GC–MS Quantitation and Identification of Bisphenol-A Isolated from Water
Isolation and identification of organic compounds is a necessary skill chemistry students must be able to do with proficiency. In this upper-level undergraduate laboratory, students isolate bisphenol-A (BPA; 4-4′-isopropylidenediphenol) from water using solid-phase extraction (SPE) followed by deriv...
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| Veröffentlicht in: | Journal of chemical education 2011-08, Vol.88 (8), p.1130-1132 |
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| container_title | Journal of chemical education |
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| creator | Mead, Ralph N Seaton, Pamela J |
| description | Isolation and identification of organic compounds is a necessary skill chemistry students must be able to do with proficiency. In this upper-level undergraduate laboratory, students isolate bisphenol-A (BPA; 4-4′-isopropylidenediphenol) from water using solid-phase extraction (SPE) followed by derivatization with analysis by GC–MS. The students learn the proper steps and techniques of SPE that include conditioning, equilibration, washing, and eluting. The students are then asked to identify the BPA peak from the GC–MS analysis of a mixture of standards based upon the molecular ion, keeping in mind the change in molecular weight upon derivatization. Interpretation of GC–MS data showed predictable fragmentation and highlights the formation of benzylic carbocations. Quantification was done by an external calibration curve and the sample was quantified and a percent recovery is calculated. |
| doi_str_mv | 10.1021/ed1006053 |
| format | Article |
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In this upper-level undergraduate laboratory, students isolate bisphenol-A (BPA; 4-4′-isopropylidenediphenol) from water using solid-phase extraction (SPE) followed by derivatization with analysis by GC–MS. The students learn the proper steps and techniques of SPE that include conditioning, equilibration, washing, and eluting. The students are then asked to identify the BPA peak from the GC–MS analysis of a mixture of standards based upon the molecular ion, keeping in mind the change in molecular weight upon derivatization. Interpretation of GC–MS data showed predictable fragmentation and highlights the formation of benzylic carbocations. Quantification was done by an external calibration curve and the sample was quantified and a percent recovery is calculated.</description><identifier>ISSN: 0021-9584</identifier><identifier>EISSN: 1938-1328</identifier><identifier>DOI: 10.1021/ed1006053</identifier><identifier>CODEN: JCEDA8</identifier><language>eng</language><publisher>Easton: American Chemical Society and Division of Chemical Education, Inc</publisher><subject>Bisphenol A ; Chemical compounds ; College Science ; College students ; Conditioning ; Extraction processes ; Identification ; Ions ; Molecular ions ; Molecular Structure ; Molecular weight ; Organic Chemistry ; Organic compounds ; Science Instruction ; Science Laboratories ; Science Process Skills ; Scientific Principles ; Solid phases ; Students ; Undergraduate Study ; Water</subject><ispartof>Journal of chemical education, 2011-08, Vol.88 (8), p.1130-1132</ispartof><rights>Copyright © 2011 American Chemical Society and Division of Chemical Education, Inc.</rights><rights>Copyright American Chemical Society Aug 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a307t-744e47d48d55ee93226803c80fd1bb0b601d7a352b5a87058219bc9a2928978f3</citedby><cites>FETCH-LOGICAL-a307t-744e47d48d55ee93226803c80fd1bb0b601d7a352b5a87058219bc9a2928978f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ed1006053$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ed1006053$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2756,27067,27915,27916,56729,56779</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ941052$$DView record in ERIC$$Hfree_for_read</backlink></links><search><creatorcontrib>Mead, Ralph N</creatorcontrib><creatorcontrib>Seaton, Pamela J</creatorcontrib><title>GC–MS Quantitation and Identification of Bisphenol-A Isolated from Water</title><title>Journal of chemical education</title><addtitle>J. Chem. Educ</addtitle><description>Isolation and identification of organic compounds is a necessary skill chemistry students must be able to do with proficiency. In this upper-level undergraduate laboratory, students isolate bisphenol-A (BPA; 4-4′-isopropylidenediphenol) from water using solid-phase extraction (SPE) followed by derivatization with analysis by GC–MS. The students learn the proper steps and techniques of SPE that include conditioning, equilibration, washing, and eluting. The students are then asked to identify the BPA peak from the GC–MS analysis of a mixture of standards based upon the molecular ion, keeping in mind the change in molecular weight upon derivatization. Interpretation of GC–MS data showed predictable fragmentation and highlights the formation of benzylic carbocations. Quantification was done by an external calibration curve and the sample was quantified and a percent recovery is calculated.