Targeted, Activatable, In Vivo Fluorescence Imaging of Prostate-Specific Membrane Antigen (PSMA) Positive Tumors Using the Quenched Humanized J591 Antibody–Indocyanine Green (ICG) Conjugate

In patients with prostate cancer, a positive surgical margin is associated with an increased risk of cancer recurrence and poorer outcome, yet margin status cannot be determined during the surgery. An in vivo optical imaging probe that could identify the tumor margins during surgery could result in...

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Veröffentlicht in:	Bioconjugate chemistry 2011-08, Vol.22 (8), p.1700-1705
Hauptverfasser:	Nakajima, Takahito, Mitsunaga, Makoto, Bander, Neil H, Heston, Warren D, Choyke, Peter L, Kobayashi, Hisataka
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Binding sites Biochemistry Diagnostic Imaging - methods Fluorescence Fluorescent Dyes Health risks Humans Immunoconjugates Indocyanine Green Lymph nodes Lymphatic system Male Molecular Probes Monoclonal antibodies Prostate cancer Prostate-Specific Antigen - analysis Prostate-Specific Antigen - immunology Prostatic Neoplasms - diagnosis Protein Binding Tumors
Online-Zugang:	Volltext
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