The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies
Background Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far. Materials and methods We conducted two clinical trials testing the LEL...
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| Veröffentlicht in: | Supportive care in cancer 2008-12, Vol.16 (12), p.1381-1387 |
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| creator | Genot-Klastersky, M. T. Klastersky, J. Awada, F. Awada, A. Crombez, P. Martinez, M. D. Jaivenois, M. F. Delmelle, M. Vogt, G. Meuleman, N. Paesmans, M. |
| description | Background
Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far.
Materials and methods
We conducted two clinical trials testing the LEL technique: firstly, as a secondary prevention in patients with various solid tumors treated with chemotherapy who all developed severe mucositis after a previous identical chemotherapy and, secondly, as therapeutic intervention (compared to sham illumination in a randomized way) in patients with hematological tumors receiving intensive chemotherapy and having developed low-grade oral mucositis.
Results
We entered 26 eligible patients in the first study and 36 were randomized in the second study. The success rate was 81% (95%CI = 61–93%) when LEL was given as a preventive treatment. In the second study, in patients with existing lesions, the therapeutic success rate was 83% (95%CI = 59–96%), which was significantly different from the success rate reached in the sham-treated patients (11%; 95%CI = 1–35%); the time to development of grade 3 mucositis was also significantly shorter in the sham-treated patients (
p
|
| doi_str_mv | 10.1007/s00520-008-0439-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_884093969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2427928611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-a39733c5d2eb948f382b038b55b77c6cecabad45a5cbc0e536175066765f485d3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EotuWB-CCLE5wcGvHdmJzQ1UplVbi0p4tx560rpI42E6rfSTeEq92RU-cRpr55v9n9CP0kdELRml3mSmVDSWUKkIF10S9QRsmOCcd5_ot2lAtGBFcyhN0mvMTpazrZPMenTAlpNKt2KA_d4-A1ww4DniMLwRmSA87PNoMCX_ZXm-_4iEmXCq1JHiGuYQ472H3CFOs7WSXHcF29pcVS9aHf80w-9WBxzHZEU-rizmUkHGYsbOzq_KLLaEK5m84QV7HkvGQ4oTLS6xeMS_gSngGnMvqA-Rz9G6wY4YPx3qG7n9c3139JNtfN7dX37fE8VYXYrmu3zvpG-i1UANXTU-56qXsu861DpztrRfSStc7CpK3rJO0bbtWDkJJz8_Q54NuveH3CrmYp7imuVoapQTVXLe6QuwAuXpoTjCYJYXJpp1h1OyzMYdsTM3G7LMxqu58Ogqv_QT-deMYRgWaA5DraH6A9Or8f9W_deec-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>884093969</pqid></control><display><type>article</type><title>The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Genot-Klastersky, M. T. ; Klastersky, J. ; Awada, F. ; Awada, A. ; Crombez, P. ; Martinez, M. D. ; Jaivenois, M. F. ; Delmelle, M. ; Vogt, G. ; Meuleman, N. ; Paesmans, M.</creator><creatorcontrib>Genot-Klastersky, M. T. ; Klastersky, J. ; Awada, F. ; Awada, A. ; Crombez, P. ; Martinez, M. D. ; Jaivenois, M. F. ; Delmelle, M. ; Vogt, G. ; Meuleman, N. ; Paesmans, M.</creatorcontrib><description>Background
Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far.
Materials and methods
We conducted two clinical trials testing the LEL technique: firstly, as a secondary prevention in patients with various solid tumors treated with chemotherapy who all developed severe mucositis after a previous identical chemotherapy and, secondly, as therapeutic intervention (compared to sham illumination in a randomized way) in patients with hematological tumors receiving intensive chemotherapy and having developed low-grade oral mucositis.
Results
We entered 26 eligible patients in the first study and 36 were randomized in the second study. The success rate was 81% (95%CI = 61–93%) when LEL was given as a preventive treatment. In the second study, in patients with existing lesions, the therapeutic success rate was 83% (95%CI = 59–96%), which was significantly different from the success rate reached in the sham-treated patients (11%; 95%CI = 1–35%); the time to development of grade 3 mucositis was also significantly shorter in the sham-treated patients (
p
< 0.001).
Conclusion
Our results strongly support the already available literature, suggesting that LEL is an effective and safe approach to prevent or treat oral mucositis resulting from cancer chemotherapy.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-008-0439-8</identifier><identifier>PMID: 18458964</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Antineoplastic Agents - adverse effects ; Cancer ; Chemotherapy ; Female ; Humans ; Low-Level Light Therapy ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Prospective Studies ; Radiation therapy ; Radiotherapy - adverse effects ; Rehabilitation Medicine ; Secondary Prevention ; Stomatitis - etiology ; Stomatitis - prevention & control ; Stomatitis - radiotherapy ; Young Adult</subject><ispartof>Supportive care in cancer, 2008-12, Vol.16 (12), p.1381-1387</ispartof><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-a39733c5d2eb948f382b038b55b77c6cecabad45a5cbc0e536175066765f485d3</citedby><cites>FETCH-LOGICAL-c369t-a39733c5d2eb948f382b038b55b77c6cecabad45a5cbc0e536175066765f485d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-008-0439-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-008-0439-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18458964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Genot-Klastersky, M. T.</creatorcontrib><creatorcontrib>Klastersky, J.</creatorcontrib><creatorcontrib>Awada, F.</creatorcontrib><creatorcontrib>Awada, A.</creatorcontrib><creatorcontrib>Crombez, P.</creatorcontrib><creatorcontrib>Martinez, M. D.</creatorcontrib><creatorcontrib>Jaivenois, M. F.</creatorcontrib><creatorcontrib>Delmelle, M.</creatorcontrib><creatorcontrib>Vogt, G.</creatorcontrib><creatorcontrib>Meuleman, N.</creatorcontrib><creatorcontrib>Paesmans, M.</creatorcontrib><title>The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Background
Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far.
