Urinary excretion of tubular proteins and the technetium-99m dimercaptosuccinic acid (DMSA) absolute renal uptake in partial ureteral obstruction in rats: a functional evaluation of hydronephrotic kidneys
The aim of this longitudinal study was to evaluate tubular proteinuria in rats with unilateral (UPO) and bilateral (BPO) partial ureteral obstruction with the dimercaptosuccinic acid (DMSA) scan as the gold standard for measuring renal tubular damage. We studied 70 female Wistar rats: 28 animals wit...
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| Veröffentlicht in: | Urolithiasis 1999-04, Vol.27 (2), p.127-133 |
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| creator | Everaert, K Van de Wiele, C Delanghe, J Vander Eecken, H Van Haelst, J P Van de Voorde, J Dierckx, R A Oosterlinck, W |
| description | The aim of this longitudinal study was to evaluate tubular proteinuria in rats with unilateral (UPO) and bilateral (BPO) partial ureteral obstruction with the dimercaptosuccinic acid (DMSA) scan as the gold standard for measuring renal tubular damage. We studied 70 female Wistar rats: 28 animals with UPO, 28 animals with BPO, 7 sham-operated animals, and 7 controls. All animals with obstructed ureters showed renal dilatation on the diethylenetriaminepentaacetic acid DTPA images 1 and 5 weeks postoperatively. One week following UPO and BPO, tubular proteinuria and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity increased (P < 0.01) and the absolute DMSA uptake decreased (P < 0.01). Persistently (week 6) high tubular proteinuria was found in 29% of the animals and was related to severe damage on the DMSA scan (P < 0.01) and to albuminuria (P < 0.05). Renal tubular damage was demonstrated by measuring renal enzymes, tubular proteins, and DMSA uptake after UPO and BPO. Persistent elevated tubular proteinuria was related to severely damaged kidneys. |
| doi_str_mv | 10.1007/s002400050098 |
| format | Article |
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Persistent elevated tubular proteinuria was related to severely damaged kidneys.</description><subject>Acetylglucosaminidase - urine</subject><subject>Animals</subject><subject>Female</subject><subject>Hydronephrosis - diagnostic imaging</subject><subject>Hydronephrosis - metabolism</subject><subject>Kidneys</subject><subject>Proteins - analysis</subject><subject>Proteinuria - metabolism</subject><subject>Proteinuria - urine</subject><subject>Radionuclide Imaging</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Technetium Tc 99m Dimercaptosuccinic Acid - metabolism</subject><subject>Technetium Tc 99m Pentetate - analogs & derivatives</subject><subject>Technetium Tc 99m Pentetate - metabolism</subject><subject>Time Factors</subject><subject>Ureteral Obstruction - diagnostic imaging</subject><subject>Ureteral Obstruction - metabolism</subject><subject>Ureteral Obstruction - urine</subject><issn>0300-5623</issn><issn>2194-7228</issn><issn>1434-0879</issn><issn>2194-7236</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1v1DAQhi0EotvCkSuyOCA4BMaJN457q0r5kIo4UM6RY4-1bhM7-AOx_5EfhdstEnCyNX4073geQp4xeMMAxNsE0HIA2ALI4QHZMN7xBgYhH5INdADNtm-7I3Kc0jUAE71sH5MjBrzlneQb8utbdF7FPcWfOmJ2wdNgaS5TmVWkawwZnU9UeUPzDmlGvfMVK0sj5UKNWzBqteaQitbOO02Vdoa-evf569lrqqYU5pKRRvRqpmXN6gap83RVMbvbSo3EWC9hSjkWfZdf36PK6ZQqaou_q1UCf6i5qD8D7vYmBo_rrg5YQ2-c8bhPT8gjq-aET-_PE3L1_uLq_GNz-eXDp_Ozy0Z3rM-NNJxZs5WTQrnFXiMOQoFVnagL45ZbnGzPTAsccNvZXhspsJ2YQOyUbbsT8vLQtq7ne8GUx8UljfOsPIaSxl5KNggmK_jiP_A6lFh_k8Zh4NWUEH2FmgOkY0gpoh3X6JaqZGQw3ioe_1Fc-ef3Tcu0oPmLPjjtfgPs06bu</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Everaert, K</creator><creator>Van de Wiele, C</creator><creator>Delanghe, J</creator><creator>Vander Eecken, H</creator><creator>Van Haelst, J P</creator><creator>Van de Voorde, J</creator><creator>Dierckx, R A</creator><creator>Oosterlinck, W</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Urinary excretion of tubular proteins and the technetium-99m dimercaptosuccinic acid (DMSA) absolute renal uptake in partial ureteral obstruction in rats: a functional evaluation of hydronephrotic kidneys</title><author>Everaert, K ; Van de Wiele, C ; Delanghe, J ; Vander Eecken, H ; Van Haelst, J P ; Van de Voorde, J ; Dierckx, R A ; Oosterlinck, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-9d41fd59bae95e6cee87a0fa370304f4febf61d2040e53f6cd97e2b17ee3af23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetylglucosaminidase - urine</topic><topic>Animals</topic><topic>Female</topic><topic>Hydronephrosis - diagnostic imaging</topic><topic>Hydronephrosis - metabolism</topic><topic>Kidneys</topic><topic>Proteins - analysis</topic><topic>Proteinuria - metabolism</topic><topic>Proteinuria - urine</topic><topic>Radionuclide Imaging</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Technetium Tc 99m Dimercaptosuccinic Acid - metabolism</topic><topic>Technetium Tc 99m Pentetate - analogs & derivatives</topic><topic>Technetium Tc 99m Pentetate - metabolism</topic><topic>Time Factors</topic><topic>Ureteral Obstruction - diagnostic imaging</topic><topic>Ureteral Obstruction - metabolism</topic><topic>Ureteral Obstruction - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Everaert, K</creatorcontrib><creatorcontrib>Van de Wiele, C</creatorcontrib><creatorcontrib>Delanghe, J</creatorcontrib><creatorcontrib>Vander Eecken, H</creatorcontrib><creatorcontrib>Van Haelst, J P</creatorcontrib><creatorcontrib>Van de Voorde, J</creatorcontrib><creatorcontrib>Dierckx, R A</creatorcontrib><creatorcontrib>Oosterlinck, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Urolithiasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Everaert, K</au><au>Van de Wiele, C</au><au>Delanghe, J</au><au>Vander Eecken, H</au><au>Van Haelst, J P</au><au>Van de Voorde, J</au><au>Dierckx, R A</au><au>Oosterlinck, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary excretion of tubular proteins and the technetium-99m dimercaptosuccinic acid (DMSA) absolute renal uptake in partial ureteral obstruction in rats: a functional evaluation of hydronephrotic kidneys</atitle><jtitle>Urolithiasis</jtitle><addtitle>Urol Res</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>27</volume><issue>2</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0300-5623</issn><issn>2194-7228</issn><eissn>1434-0879</eissn><eissn>2194-7236</eissn><abstract>The aim of this longitudinal study was to evaluate tubular proteinuria in rats with unilateral (UPO) and bilateral (BPO) partial ureteral obstruction with the dimercaptosuccinic acid (DMSA) scan as the gold standard for measuring renal tubular damage. We studied 70 female Wistar rats: 28 animals with UPO, 28 animals with BPO, 7 sham-operated animals, and 7 controls. All animals with obstructed ureters showed renal dilatation on the diethylenetriaminepentaacetic acid DTPA images 1 and 5 weeks postoperatively. One week following UPO and BPO, tubular proteinuria and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity increased (P < 0.01) and the absolute DMSA uptake decreased (P < 0.01). Persistently (week 6) high tubular proteinuria was found in 29% of the animals and was related to severe damage on the DMSA scan (P < 0.01) and to albuminuria (P < 0.05). Renal tubular damage was demonstrated by measuring renal enzymes, tubular proteins, and DMSA uptake after UPO and BPO. Persistent elevated tubular proteinuria was related to severely damaged kidneys.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>10424394</pmid><doi>10.1007/s002400050098</doi><tpages>7</tpages></addata></record> |
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| ispartof | Urolithiasis, 1999-04, Vol.27 (2), p.127-133 |
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| subjects | Acetylglucosaminidase - urine Animals Female Hydronephrosis - diagnostic imaging Hydronephrosis - metabolism Kidneys Proteins - analysis Proteinuria - metabolism Proteinuria - urine Radionuclide Imaging Rats Rats, Wistar Rodents Technetium Tc 99m Dimercaptosuccinic Acid - metabolism Technetium Tc 99m Pentetate - analogs & derivatives Technetium Tc 99m Pentetate - metabolism Time Factors Ureteral Obstruction - diagnostic imaging Ureteral Obstruction - metabolism Ureteral Obstruction - urine |
| title | Urinary excretion of tubular proteins and the technetium-99m dimercaptosuccinic acid (DMSA) absolute renal uptake in partial ureteral obstruction in rats: a functional evaluation of hydronephrotic kidneys |
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