</description><subject>Bisphenol A</subject><subject>Chemical compounds</subject><subject>College Science</subject><subject>College students</subject><subject>Conditioning</subject><subject>Extraction processes</subject><subject>Identification</subject><subject>Ions</subject><subject>Molecular ions</subject><subject>Molecular Structure</subject><subject>Molecular weight</subject><subject>Organic Chemistry</subject><subject>Organic compounds</subject><subject>Science Instruction</subject><subject>Science Laboratories</subject><subject>Science Process Skills</subject><subject>Scientific Principles</subject><subject>Solid phases</subject><subject>Students</subject><subject>Undergraduate Study</subject><subject>Water</subject><issn>0021-9584</issn><issn>1938-1328</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNplkM1KAzEUhYMoWKsL9y6C4MLF6M3fTLKspdYWRUTF5ZCZJDilndRkunDnO_iGPomRkbpwdS_nfJwDB6FjAhcEKLm0hgDkINgOGhDFZEYYlbtoAMnMlJB8Hx3EuAAgVCg5QPPp-Ovj8-4RP2x02zWd7hrfYt0aPDM2Ca6pe8k7fNXE9att_TIb4Vn0S91Zg13wK_yS3nCI9pxeRnv0e4fo-XryNL7Jbu-ns_HoNtMMii4rOLe8MFwaIaxVjNJcAqslOEOqCqociCk0E7QSWhYgJCWqqpWmikpVSMeG6LTPXQf_trGxKxd-E9pUWUrJCZN5LhJ03kN18DEG68p1aFY6vJcEyp-lyu1SiT3pWRuaestN5ooTEDTZZ72t6_hX9T_mG_U3bmE</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Mead, Ralph N</creator><creator>Seaton, Pamela J</creator><general>American Chemical Society and Division of Chemical Education, Inc</general><general>Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society</general><general>American Chemical Society</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20110801</creationdate><title>GC–MS Quantitation and Identification of Bisphenol-A Isolated from Water</title><author>Mead, Ralph N ; Seaton, Pamela J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a307t-744e47d48d55ee93226803c80fd1bb0b601d7a352b5a87058219bc9a2928978f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bisphenol A</topic><topic>Chemical compounds</topic><topic>College Science</topic><topic>College students</topic><topic>Conditioning</topic><topic>Extraction processes</topic><topic>Identification</topic><topic>Ions</topic><topic>Molecular ions</topic><topic>Molecular Structure</topic><topic>Molecular weight</topic><topic>Organic Chemistry</topic><topic>Organic compounds</topic><topic>Science Instruction</topic><topic>Science Laboratories</topic><topic>Science Process Skills</topic><topic>Scientific Principles</topic><topic>Solid phases</topic><topic>Students</topic><topic>Undergraduate Study</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mead, Ralph N</creatorcontrib><creatorcontrib>Seaton, Pamela J</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of chemical education</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mead, Ralph N</au><au>Seaton, Pamela J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ941052</ericid><atitle>GC–MS Quantitation and Identification of Bisphenol-A Isolated from Water</atitle><jtitle>Journal of chemical education</jtitle><addtitle>J. Chem. Educ</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>88</volume><issue>8</issue><spage>1130</spage><epage>1132</epage><pages>1130-1132</pages><issn>0021-9584</issn><eissn>1938-1328</eissn><coden>JCEDA8</coden><abstract>Isolation and identification of organic compounds is a necessary skill chemistry students must be able to do with proficiency. In this upper-level undergraduate laboratory, students isolate bisphenol-A (BPA; 4-4′-isopropylidenediphenol) from water using solid-phase extraction (SPE) followed by derivatization with analysis by GC–MS. The students learn the proper steps and techniques of SPE that include conditioning, equilibration, washing, and eluting. The students are then asked to identify the BPA peak from the GC–MS analysis of a mixture of standards based upon the molecular ion, keeping in mind the change in molecular weight upon derivatization. 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| source | ACS Publications |
| subjects | Bisphenol A Chemical compounds College Science College students Conditioning Extraction processes Identification Ions Molecular ions Molecular Structure Molecular weight Organic Chemistry Organic compounds Science Instruction Science Laboratories Science Process Skills Scientific Principles Solid phases Students Undergraduate Study Water |
| title | GC–MS Quantitation and Identification of Bisphenol-A Isolated from Water |
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