Midazolam premedication delays recovery from propofol-induced sevoflurane anesthesia in children 1-3 yr
To study the effect of midazolam premedication on the recovery characteristics of sevoflurane anesthesia induced with propofol in pediatric outpatients. Sixty children, one to three years, presenting for ambulatory adenoidectomy were randomly assigned , in a double-blind fashion, to receive either 0...
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| Veröffentlicht in: | Canadian journal of anesthesia 1999-08, Vol.46 (8), p.766-771 |
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| creator | VIITANEN, H ANNILA, P VIITANEN, M YLI-HANKALA, A |
| description | To study the effect of midazolam premedication on the recovery characteristics of sevoflurane anesthesia induced with propofol in pediatric outpatients.
Sixty children, one to three years, presenting for ambulatory adenoidectomy were randomly assigned , in a double-blind fashion, to receive either 0.5 mg x kg(-1) midazolam (Group M) or placebo (Group P) p.o. 30 min before anesthesia. Anesthesia was induced with 10 microg x kg(-1) atropine, 10 microg x kg(-1) alfentanil, and 3-4 mg x kg(-1) propofol i.v.. Tracheal intubation was facilitated with 0.2 mg x kg(-1) mivacurium. Anesthesia was maintained with nitrous oxide/oxygen (FiO2 0.3) and sevoflurane with controlled ventilation. Recovery characteristics were compared using the modified Aldrete scoring system, the Pain/Discomfort scale and measuring specific recovery end-points (emergence, full Aldrete score, discharge). A postoperative questionnaire was used to evaluate the children's well-being at home until 24 hr after discharge.
Emergence from anesthesia (22 +/- 9 vs 16 +/- 6 min (mean +/- SD), P = 0.005) and achieving full Aldrete scores (30 +/- 11 vs 24 +/- 16 min, P = 0.006) were delayed in patients receiving midazolam. Children in the placebo group were given postoperative analgesia sooner than those in the midazolam group (18 +/- 11 vs 23 +/- 8 min, P = 0.009). More children premedicated with midazolam suffered from arousal distress (20% vs 3%, P = 0.04) and scored higher on the Pain/Discomfort scale (P = 0.004) at 20 min after arrival in the recovery room. Discharge was not affected by premedication and well-being at home was similar in the groups.
Oral premedication with midazolam delays early recovery but not discharge after ambulatory sevoflurane anesthesia induced with propofol in children one to three years. Midazolam did not improve the quality of recovery. |
| doi_str_mv | 10.1007/BF03013912 |
| format | Article |
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Sixty children, one to three years, presenting for ambulatory adenoidectomy were randomly assigned , in a double-blind fashion, to receive either 0.5 mg x kg(-1) midazolam (Group M) or placebo (Group P) p.o. 30 min before anesthesia. Anesthesia was induced with 10 microg x kg(-1) atropine, 10 microg x kg(-1) alfentanil, and 3-4 mg x kg(-1) propofol i.v.. Tracheal intubation was facilitated with 0.2 mg x kg(-1) mivacurium. Anesthesia was maintained with nitrous oxide/oxygen (FiO2 0.3) and sevoflurane with controlled ventilation. Recovery characteristics were compared using the modified Aldrete scoring system, the Pain/Discomfort scale and measuring specific recovery end-points (emergence, full Aldrete score, discharge). A postoperative questionnaire was used to evaluate the children's well-being at home until 24 hr after discharge.
Emergence from anesthesia (22 +/- 9 vs 16 +/- 6 min (mean +/- SD), P = 0.005) and achieving full Aldrete scores (30 +/- 11 vs 24 +/- 16 min, P = 0.006) were delayed in patients receiving midazolam. Children in the placebo group were given postoperative analgesia sooner than those in the midazolam group (18 +/- 11 vs 23 +/- 8 min, P = 0.009). More children premedicated with midazolam suffered from arousal distress (20% vs 3%, P = 0.04) and scored higher on the Pain/Discomfort scale (P = 0.004) at 20 min after arrival in the recovery room. Discharge was not affected by premedication and well-being at home was similar in the groups.
