Early gastric cancer combined with multiple metachronous osteosclerotic bone and bone marrow metastases that responded to chemoradiotherapy
We report a 75-year-old woman who suffered multiple metachronous osteosclerotic bone metastases 4 years after a distal gastrectomy for early gastric cancer (EGC). The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis...
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| Veröffentlicht in: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2011-08, Vol.14 (3), p.295-299 |
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| container_title | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association |
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| creator | Saito, Masaaki Kiyozaki, Hirokazu Chiba, Fumihiro Takata, Osamu Yoshida, Takayoshi Shuto, Chio Yamada, Shigeki Konishi, Fumio |
| description | We report a 75-year-old woman who suffered multiple metachronous osteosclerotic bone metastases 4 years after a distal gastrectomy for early gastric cancer (EGC). The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis was noted. To the best of our knowledge, cases of EGC combined with metachronous osteosclerotic multiple bone and bone marrow metastases that respond to chemoradiotherapy are very rare. In this case, the multiple bone metastases were diagnosed 4 years after surgery. The patient’s metastatic tumor was successfully treated using S-1, paclitaxel, and camptothecin, with subsequent irradiation. The patient survived for 24 months after the treatment, without having any major symptoms. |
| doi_str_mv | 10.1007/s10120-011-0062-0 |
| format | Article |
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The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis was noted. To the best of our knowledge, cases of EGC combined with metachronous osteosclerotic multiple bone and bone marrow metastases that respond to chemoradiotherapy are very rare. In this case, the multiple bone metastases were diagnosed 4 years after surgery. The patient’s metastatic tumor was successfully treated using S-1, paclitaxel, and camptothecin, with subsequent irradiation. 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The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis was noted. To the best of our knowledge, cases of EGC combined with metachronous osteosclerotic multiple bone and bone marrow metastases that respond to chemoradiotherapy are very rare. In this case, the multiple bone metastases were diagnosed 4 years after surgery. The patient’s metastatic tumor was successfully treated using S-1, paclitaxel, and camptothecin, with subsequent irradiation. The patient survived for 24 months after the treatment, without having any major symptoms.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bone Marrow Neoplasms - secondary</subject><subject>Bone Marrow Neoplasms - therapy</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Neoplasms - therapy</subject><subject>Camptothecin - administration & dosage</subject><subject>Cancer Research</subject><subject>Case Report</subject><subject>Chemoradiotherapy</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Oxonic Acid - administration & dosage</subject><subject>Paclitaxel - administration & dosage</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - therapy</subject><subject>Surgical Oncology</subject><subject>Tegafur - administration & dosage</subject><subject>Treatment Outcome</subject><issn>1436-3291</issn><issn>1436-3305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtKxTAQhoMo3h_AjQT31Zm0J2mXIt5AcKPrkKZTW2mbmqTIeQZf2h7rZSUMzMD8_z_Mx9gJwjkCqIuAgAISQEwApEhgi-1jlsokTWG1_TOLAvfYQQivALgqUO6yPYFSIWRqn31cG9-t-YsJ0beWWzNY8ty6vmwHqvh7GxveT11sx454T9HYxrvBTYG7EMkF25F3cXaWbiBuhmoZeuO9e_8yhLko8NiYyD2F0Q3VHBwdtw31zpuqdbEhb8b1EdupTRfo-Lsfsueb66eru-Th8fb-6vIhsVmqYkJQYo4iI5Spqi0W0pSqELJWpYCyMraqy7qGQslVlosMilzVROlKiUxaqiA9ZGdL7ujd20Qh6lc3-WE-qfM8k3mO6UaEi8h6F4KnWo--nd9aawS9oa8X-nqmrzf09cZz-h08lT1Vv44f3LNALIIwr4YX8n-X_0_9BDWDkxI</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Saito, Masaaki</creator><creator>Kiyozaki, Hirokazu</creator><creator>Chiba, Fumihiro</creator><creator>Takata, Osamu</creator><creator>Yoshida, Takayoshi</creator><creator>Shuto, Chio</creator><creator>Yamada, Shigeki</creator><creator>Konishi, Fumio</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20110801</creationdate><title>Early gastric cancer combined with multiple metachronous osteosclerotic bone and bone marrow metastases that responded to chemoradiotherapy</title><author>Saito, Masaaki ; 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| ispartof | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2011-08, Vol.14 (3), p.295-299 |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Abdominal Surgery Adenocarcinoma - pathology Adenocarcinoma - therapy Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone Marrow Neoplasms - secondary Bone Marrow Neoplasms - therapy Bone Neoplasms - secondary Bone Neoplasms - therapy Camptothecin - administration & dosage Cancer Research Case Report Chemoradiotherapy Drug Combinations Female Gastric cancer Gastroenterology Humans Lymphatic Metastasis Medicine Medicine & Public Health Oncology Oxonic Acid - administration & dosage Paclitaxel - administration & dosage Stomach Neoplasms - pathology Stomach Neoplasms - therapy Surgical Oncology Tegafur - administration & dosage Treatment Outcome |
| title | Early gastric cancer combined with multiple metachronous osteosclerotic bone and bone marrow metastases that responded to chemoradiotherapy |
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