Different effects of low- and high-dose insulin on ROS production and VEGF expression in bovine retinal microvascular endothelial cells in the presence of high glucose

Background Clinical trials have demonstrated that acute intensive insulin therapy may cause transient worsening of retinopathy in type 1 and type 2 diabetes patients. However, the related mechanism still remains controversial. The purpose of the present study was to investigate the effect of insulin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2011-09, Vol.249 (9), p.1303-1310
Hauptverfasser:	Wu, Haixiang, Jiang, Chunhui, Gan, Dekang, Liao, Yujie, Ren, Hui, Sun, Zhongcui, Zhang, Meng, Xu, Gezhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Science Cattle Diabetic Retinopathy - drug therapy Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Dose-Response Relationship, Drug Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Glucose - pharmacology Hypoglycemic Agents - pharmacology Insulin - pharmacology Ion Channels - genetics Ion Channels - metabolism Medicine Medicine & Public Health Membrane Potential, Mitochondrial - drug effects Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Ophthalmology Primary Cell Culture Reactive Oxygen Species - metabolism Retinal Vessels - cytology RNA, Messenger - metabolism Uncoupling Protein 2 Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!