Targeting fibromyalgia pain: brain-spinal cord and peripheral contributions
Fibromyalgia (FM) is a complex chronic pain syndrome with a well-defined clinical phenotype that results from disordered central pain-related mechanisms. The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskel...
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| Veröffentlicht in: | International Journal of Clinical Rheumatology 2011-08, Vol.6 (4), p.463-474 |
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| container_end_page | 474 |
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| container_title | International Journal of Clinical Rheumatology |
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| creator | Franklyn, Kate Louise Guymer, Emma Kathryn Littlejohn, Geoffrey Owen |
| description | Fibromyalgia (FM) is a complex chronic pain syndrome with a well-defined clinical phenotype that results from disordered central pain-related mechanisms. The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms. |
| doi_str_mv | 10.2217/ijr.11.41 |
| format | Article |
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The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms.</description><identifier>ISSN: 1758-4272</identifier><identifier>EISSN: 1758-4280</identifier><identifier>DOI: 10.2217/ijr.11.41</identifier><language>eng</language><publisher>London: Future Medicine Ltd</publisher><subject>brain ; Care and treatment ; Chronic pain ; Development and progression ; diffuse noxious inhibitory control ; DNIC ; Fatigue ; Fibromyalgia ; Pain ; psychological ; spinal cord ; stress ; Stress (Psychology)</subject><ispartof>International Journal of Clinical Rheumatology, 2011-08, Vol.6 (4), p.463-474</ispartof><rights>COPYRIGHT 2011 Future Medicine Ltd.</rights><rights>2011 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c244t-4f0e2b06c61a772a68ec1a6e9d1db1a46ca6d2029b35022eeb27bd2d59a2c5673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>313,314,780,784,792,27922,27924,27925</link.rule.ids></links><search><creatorcontrib>Franklyn, Kate Louise</creatorcontrib><creatorcontrib>Guymer, Emma Kathryn</creatorcontrib><creatorcontrib>Littlejohn, Geoffrey Owen</creatorcontrib><title>Targeting fibromyalgia pain: brain-spinal cord and peripheral contributions</title><title>International Journal of Clinical Rheumatology</title><description>Fibromyalgia (FM) is a complex chronic pain syndrome with a well-defined clinical phenotype that results from disordered central pain-related mechanisms. The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms.</description><subject>brain</subject><subject>Care and treatment</subject><subject>Chronic pain</subject><subject>Development and progression</subject><subject>diffuse noxious inhibitory control</subject><subject>DNIC</subject><subject>Fatigue</subject><subject>Fibromyalgia</subject><subject>Pain</subject><subject>psychological</subject><subject>spinal cord</subject><subject>stress</subject><subject>Stress (Psychology)</subject><issn>1758-4272</issn><issn>1758-4280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1PwzAMhisEEhPswD-o4MShI_HStOU2TXyJSVzGOUoTd3ha05K0h_17uhUhIc0--EPPa9lyFN1wNgPg2QNt_YzzmeBn0YRnaZ4IyNn5X57BZTQNYcsGm3ORF2wSva-132BHbhNXVPqm3uvdhnTcanKPcemHkISWnN7FpvE21s7GLXpqv9Afe67zVPYdNS5cRxeV3gWc_sar6PP5ab18TVYfL2_LxSoxIESXiIohlEwayXWWgZY5Gq4lFpbbkmshjZYWGBTlPGUAiCVkpQWbFhpMKrP5VXQ7zm19891j6NS26f2wYlB5LjjIdM4H6G6ENnqHilzVdF6bmoJRC5AZQJGKAzU7QQ1usabhOKxo6P8T3I8C45sQPFaq9VRrv1ecqcMT1PAExbk6sunIVn3XewyG0BlUY1WjJUMOT-h-AFbWi3I</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Franklyn, Kate Louise</creator><creator>Guymer, Emma Kathryn</creator><creator>Littlejohn, Geoffrey Owen</creator><general>Future Medicine Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20110801</creationdate><title>Targeting fibromyalgia pain: brain-spinal cord and peripheral contributions</title><author>Franklyn, Kate Louise ; 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The etiology is multifaceted with links to genetic factors, personality, psychological distress, environmental triggers and peripheral musculoskeletal function. Central brain and spinal cord 'top-down mechanisms dominate the pathophysiology of FM. We review the disordered pain-related neurological processes that are present in FM and discuss treatments that target these relevant mechanisms.</abstract><cop>London</cop><pub>Future Medicine Ltd</pub><doi>10.2217/ijr.11.41</doi><tpages>12</tpages></addata></record> |
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| ispartof | International Journal of Clinical Rheumatology, 2011-08, Vol.6 (4), p.463-474 |
| issn | 1758-4272 1758-4280 |
| language | eng |
| recordid | cdi_proquest_journals_884126531 |
| source | Alma/SFX Local Collection |
| subjects | brain Care and treatment Chronic pain Development and progression diffuse noxious inhibitory control DNIC Fatigue Fibromyalgia Pain psychological spinal cord stress Stress (Psychology) |
| title | Targeting fibromyalgia pain: brain-spinal cord and peripheral contributions |
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