SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses

Neurotransmission depends on the exo-endocytosis of synaptic vesicles at active zones. Synaptobrevin 2 [also known as vesicle-associated membrane protein 2 (VAMP2)], the most abundant synaptic vesicle protein and a major soluble NSF attachment protein receptor (SNARE) component, is required for fast...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-08, Vol.108 (33), p.13540-13545
Hauptverfasser:	Koo, Seong Joo, Markovic, Stefan, Puchkov, Dmytro, Mahrenholz, Carsten C., Beceren-Braun, Figen, Maritzen, Tanja, Dernedde, Jens, Volkmer, Rudolf, Oschkinat, Hartmut, Haucke, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - physiology Animals Application programming interfaces binding sites Biological Sciences Cell Line clathrin Endocytosis exocytosis Hippocampus - cytology Hippocampus - metabolism Humans Leukemia Mice Monomeric Clathrin Assembly Proteins - physiology Mutagenesis Neurological disorders Neurons NMR Nuclear magnetic resonance nuclear magnetic resonance spectroscopy Physiological regulation Protein Binding Protein Transport protein-protein interactions Proteins R-SNARE Proteins - metabolism R-SNARE Proteins - physiology Rats Recycling Serenity site-directed mutagenesis Small interfering RNA SNARE Proteins synapse Synapses Synapses - metabolism Synaptic Transmission
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