Plummeting lenses in the TB clinic
In B6-independent forms, recycling to methionine is attenuated.1 Homocystinuria has often been found in people of European origin,2 and mutations in the CBS gene have been found in Brazilians of African descent.3 We have found only one previous report of homocystinuria from Africa; also compatible w...
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| Veröffentlicht in: | The Lancet (British edition) 2002-07, Vol.360 (9327), p.138-138 |
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| creator | Burton, MJ Burton, KJ Chuka-Okosa, CM Bailey, RL |
| description | In B6-independent forms, recycling to methionine is attenuated.1 Homocystinuria has often been found in people of European origin,2 and mutations in the CBS gene have been found in Brazilians of African descent.3 We have found only one previous report of homocystinuria from Africa; also compatible with autosomal recessive. inheritance.4 Isoniazid inhibits phosphorylation of pyridoxine,5 and pyridoxine is included in some tuberculosis treatment regimens to reduce the risk of isoniazid-induced neuropathy. The dramatic progression of ocular changes in our patient was probably precipitated by a rise in homocysteine levels caused by isoniazid therapy. Excess homocysteine is thought to react with cysteine residues, thereby disrupting the structure and function of fibrillin-1, the main component of the lens zonules (suspensory ligaments), leading to subluxation of the lens. |
| doi_str_mv | 10.1016/S0140-6736(02)09415-1 |
| format | Article |
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The dramatic progression of ocular changes in our patient was probably precipitated by a rise in homocysteine levels caused by isoniazid therapy. Excess homocysteine is thought to react with cysteine residues, thereby disrupting the structure and function of fibrillin-1, the main component of the lens zonules (suspensory ligaments), leading to subluxation of the lens.</description><identifier>ISSN: 0140-6736</identifier><identifier>ISSN: 0099-5355</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(02)09415-1</identifier><identifier>PMID: 12126825</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Antitubercular Agents - adverse effects ; Autosomal recessive inheritance ; Biological and medical sciences ; Bird, Sue ; Case reports ; Case studies ; Child ; Developing countries ; Disruption ; Drug toxicity and drugs side effects treatment ; Folic Acid - therapeutic use ; Habitus ; Homocysteine ; Homocystinuria - complications ; Homocystinuria - diagnosis ; Homocystinuria - drug therapy ; Humans ; Isoniazid - adverse effects ; LDCs ; Lens Subluxation - etiology ; Ligaments ; Male ; Medical diagnosis ; Medical sciences ; Metabolic disorders ; Methionine ; Mutation ; Ophthalmology ; Pharmacology. Drug treatments ; Phosphorylation ; Prophylaxis ; Pyridoxine ; Pyridoxine - therapeutic use ; Risk reduction ; Toxicity: eye ; Tuberculosis ; Tuberculosis, Pulmonary - complications ; Tuberculosis, Pulmonary - drug therapy</subject><ispartof>The Lancet (British edition), 2002-07, Vol.360 (9327), p.138-138</ispartof><rights>2002 Elsevier Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jul 13, 2002</rights><rights>Copyright Lancet Ltd. Jul 13, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-9104c62ae79ca9c5416ab430664f96ebaf6301a90539adaccfa2980f6bd927903</citedby><cites>FETCH-LOGICAL-c476t-9104c62ae79ca9c5416ab430664f96ebaf6301a90539adaccfa2980f6bd927903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2067753015?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13767540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12126825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burton, MJ</creatorcontrib><creatorcontrib>Burton, KJ</creatorcontrib><creatorcontrib>Chuka-Okosa, CM</creatorcontrib><creatorcontrib>Bailey, RL</creatorcontrib><title>Plummeting lenses in the TB clinic</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>In B6-independent forms, recycling to methionine is attenuated.1 Homocystinuria has often been found in people of European origin,2 and mutations in the CBS gene have been found in Brazilians of African descent.3 We have found only one previous report of homocystinuria from Africa; also compatible with autosomal recessive. inheritance.4 Isoniazid inhibits phosphorylation of pyridoxine,5 and pyridoxine is included in some tuberculosis treatment regimens to reduce the risk of isoniazid-induced neuropathy. The dramatic progression of ocular changes in our patient was probably precipitated by a rise in homocysteine levels caused by isoniazid therapy. Excess homocysteine is thought to react with cysteine residues, thereby disrupting the structure and function of fibrillin-1, the main component of the lens zonules (suspensory ligaments), leading to subluxation of the lens.