Serum Parathyroid Hormone Levels in Chronic Endemic Fluorosis
Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of e...
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| Veröffentlicht in: | Biological trace element research 2011-10, Vol.143 (1), p.79-86 |
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| description | Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of excess parathyroid hormone (PTH) and fluorosis on bone. So fluoride might show its effect via PTH. We aimed to determine PTH levels in patients with endemic fluorosis to estimate the possible toxic effects of chronic fluoride intake. Fifty-six patients with endemic fluorosis and 28 age-, sex-, and body-mass-index-matched healthy controls were included in this study. Endemic fluorosis was diagnosed according to the clinical diagnosis criteria of Wang. The urine fluoride levels of fluorosis patients were significantly higher than those of control subjects as expected (1.9 ± 0.1 vs. 0.4 ± 0.1 mg/L, respectively;
P
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| doi_str_mv | 10.1007/s12011-010-8847-2 |
| format | Article |
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P
< 0.001). PTH levels in fluorosis group were significantly higher than control group (65.09 ± 32.91 versus 47.40 ± 20.37, respectively;
P
= 0.01). The results of our study demonstrate that serum PTH levels are increased in patients with endemic fluorosis. Fluoride, by interfering calcium balance, may be the cause of secondary hyperparathyroidism.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-010-8847-2</identifier><identifier>PMID: 20838920</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Adult ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Endocrine system ; Female ; Fluoride Poisoning - blood ; Fluorides ; Homeostasis ; Humans ; Life Sciences ; Male ; Nutrition ; Oncology ; Parathyroid Hormone - blood ; Public health ; Trace elements ; Turkey</subject><ispartof>Biological trace element research, 2011-10, Vol.143 (1), p.79-86</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-2ac922a58a005237232d7fcd4b2fd31e2de503719c449367d0c1587a022b45833</citedby><cites>FETCH-LOGICAL-c370t-2ac922a58a005237232d7fcd4b2fd31e2de503719c449367d0c1587a022b45833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-010-8847-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-010-8847-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20838920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koroglu, Banu Kale</creatorcontrib><creatorcontrib>Ersoy, Ismail Hakki</creatorcontrib><creatorcontrib>Koroglu, Mert</creatorcontrib><creatorcontrib>Balkarli, Ayşe</creatorcontrib><creatorcontrib>Ersoy, Siddika</creatorcontrib><creatorcontrib>Varol, Simge</creatorcontrib><creatorcontrib>Tamer, Mehmet Numan</creatorcontrib><title>Serum Parathyroid Hormone Levels in Chronic Endemic Fluorosis</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of excess parathyroid hormone (PTH) and fluorosis on bone. So fluoride might show its effect via PTH. We aimed to determine PTH levels in patients with endemic fluorosis to estimate the possible toxic effects of chronic fluoride intake. Fifty-six patients with endemic fluorosis and 28 age-, sex-, and body-mass-index-matched healthy controls were included in this study. Endemic fluorosis was diagnosed according to the clinical diagnosis criteria of Wang. The urine fluoride levels of fluorosis patients were significantly higher than those of control subjects as expected (1.9 ± 0.1 vs. 0.4 ± 0.1 mg/L, respectively;
P
< 0.001). PTH levels in fluorosis group were significantly higher than control group (65.09 ± 32.91 versus 47.40 ± 20.37, respectively;
P
