26; dominant model: OR = 1.16, 95% CI = 1.03–1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95% CI = 1.04–1.44; dominant model: OR = 1.17, 95% CI = 1.02–1.34).We also observed sporadic CRC with an increased cancer susceptibility (AA vs. GG: OR = 1.24, 95% CI = 1.04–1.48; dominant model: OR = 1.17, 95% CI = 1.04–1.33), when colorectal cancer was stratified into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC). However, no significant associations were found in both Asians and HNPCC patients for all genetic models.
Conclusion
Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians.</description><subject>Amino Acid Substitution - genetics</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Cyclin D1 - genetics</subject><subject>Development and progression</subject><subject>Disease susceptibility</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics, Population</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Odds Ratio</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Proctology</subject><subject>Publication Bias</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kVFv1SAUx4nRuOv0A_hiiMbHbkBpAd9urjqXLPFFnwmlMFloqZw2Wb_92Hp1MXHhgQC__-Gc_BB6S8kZJUScAyG15BWhtKKMker2GdpRXrNyatlztCNUqIqqRp6gVwA3pJxbwV-iE0YbzkUtdqg_rDaGEX-m-EIKssdTiuuQ8vQrwIDN2GObYsrOziZia0brMoYFrJvm0IUY5vUTNnhws6nMaOIKAXDymJFSaFqimUMa4TV64U0E9-a4n6KfX7_8OHyrrr5fXB72V5XlrZgrzq1TTvSy9W0nWM0c86q3njnSmU4qRmgna6cs573qiTc195RI6aVQzJCuPkXvt7pTTr8XB7O-SUsubYGWqn4YWhbowwZdm-h0GH2as7FDAKv3gnKuaCNUoc7-Q5XVuyHYNDofyv0_AboFbE4A2Xk95TCYvGpK9L0tvdnSxZa-t6VvS-bdsd-lG1z_N_FHTwE-HgED1kSfi4AAjxxvGsI4LxzbOChP47XLj4M__fsdZOyrBg</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Zhang, Lou-Qian</creator><creator>Wang, Jun</creator><creator>Shang, Jun-Qing</creator><creator>Bai, Jian-ling</creator><creator>Liu, Fu-Yin</creator><creator>Guan, Xin</creator><creator>Zhou, Jian-Nong</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20111001</creationdate><title>Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations</title><author>Zhang, Lou-Qian ; Wang, Jun ; Shang, Jun-Qing ; Bai, Jian-ling ; Liu, Fu-Yin ; Guan, Xin ; Zhou, Jian-Nong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-44ce9e7d86f6b7232e2f9dcf2e0bab89201b83e9c44d9d0fa34f1088f8792a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino Acid Substitution - genetics</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Cyclin D1 - genetics</topic><topic>Development and progression</topic><topic>Disease susceptibility</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics, Population</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Odds Ratio</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Proctology</topic><topic>Publication Bias</topic><topic>Risk Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lou-Qian</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Shang, Jun-Qing</creatorcontrib><creatorcontrib>Bai, Jian-ling</creatorcontrib><creatorcontrib>Liu, Fu-Yin</creatorcontrib><creatorcontrib>Guan, Xin</creatorcontrib><creatorcontrib>Zhou, Jian-Nong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lou-Qian</au><au>Wang, Jun</au><au>Shang, Jun-Qing</au><au>Bai, Jian-ling</au><au>Liu, Fu-Yin</au><au>Guan, Xin</au><au>Zhou, Jian-Nong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>26</volume><issue>10</issue><spage>1249</spage><epage>1255</epage><pages>1249-1255</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Purpose
Studies investigating the association between genetic polymorphism of cyclin D1 (CCND1) G870A and risk of colorectal cancer (CRC) reported conflicting results. In order to derive a more precise estimation of the relationship, a meta-analysis was performed.
Materials and methods
We performed an extensive search of relevant studies and carried out a meta-analysis, including 20 studies with 5,975 cases and 8,333 controls, to obtain a more precise estimate.
Results
Overall, significantly elevated colorectal cancer risk was associated with variant allele 870A when all studies were pooled (AA vs. GG: OR = 1.23, 95% CI = 1.04–1.44; GA vs. GG: OR = 1.13, 95% CI = 1.01–1.26; dominant model: OR = 1.16, 95% CI = 1.03–1.31). In the subgroup analysis by ethnicity, significantly increased risks were detected among Caucasians (AA vs. GG: OR = 1.27, 95% CI = 1.04–1.44; dominant model: OR = 1.17, 95% CI = 1.02–1.34).We also observed sporadic CRC with an increased cancer susceptibility (AA vs. GG: OR = 1.24, 95% CI = 1.04–1.48; dominant model: OR = 1.17, 95% CI = 1.04–1.33), when colorectal cancer was stratified into sporadic CRC and hereditary nonpolyposis colorectal cancer (HNPCC). However, no significant associations were found in both Asians and HNPCC patients for all genetic models.
Conclusion
Result suggests that the cyclin D1 870A allele is a low-penetrant risk factor for developing sporadic colorectal cancer, especially among Caucasians.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21544737</pmid><doi>10.1007/s00384-011-1220-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Amino Acid Substitution - genetics Analysis Biological and medical sciences Cancer Colorectal cancer Colorectal Neoplasms - genetics Cyclin D1 - genetics Development and progression Disease susceptibility Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genetics, Population Health aspects Hepatology Humans Internal Medicine Medical sciences Medicine Medicine & Public Health Odds Ratio Oncology, Experimental Original Article Polymorphism, Single Nucleotide - genetics Proctology Publication Bias Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Tumors |
| title | Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations |
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