Oral premedication with midazolam delays early recovery but not discharge after ambulatory sevoflurane anesthesia induced with propofol in children one to three years. Midazolam did not improve the quality of recovery.</description><identifier>ISSN: 0832-610X</identifier><identifier>EISSN: 1496-8975</identifier><identifier>DOI: 10.1007/BF03013912</identifier><identifier>PMID: 10451136</identifier><identifier>CODEN: CJOAEP</identifier><language>eng</language><publisher>Toronto, ON: Canadian Anesthesiologists' Society</publisher><subject>Adenoidectomy ; Adjuvants, Anesthesia - adverse effects ; Ambulatory Surgical Procedures ; Anesthesia Recovery Period ; Anesthesia, General ; Anesthetics, Inhalation ; Anesthetics, Intravenous ; Biological and medical sciences ; Child, Preschool ; Double-Blind Method ; Female ; Humans ; Hypnotics. Sedatives ; Infant ; Intubation ; Male ; Medical sciences ; Methyl Ethers ; Midazolam - adverse effects ; Neuropharmacology ; Pharmacology. Drug treatments ; Postoperative Complications - epidemiology ; Postoperative Complications - psychology ; Propofol ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Questionnaires ; Ventilation</subject><ispartof>Canadian journal of anesthesia, 1999-08, Vol.46 (8), p.766-771</ispartof><rights>1999 INIST-CNRS</rights><rights>Canadian Anesthesiologists 1999.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-10f44dd7fe4247193cc38aa478c5329ec1c780d96dfc5f176dc75e88dd1897313</citedby><cites>FETCH-LOGICAL-c375t-10f44dd7fe4247193cc38aa478c5329ec1c780d96dfc5f176dc75e88dd1897313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1899356$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10451136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VIITANEN, H</creatorcontrib><creatorcontrib>ANNILA, P</creatorcontrib><creatorcontrib>VIITANEN, M</creatorcontrib><creatorcontrib>YLI-HANKALA, A</creatorcontrib><title>Midazolam premedication delays recovery from propofol-induced sevoflurane anesthesia in children 1-3 yr</title><title>Canadian journal of anesthesia</title><addtitle>Can J Anaesth</addtitle><description>To study the effect of midazolam premedication on the recovery characteristics of sevoflurane anesthesia induced with propofol in pediatric outpatients.
Sixty children, one to three years, presenting for ambulatory adenoidectomy were randomly assigned , in a double-blind fashion, to receive either 0.5 mg x kg(-1) midazolam (Group M) or placebo (Group P) p.o. 30 min before anesthesia. Anesthesia was induced with 10 microg x kg(-1) atropine, 10 microg x kg(-1) alfentanil, and 3-4 mg x kg(-1) propofol i.v.. Tracheal intubation was facilitated with 0.2 mg x kg(-1) mivacurium. Anesthesia was maintained with nitrous oxide/oxygen (FiO2 0.3) and sevoflurane with controlled ventilation. Recovery characteristics were compared using the modified Aldrete scoring system, the Pain/Discomfort scale and measuring specific recovery end-points (emergence, full Aldrete score, discharge). A postoperative questionnaire was used to evaluate the children's well-being at home until 24 hr after discharge.
Emergence from anesthesia (22 +/- 9 vs 16 +/- 6 min (mean +/- SD), P = 0.005) and achieving full Aldrete scores (30 +/- 11 vs 24 +/- 16 min, P = 0.006) were delayed in patients receiving midazolam. Children in the placebo group were given postoperative analgesia sooner than those in the midazolam group (18 +/- 11 vs 23 +/- 8 min, P = 0.009). More children premedicated with midazolam suffered from arousal distress (20% vs 3%, P = 0.04) and scored higher on the Pain/Discomfort scale (P = 0.004) at 20 min after arrival in the recovery room. Discharge was not affected by premedication and well-being at home was similar in the groups.
Oral premedication with midazolam delays early recovery but not discharge after ambulatory sevoflurane anesthesia induced with propofol in children one to three years. Midazolam did not improve the quality of recovery.</description><subject>Adenoidectomy</subject><subject>Adjuvants, Anesthesia - adverse effects</subject><subject>Ambulatory Surgical Procedures</subject><subject>Anesthesia Recovery Period</subject><subject>Anesthesia, General</subject><subject>Anesthetics, Inhalation</subject><subject>Anesthetics, Intravenous</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics. Sedatives</subject><subject>Infant</subject><subject>Intubation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methyl Ethers</subject><subject>Midazolam - adverse effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - psychology</subject><subject>Propofol</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Questionnaires</subject><subject>Ventilation</subject><issn>0832-610X</issn><issn>1496-8975</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpNkE1LAzEQhoMotlYv_gAJ4klYzTSbTXLUYlWoeFHwtsR82JTtpibdwvrrTWlBD8NcHt5550HoHMgNEMJv76eEEqASxgdoCKWsCiE5O0RDIui4qIB8DNBJSgtCiKiYOEYDICUDoNUQfb14o35Co5Z4Fe3SGq_V2ocWG9uoPuFoddjY2GMXwxYJq-BCU_jWdNoanOwmuKaLqrU4T1rPbfIK-xbruW9MtC2GguI-nqIjp5pkz_Z7hN6nD2-Tp2L2-vg8uZsVmnK2LoC4sjSGO1uOSw6Sak2FUiUXmtGxtBo0F8TIyjjNHPDKaM6sEMZA_pkCHaHLXW6u-t3lQvUidLHNJ2shGKGcQJmh6x2kY0gpWlevol-q2NdA6q3S-k9phi_2id1n9vMP3TnMwNUeUEmrxmUZ2qc_TkhJWUV_AfTFffs</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>VIITANEN, H</creator><creator>ANNILA, P</creator><creator>VIITANEN, M</creator><creator>YLI-HANKALA, A</creator><general>Canadian