= 0.01). The results of our study demonstrate that serum PTH levels are increased in patients with endemic fluorosis. Fluoride, by interfering calcium balance, may be the cause of secondary hyperparathyroidism.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Endocrine system</subject><subject>Female</subject><subject>Fluoride Poisoning - blood</subject><subject>Fluorides</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Parathyroid Hormone - blood</subject><subject>Public health</subject><subject>Trace elements</subject><subject>Turkey</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kD1PwzAQhi0EoqXwA1hQxG44n53aHhhQ1VKkSiABs-UmDk3VxMVukPrvcRU-JqYb7v24ewi5ZHDDAORtZAiMUWBAlRKS4hEZsjzXFCTCMRkCG3MqtBIDchbjGoBJ1PyUDBAUVxphSO5eXOia7NkGu1vtg6_LbO5D41uXLdyn28SsbrPJKvi2LrJpW7omzdmm88HHOp6Tk8puorv4niPyNpu-TuZ08fTwOLlf0IJL2FG0hUa0ubIAOXKJHEtZFaVYYlVy5rB0OXDJdCGE5mNZQsFyJS0gLkWuOB-R6z53G_xH5-LOrH0X2lRp0htS67E4iFgvKtJtMbjKbEPd2LA3DMyBl-l5mcTLHHgZTJ6r7-Bu2bjy1_EDKAmwF8S0at9d-Gv-P_ULxO5zUA</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Koroglu, Banu Kale</creator><creator>Ersoy, Ismail Hakki</creator><creator>Koroglu, Mert</creator><creator>Balkarli, Ayşe</creator><creator>Ersoy, Siddika</creator><creator>Varol, Simge</creator><creator>Tamer, Mehmet Numan</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20111001</creationdate><title>Serum Parathyroid Hormone Levels in Chronic Endemic Fluorosis</title><author>Koroglu, Banu Kale ; Ersoy, Ismail Hakki ; Koroglu, Mert ; Balkarli, Ayşe ; Ersoy, Siddika ; Varol, Simge ; Tamer, Mehmet Numan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-2ac922a58a005237232d7fcd4b2fd31e2de503719c449367d0c1587a022b45833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Endocrine system</topic><topic>Female</topic><topic>Fluoride Poisoning - blood</topic><topic>Fluorides</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Parathyroid Hormone - blood</topic><topic>Public health</topic><topic>Trace elements</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koroglu, Banu Kale</creatorcontrib><creatorcontrib>Ersoy, Ismail Hakki</creatorcontrib><creatorcontrib>Koroglu, Mert</creatorcontrib><creatorcontrib>Balkarli, Ayşe</creatorcontrib><creatorcontrib>Ersoy, Siddika</creatorcontrib><creatorcontrib>Varol, Simge</creatorcontrib><creatorcontrib>Tamer, Mehmet Numan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koroglu, Banu Kale</au><au>Ersoy, Ismail Hakki</au><au>Koroglu, Mert</au><au>Balkarli, Ayşe</au><au>Ersoy, Siddika</au><au>Varol, Simge</au><au>Tamer, Mehmet Numan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Parathyroid Hormone Levels in Chronic Endemic Fluorosis</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>143</volume><issue>1</issue><spage>79</spage><epage>86</epage><pages>79-86</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of excess parathyroid hormone (PTH) and fluorosis on bone. So fluoride might show its effect via PTH. We aimed to determine PTH levels in patients with endemic fluorosis to estimate the possible toxic effects of chronic fluoride intake. Fifty-six patients with endemic fluorosis and 28 age-, sex-, and body-mass-index-matched healthy controls were included in this study. Endemic fluorosis was diagnosed according to the clinical diagnosis criteria of Wang. The urine fluoride levels of fluorosis patients were significantly higher than those of control subjects as expected (1.9 ± 0.1 vs. 0.4 ± 0.1 mg/L, respectively;
P
< 0.001). PTH levels in fluorosis group were significantly higher than control group (65.09 ± 32.91 versus 47.40 ± 20.37, respectively;
P
= 0.01). The results of our study demonstrate that serum PTH levels are increased in patients with endemic fluorosis. Fluoride, by interfering calcium balance, may be the cause of secondary hyperparathyroidism.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>20838920</pmid><doi>10.1007/s12011-010-8847-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Biochemistry Biomedical and Life Sciences Biotechnology Endocrine system Female Fluoride Poisoning - blood Fluorides Homeostasis Humans Life Sciences Male Nutrition Oncology Parathyroid Hormone - blood Public health Trace elements Turkey |
| title | Serum Parathyroid Hormone Levels in Chronic Endemic Fluorosis |
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