</description><subject>Antitubercular Agents - adverse effects</subject><subject>Autosomal recessive inheritance</subject><subject>Biological and medical sciences</subject><subject>Bird, Sue</subject><subject>Case reports</subject><subject>Case studies</subject><subject>Child</subject><subject>Developing countries</subject><subject>Disruption</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Folic Acid - therapeutic use</subject><subject>Habitus</subject><subject>Homocysteine</subject><subject>Homocystinuria - complications</subject><subject>Homocystinuria - diagnosis</subject><subject>Homocystinuria - drug therapy</subject><subject>Humans</subject><subject>Isoniazid - adverse effects</subject><subject>LDCs</subject><subject>Lens Subluxation - etiology</subject><subject>Ligaments</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Metabolic disorders</subject><subject>Methionine</subject><subject>Mutation</subject><subject>Ophthalmology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphorylation</subject><subject>Prophylaxis</subject><subject>Pyridoxine</subject><subject>Pyridoxine - therapeutic use</subject><subject>Risk reduction</subject><subject>Toxicity: eye</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - complications</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><issn>0140-6736</issn><issn>0099-5355</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0F1LHDEUBuBQKnWr_QnKtEWpF2PPyeRjc1VaUSsIClroXchmztjIfGgyI_jvzbqLQqH0KjfPeXnzMraDcIiA6usVoIBS6Up9AX4ARqAs8Q2bodCilEL_fstmL2STvU_pFgCEAvmObSJHruZcztiny3bqOhpDf1O01CdKReiL8Q8V1z8K34Y--G220bg20Yf1u8V-nRxfH_0szy9Oz46-n5deaDWWBkF4xR1p453xUqByC1GBUqIxihauURWgMyAr42rnfeO4mUOjFrXh2kC1xfZXuXdxuJ8ojbYLyVPbup6GKVmc5_I5I8OPf8HbYYp97mbnBlEYzrP5_C_DQWktcxeZlVwpH4eUIjX2LobOxUeLYJcz2-eZ7XJDC9w-z2wx3-2u06dFR_Xr1XrXDPbWwCXv2ia63of06iqttBTLr3xbOcrDPgSKNvlAvac6RPKjrYfwnypPtZ-VRQ</recordid><startdate>20020713</startdate><enddate>20020713</enddate><creator>Burton, MJ</creator><creator>Burton, KJ</creator><creator>Chuka-Okosa, CM</creator><creator>Bailey, RL</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20020713</creationdate><title>Plummeting lenses in the TB clinic</title><author>Burton, MJ ; Burton, KJ ; Chuka-Okosa, CM ; Bailey, RL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-9104c62ae79ca9c5416ab430664f96ebaf6301a90539adaccfa2980f6bd927903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antitubercular Agents - adverse effects</topic><topic>Autosomal recessive inheritance</topic><topic>Biological and medical sciences</topic><topic>Bird, Sue</topic><topic>Case reports</topic><topic>Case studies</topic><topic>Child</topic><topic>Developing countries</topic><topic>Disruption</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Folic Acid - therapeutic use</topic><topic>Habitus</topic><topic>Homocysteine</topic><topic>Homocystinuria - complications</topic><topic>Homocystinuria - diagnosis</topic><topic>Homocystinuria - drug therapy</topic><topic>Humans</topic><topic>Isoniazid - adverse effects</topic><topic>LDCs</topic><topic>Lens Subluxation - etiology</topic><topic>Ligaments</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Metabolic disorders</topic><topic>Methionine</topic><topic>Mutation</topic><topic>Ophthalmology</topic><topic>Pharmacology. 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The dramatic progression of ocular changes in our patient was probably precipitated by a rise in homocysteine levels caused by isoniazid therapy. Excess homocysteine is thought to react with cysteine residues, thereby disrupting the structure and function of fibrillin-1, the main component of the lens zonules (suspensory ligaments), leading to subluxation of the lens.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>12126825</pmid><doi>10.1016/S0140-6736(02)09415-1</doi><tpages>1</tpages></addata></record> |
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| subjects | Antitubercular Agents - adverse effects Autosomal recessive inheritance Biological and medical sciences Bird, Sue Case reports Case studies Child Developing countries Disruption Drug toxicity and drugs side effects treatment Folic Acid - therapeutic use Habitus Homocysteine Homocystinuria - complications Homocystinuria - diagnosis Homocystinuria - drug therapy Humans Isoniazid - adverse effects LDCs Lens Subluxation - etiology Ligaments Male Medical diagnosis Medical sciences Metabolic disorders Methionine Mutation Ophthalmology Pharmacology. Drug treatments Phosphorylation Prophylaxis Pyridoxine Pyridoxine - therapeutic use Risk reduction Toxicity: eye Tuberculosis Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - drug therapy |
| title | Plummeting lenses in the TB clinic |
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