Assessment of the emetogenic potential of intrathecal chemotherapy and response to prophylactic treatment with ondansetron

The purpose of this study was to document the emetogenic potential of intrathecal chemotherapy (IC) in children and to evaluate the efficacy of ondansetron in reducing nausea and vomiting with this chemotherapy treatment. Patients less than 18 years of age with acute lymphoblastic leukemia were elig...

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Veröffentlicht in:	Supportive care in cancer 1998-03, Vol.6 (2), p.132-138
Hauptverfasser:	HOLDSWORTH, M. T, RAISCH, D. W, WINTER, S. S, CHAVEZ, C. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiemetics - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Chemotherapy Child Child, Preschool Cytarabine - administration & dosage Cytarabine - adverse effects Drug toxicity and drugs side effects treatment Female Humans Hydrocortisone - administration & dosage Hydrocortisone - adverse effects Injections, Spinal Male Medical sciences Methotrexate - administration & dosage Methotrexate - adverse effects Nausea Nausea - chemically induced Nausea - drug therapy Ondansetron - therapeutic use Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Statistical analysis Toxicity: digestive system Treatment Outcome
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