Anesthesiologists' Society</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>19990801</creationdate><title>Midazolam premedication delays recovery from propofol-induced sevoflurane anesthesia in children 1-3 yr</title><author>VIITANEN, H ; ANNILA, P ; VIITANEN, M ; YLI-HANKALA, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-10f44dd7fe4247193cc38aa478c5329ec1c780d96dfc5f176dc75e88dd1897313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenoidectomy</topic><topic>Adjuvants, Anesthesia - adverse effects</topic><topic>Ambulatory Surgical Procedures</topic><topic>Anesthesia Recovery Period</topic><topic>Anesthesia, General</topic><topic>Anesthetics, Inhalation</topic><topic>Anesthetics, Intravenous</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics. Sedatives</topic><topic>Infant</topic><topic>Intubation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methyl Ethers</topic><topic>Midazolam - adverse effects</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - psychology</topic><topic>Propofol</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Questionnaires</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VIITANEN, H</creatorcontrib><creatorcontrib>ANNILA, P</creatorcontrib><creatorcontrib>VIITANEN, M</creatorcontrib><creatorcontrib>YLI-HANKALA, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Canadian journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VIITANEN, H</au><au>ANNILA, P</au><au>VIITANEN, M</au><au>YLI-HANKALA, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Midazolam premedication delays recovery from propofol-induced sevoflurane anesthesia in children 1-3 yr</atitle><jtitle>Canadian journal of anesthesia</jtitle><addtitle>Can J Anaesth</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>46</volume><issue>8</issue><spage>766</spage><epage>771</epage><pages>766-771</pages><issn>0832-610X</issn><eissn>1496-8975</eissn><coden>CJOAEP</coden><abstract>To study the effect of midazolam premedication on the recovery characteristics of sevoflurane anesthesia induced with propofol in pediatric outpatients.
Sixty children, one to three years, presenting for ambulatory adenoidectomy were randomly assigned , in a double-blind fashion, to receive either 0.5 mg x kg(-1) midazolam (Group M) or placebo (Group P) p.o. 30 min before anesthesia. Anesthesia was induced with 10 microg x kg(-1) atropine, 10 microg x kg(-1) alfentanil, and 3-4 mg x kg(-1) propofol i.v.. Tracheal intubation was facilitated with 0.2 mg x kg(-1) mivacurium. Anesthesia was maintained with nitrous oxide/oxygen (FiO2 0.3) and sevoflurane with controlled ventilation. Recovery characteristics were compared using the modified Aldrete scoring system, the Pain/Discomfort scale and measuring specific recovery end-points (emergence, full Aldrete score, discharge). A postoperative questionnaire was used to evaluate the children's well-being at home until 24 hr after discharge.
Emergence from anesthesia (22 +/- 9 vs 16 +/- 6 min (mean +/- SD), P = 0.005) and achieving full Aldrete scores (30 +/- 11 vs 24 +/- 16 min, P = 0.006) were delayed in patients receiving midazolam. Children in the placebo group were given postoperative analgesia sooner than those in the midazolam group (18 +/- 11 vs 23 +/- 8 min, P = 0.009). More children premedicated with midazolam suffered from arousal distress (20% vs 3%, P = 0.04) and scored higher on the Pain/Discomfort scale (P = 0.004) at 20 min after arrival in the recovery room. Discharge was not affected by premedication and well-being at home was similar in the groups.
Oral premedication with midazolam delays early recovery but not discharge after ambulatory sevoflurane anesthesia induced with propofol in children one to three years. Midazolam did not improve the quality of recovery.</abstract><cop>Toronto, ON</cop><pub>Canadian Anesthesiologists' Society</pub><pmid>10451136</pmid><doi>10.1007/BF03013912</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoidectomy Adjuvants, Anesthesia - adverse effects Ambulatory Surgical Procedures Anesthesia Recovery Period Anesthesia, General Anesthetics, Inhalation Anesthetics, Intravenous Biological and medical sciences Child, Preschool Double-Blind Method Female Humans Hypnotics. Sedatives Infant Intubation Male Medical sciences Methyl Ethers Midazolam - adverse effects Neuropharmacology Pharmacology. Drug treatments Postoperative Complications - epidemiology Postoperative Complications - psychology Propofol Psychology. Psychoanalysis. Psychiatry Psychopharmacology Questionnaires Ventilation |
| title | Midazolam premedication delays recovery from propofol-induced sevoflurane anesthesia in children 1-3 yr |
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