Materials and methods
We conducted two clinical trials testing the LEL technique: firstly, as a secondary prevention in patients with various solid tumors treated with chemotherapy who all developed severe mucositis after a previous identical chemotherapy and, secondly, as therapeutic intervention (compared to sham illumination in a randomized way) in patients with hematological tumors receiving intensive chemotherapy and having developed low-grade oral mucositis.
Results
We entered 26 eligible patients in the first study and 36 were randomized in the second study. The success rate was 81% (95%CI = 61–93%) when LEL was given as a preventive treatment. In the second study, in patients with existing lesions, the therapeutic success rate was 83% (95%CI = 59–96%), which was significantly different from the success rate reached in the sham-treated patients (11%; 95%CI = 1–35%); the time to development of grade 3 mucositis was also significantly shorter in the sham-treated patients (
p
< 0.001).
Conclusion
Our results strongly support the already available literature, suggesting that LEL is an effective and safe approach to prevent or treat oral mucositis resulting from cancer chemotherapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Prospective Studies</subject><subject>Radiation therapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Rehabilitation Medicine</subject><subject>Secondary Prevention</subject><subject>Stomatitis - etiology</subject><subject>Stomatitis - prevention & control</subject><subject>Stomatitis - radiotherapy</subject><subject>Young Adult</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFu1DAQhi0EotuWB-CCLE5wcGvHdmJzQ1UplVbi0p4tx560rpI42E6rfSTeEq92RU-cRpr55v9n9CP0kdELRml3mSmVDSWUKkIF10S9QRsmOCcd5_ot2lAtGBFcyhN0mvMTpazrZPMenTAlpNKt2KA_d4-A1ww4DniMLwRmSA87PNoMCX_ZXm-_4iEmXCq1JHiGuYQ472H3CFOs7WSXHcF29pcVS9aHf80w-9WBxzHZEU-rizmUkHGYsbOzq_KLLaEK5m84QV7HkvGQ4oTLS6xeMS_gSngGnMvqA-Rz9G6wY4YPx3qG7n9c3139JNtfN7dX37fE8VYXYrmu3zvpG-i1UANXTU-56qXsu861DpztrRfSStc7CpK3rJO0bbtWDkJJz8_Q54NuveH3CrmYp7imuVoapQTVXLe6QuwAuXpoTjCYJYXJpp1h1OyzMYdsTM3G7LMxqu58Ogqv_QT-deMYRgWaA5DraH6A9Or8f9W_deec-Q</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Genot-Klastersky, M. T.</creator><creator>Klastersky, J.</creator><creator>Awada, F.</creator><creator>Awada, A.</creator><creator>Crombez, P.</creator><creator>Martinez, M. D.</creator><creator>Jaivenois, M. 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T. ; Klastersky, J. ; Awada, F. ; Awada, A. ; Crombez, P. ; Martinez, M. D. ; Jaivenois, M. 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F.</creatorcontrib><creatorcontrib>Delmelle, M.</creatorcontrib><creatorcontrib>Vogt, G.</creatorcontrib><creatorcontrib>Meuleman, N.</creatorcontrib><creatorcontrib>Paesmans, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genot-Klastersky, M. T.</au><au>Klastersky, J.</au><au>Awada, F.</au><au>Awada, A.</au><au>Crombez, P.</au><au>Martinez, M. D.</au><au>Jaivenois, M. F.</au><au>Delmelle, M.</au><au>Vogt, G.</au><au>Meuleman, N.</au><au>Paesmans, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>16</volume><issue>12</issue><spage>1381</spage><epage>1387</epage><pages>1381-1387</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Background
Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far.
Materials and methods
We conducted two clinical trials testing the LEL technique: firstly, as a secondary prevention in patients with various solid tumors treated with chemotherapy who all developed severe mucositis after a previous identical chemotherapy and, secondly, as therapeutic intervention (compared to sham illumination in a randomized way) in patients with hematological tumors receiving intensive chemotherapy and having developed low-grade oral mucositis.
Results
We entered 26 eligible patients in the first study and 36 were randomized in the second study. The success rate was 81% (95%CI = 61–93%) when LEL was given as a preventive treatment. In the second study, in patients with existing lesions, the therapeutic success rate was 83% (95%CI = 59–96%), which was significantly different from the success rate reached in the sham-treated patients (11%; 95%CI = 1–35%); the time to development of grade 3 mucositis was also significantly shorter in the sham-treated patients (
p
< 0.001).
Conclusion
Our results strongly support the already available literature, suggesting that LEL is an effective and safe approach to prevent or treat oral mucositis resulting from cancer chemotherapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18458964</pmid><doi>10.1007/s00520-008-0439-8</doi><tpages>7</tpages></addata></record> |
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| issn | 0941-4355 1433-7339 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Antineoplastic Agents - adverse effects Cancer Chemotherapy Female Humans Low-Level Light Therapy Male Medicine Medicine & Public Health Middle Aged Nursing Nursing Research Oncology Original Article Pain Medicine Prospective Studies Radiation therapy Radiotherapy - adverse effects Rehabilitation Medicine Secondary Prevention Stomatitis - etiology Stomatitis - prevention & control Stomatitis - radiotherapy Young Adult |
| title | The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies |
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