Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria
Vitamin B6 metabolites and their potential correlates to urinary oxalate excretion in idiopathic calcium stone formers (ICSF) compared with healthy subjects were investigated. This clinical study was performed in a population of male ICSF with (Hyperoxalurics, n=55) or without hyperoxaluria (Normoox...
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| Veröffentlicht in: | Urolithiasis 2004-02, Vol.32 (1), p.61-68 |
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| creator | Kaelin, Agnes Casez, Jean-Paul Jaeger, Philippe |
| description | Vitamin B6 metabolites and their potential correlates to urinary oxalate excretion in idiopathic calcium stone formers (ICSF) compared with healthy subjects were investigated. This clinical study was performed in a population of male ICSF with (Hyperoxalurics, n=55) or without hyperoxaluria (Normooxalurics, n=57) as well as in 100 healthy male control subjects. Pyridoxal 5'-phosphate serum concentration (S-pyridoxal 5'P) and 24-h urinary excretion of 4-pyridoxic acid (U-4pyridoxic acid) were measured using HPLC; 24-h urinary excretion of oxalate (U-oxalate) was measured concurrently. A subgroup of subjects (40 Hyperoxalurics, 15 Normooxalurics and 50 controls) underwent the same measurements before and after 7-day pyridoxine loading per os (pyridoxine hydrochloride, 300 mg/d). Under usual conditions, U-4pyridoxic acid was similar in the three groups, whereas mean S-pyridoxal 5'P was significantly lower ( p |
| doi_str_mv | 10.1007/s00240-003-0386-2 |
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This clinical study was performed in a population of male ICSF with (Hyperoxalurics, n=55) or without hyperoxaluria (Normooxalurics, n=57) as well as in 100 healthy male control subjects. Pyridoxal 5'-phosphate serum concentration (S-pyridoxal 5'P) and 24-h urinary excretion of 4-pyridoxic acid (U-4pyridoxic acid) were measured using HPLC; 24-h urinary excretion of oxalate (U-oxalate) was measured concurrently. A subgroup of subjects (40 Hyperoxalurics, 15 Normooxalurics and 50 controls) underwent the same measurements before and after 7-day pyridoxine loading per os (pyridoxine hydrochloride, 300 mg/d). Under usual conditions, U-4pyridoxic acid was similar in the three groups, whereas mean S-pyridoxal 5'P was significantly lower ( p<0.0001) in the Hyperoxalurics (59.6+/-21.2 nmol/L) and in the Normooxalurics (64.9+/-19.7 nmol/L) than in the controls (86.0+/-31.0 nmol/L). No correlation could be found between U-oxalate and U-4pyridoxic acid or S-pyridoxal 5'P. After B6 loading, S-pyridoxal 5'P was still significantly lower in the Hyperoxalurics (415+/-180 nmol/L, p<0.001) and in the Normooxalurics (429+/-115 nmol/L, p=0.036) than in the controls (546+/-180 nmol/L), although there was no difference between groups for U-4pyridoxic acid. No correlation in any group could be found between changes in U-oxalate and changes in U-4pyridoxic acid or S-pyridoxal 5'P. Although there is no vitamin B6 deficiency in ICSF with or without hyperoxaluria, these patients, on average, have lower levels of S-pyridoxal 5'P than healthy subjects. However, this slight decrease does not seem to account for idiopathic hyperoxaluria.</description><identifier>ISSN: 0300-5623</identifier><identifier>ISSN: 2194-7228</identifier><identifier>EISSN: 1434-0879</identifier><identifier>EISSN: 2194-7236</identifier><identifier>DOI: 10.1007/s00240-003-0386-2</identifier><identifier>PMID: 14628106</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Acids ; Adult ; Aged ; Case-Control Studies ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Humans ; Hyperoxaluria - blood ; Hyperoxaluria - complications ; Hyperoxaluria - urine ; Kidney Calculi - blood ; Kidney Calculi - complications ; Kidney Calculi - metabolism ; Kidney Calculi - urine ; Male ; Metabolites ; Middle Aged ; Nutrition ; Oxalates - urine ; Pyridoxal Phosphate - blood ; Pyridoxic Acid - urine ; Pyridoxine - pharmacology ; Vitamin B 6 - metabolism</subject><ispartof>Urolithiasis, 2004-02, Vol.32 (1), p.61-68</ispartof><rights>Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-46e20667eb3bd854a034015633790185a04559b1ca78e51e11c9b829dea8b10f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14628106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaelin, Agnes</creatorcontrib><creatorcontrib>Casez, Jean-Paul</creatorcontrib><creatorcontrib>Jaeger, Philippe</creatorcontrib><title>Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria</title><title>Urolithiasis</title><addtitle>Urol Res</addtitle><description>Vitamin B6 metabolites and their potential correlates to urinary oxalate excretion in idiopathic calcium stone formers (ICSF) compared with healthy subjects were investigated. This clinical study was performed in a population of male ICSF with (Hyperoxalurics, n=55) or without hyperoxaluria (Normooxalurics, n=57) as well as in 100 healthy male control subjects. Pyridoxal 5'-phosphate serum concentration (S-pyridoxal 5'P) and 24-h urinary excretion of 4-pyridoxic acid (U-4pyridoxic acid) were measured using HPLC; 24-h urinary excretion of oxalate (U-oxalate) was measured concurrently. A subgroup of subjects (40 Hyperoxalurics, 15 Normooxalurics and 50 controls) underwent the same measurements before and after 7-day pyridoxine loading per os (pyridoxine hydrochloride, 300 mg/d). Under usual conditions, U-4pyridoxic acid was similar in the three groups, whereas mean S-pyridoxal 5'P was significantly lower ( p<0.0001) in the Hyperoxalurics (59.6+/-21.2 nmol/L) and in the Normooxalurics (64.9+/-19.7 nmol/L) than in the controls (86.0+/-31.0 nmol/L). No correlation could be found between U-oxalate and U-4pyridoxic acid or S-pyridoxal 5'P. After B6 loading, S-pyridoxal 5'P was still significantly lower in the Hyperoxalurics (415+/-180 nmol/L, p<0.001) and in the Normooxalurics (429+/-115 nmol/L, p=0.036) than in the controls (546+/-180 nmol/L), although there was no difference between groups for U-4pyridoxic acid. No correlation in any group could be found between changes in U-oxalate and changes in U-4pyridoxic acid or S-pyridoxal 5'P. Although there is no vitamin B6 deficiency in ICSF with or without hyperoxaluria, these patients, on average, have lower levels of S-pyridoxal 5'P than healthy subjects. However, this slight decrease does not seem to account for idiopathic hyperoxaluria.</description><subject>Acids</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Hyperoxaluria - blood</subject><subject>Hyperoxaluria - complications</subject><subject>Hyperoxaluria - urine</subject><subject>Kidney Calculi - blood</subject><subject>Kidney Calculi - complications</subject><subject>Kidney Calculi - metabolism</subject><subject>Kidney Calculi - urine</subject><subject>Male</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Oxalates - urine</subject><subject>Pyridoxal Phosphate - blood</subject><subject>Pyridoxic Acid - urine</subject><subject>Pyridoxine - pharmacology</subject><subject>Vitamin B 6 - metabolism</subject><issn>0300-5623</issn><issn>2194-7228</issn><issn>1434-0879</issn><issn>2194-7236</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkE1r3DAURUVpaCZpf0A3RXSRnZP3JFmWu2tCviCQTZKtkOVnRlPbmkp2SP59nMxAoasHl3Mvj8PYd4RTBKjOMoBQUADIAqTRhfjEVqikKsBU9We2AglQlFrIQ3aU8wYAK12LL-wQlRYGQa-YfwqTG8LIzzUfaHJN7MNEmS9JaEPcumkdPPeu92EeeJ7iSLyLaaCUf_ExcnoOLY3-I-SO92H8w6fI169bSvHF9XMK7is76Fyf6dv-HrPHq8uHi5vi7v769uL3XeGlUFOhNAnQuqJGNq0plQOpAEstZVUDmtKBKsu6Qe8qQyUSoq8bI-qWnGkQOnnMTna72xT_zpQnO4Tsqe_dSHHOtkJt6mVqAX_-B27inMblN2uMQolKlQuEO8inmHOizm5TGFx6tQj2Xb_d6beLfvuu34ql82M_PDcDtf8ae9_yDeQffvo</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Kaelin, Agnes</creator><creator>Casez, Jean-Paul</creator><creator>Jaeger, Philippe</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200402</creationdate><title>Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria</title><author>Kaelin, Agnes ; Casez, Jean-Paul ; Jaeger, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-46e20667eb3bd854a034015633790185a04559b1ca78e51e11c9b829dea8b10f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Hyperoxaluria - blood</topic><topic>Hyperoxaluria - complications</topic><topic>Hyperoxaluria - urine</topic><topic>Kidney Calculi - blood</topic><topic>Kidney Calculi - complications</topic><topic>Kidney Calculi - metabolism</topic><topic>Kidney Calculi - urine</topic><topic>Male</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Oxalates - urine</topic><topic>Pyridoxal Phosphate - blood</topic><topic>Pyridoxic Acid - urine</topic><topic>Pyridoxine - pharmacology</topic><topic>Vitamin B 6 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaelin, Agnes</creatorcontrib><creatorcontrib>Casez, Jean-Paul</creatorcontrib><creatorcontrib>Jaeger, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Urolithiasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaelin, Agnes</au><au>Casez, Jean-Paul</au><au>Jaeger, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria</atitle><jtitle>Urolithiasis</jtitle><addtitle>Urol Res</addtitle><date>2004-02</date><risdate>2004</risdate><volume>32</volume><issue>1</issue><spage>61</spage><epage>68</epage><pages>61-68</pages><issn>0300-5623</issn><issn>2194-7228</issn><eissn>1434-0879</eissn><eissn>2194-7236</eissn><abstract>Vitamin B6 metabolites and their potential correlates to urinary oxalate excretion in idiopathic calcium stone formers (ICSF) compared with healthy subjects were investigated. This clinical study was performed in a population of male ICSF with (Hyperoxalurics, n=55) or without hyperoxaluria (Normooxalurics, n=57) as well as in 100 healthy male control subjects. Pyridoxal 5'-phosphate serum concentration (S-pyridoxal 5'P) and 24-h urinary excretion of 4-pyridoxic acid (U-4pyridoxic acid) were measured using HPLC; 24-h urinary excretion of oxalate (U-oxalate) was measured concurrently. A subgroup of subjects (40 Hyperoxalurics, 15 Normooxalurics and 50 controls) underwent the same measurements before and after 7-day pyridoxine loading per os (pyridoxine hydrochloride, 300 mg/d). Under usual conditions, U-4pyridoxic acid was similar in the three groups, whereas mean S-pyridoxal 5'P was significantly lower ( p<0.0001) in the Hyperoxalurics (59.6+/-21.2 nmol/L) and in the Normooxalurics (64.9+/-19.7 nmol/L) than in the controls (86.0+/-31.0 nmol/L). No correlation could be found between U-oxalate and U-4pyridoxic acid or S-pyridoxal 5'P. After B6 loading, S-pyridoxal 5'P was still significantly lower in the Hyperoxalurics (415+/-180 nmol/L, p<0.001) and in the Normooxalurics (429+/-115 nmol/L, p=0.036) than in the controls (546+/-180 nmol/L), although there was no difference between groups for U-4pyridoxic acid. No correlation in any group could be found between changes in U-oxalate and changes in U-4pyridoxic acid or S-pyridoxal 5'P. Although there is no vitamin B6 deficiency in ICSF with or without hyperoxaluria, these patients, on average, have lower levels of S-pyridoxal 5'P than healthy subjects. However, this slight decrease does not seem to account for idiopathic hyperoxaluria.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>14628106</pmid><doi>10.1007/s00240-003-0386-2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Urolithiasis, 2004-02, Vol.32 (1), p.61-68 |
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| subjects | Acids Adult Aged Case-Control Studies Chromatography, High Pressure Liquid Cross-Sectional Studies Humans Hyperoxaluria - blood Hyperoxaluria - complications Hyperoxaluria - urine Kidney Calculi - blood Kidney Calculi - complications Kidney Calculi - metabolism Kidney Calculi - urine Male Metabolites Middle Aged Nutrition Oxalates - urine Pyridoxal Phosphate - blood Pyridoxic Acid - urine Pyridoxine - pharmacology Vitamin B 6 - metabolism |
| title | Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria |
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