Global visualization and alignments of whole bacterial genomes
We present a novel visualization technique to align whole bacterial genomes with millions of nucleotides. Our basic design combines the descriptive power of pixel-based visualizations with the interpretative strength of digital image-processing filters. The innovative use of pixel enhancement techni...
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| Veröffentlicht in: | IEEE Transactions on Visualization and Computer Graphics 2003-07, Vol.9 (3), p.361-377 |
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| container_end_page | 377 |
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| container_title | IEEE Transactions on Visualization and Computer Graphics |
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| creator | Pak Chung Wong Kwong Kwok Wong Foote, H. Thomas, J. |
| description | We present a novel visualization technique to align whole bacterial genomes with millions of nucleotides. Our basic design combines the descriptive power of pixel-based visualizations with the interpretative strength of digital image-processing filters. The innovative use of pixel enhancement techniques on pixel-based visualizations brings out the best of the recursive data patterns and further enhances the effectiveness of the visualization techniques. The result is a fast, versatile, and cost-effective analysis tool to reveal hidden structures that might lead to the discovery of functional identifications as well as phenotypic changes of whole bacterial genomes. Nine different whole bacterial genomes obtained from public genome banks are used to demonstrate our designs and prove their viability. Although the design of the new visualization technique is targeted at analyzing genomic sequences, we show with examples that it can be used to study other types of sequential data sets with a priori orders. |
| doi_str_mv | 10.1109/TVCG.2003.1207444 |
| format | Article |
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| subjects | BACTERIA BASIC BIOLOGICAL SCIENCES BIOINFORMATICS Capacitive sensors COMPUTER GRAPHICS CONSTRAST STRETCHING, VISUAL ANALYTICS, VA Data visualization Digital images DNA ENVIRONMENTAL MOLECULAR SCIENCES LABORATORY, VISUALIZATION GAUSSIAN SMOOTHING GENETIC MAPPING Genomics HILBERT CURVE HISTOGRAM EQUATION Humans IMAGE PROCESSING Information analysis Microorganisms NUCLEOTIDES Sequences WHOLE GENOME ALIGNMENT |
| title | Global visualization and alignments of whole bacterial genomes |
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