Methotrexate dose delivery is more important than ciclosporin level in graft-versus-host disease prophylaxis following T-replete reduced-intensity sibling allogeneic stem cell transplant

We investigated the contributions of methotrexate (MTX) and ciclosporin (CsA) prophylaxis to acute/chronic graft-versus-host disease (a/cGvHD) prevention following reduced-intensity conditioned allogeneic haematopoietic stem cell transplant (HSCT). Ninety-two fludarabine–melphalan sibling allo-SCT r...

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Veröffentlicht in:	International journal of hematology 2011-09, Vol.94 (3), p.266-278
Hauptverfasser:	Medd, Patrick, Monk, Ian, Danby, Robert, Malladi, Ram, Clifford, Ruth, Ellis, Amanda, Roberts, David, Hatton, Chris, Vyas, Paresh, Littlewood, Tim, Peniket, Andy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Cause of Death Cyclosporine - administration & dosage Female Graft vs Host Disease - epidemiology Graft vs Host Disease - etiology Graft vs Host Disease - prevention & control Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality Humans Immunosuppressive Agents - administration & dosage Kaplan-Meier Estimate Male Medical sciences Medicine Medicine & Public Health Methotrexate - administration & dosage Middle Aged Oncology Original Article Recurrence Siblings Transplantation Conditioning - adverse effects Transplantation, Homologous Young Adult
Online-Zugang:	Volltext
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