Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer
Both experimental and epidemiological evidence support the concept that the in utero environment can influence an individual's risk of breast cancer in adult life. Recently identified breast stem cells may be the key to understanding the mechanism underlying this phenomenon. It has been theoriz...
Gespeichert in:
| Veröffentlicht in: | Stem cell reviews 2006-06, Vol.2 (2), p.103-109 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109 |
|---|---|
| container_issue | 2 |
| container_start_page | 103 |
| container_title | Stem cell reviews |
| container_volume | 2 |
| creator | Savarese, Todd M Low, Hoi Pang Baik, Inkyung Strohsnitter, William C Hsieh, Chung-Cheng |
| description | Both experimental and epidemiological evidence support the concept that the in utero environment can influence an individual's risk of breast cancer in adult life. Recently identified breast stem cells may be the key to understanding the mechanism underlying this phenomenon. It has been theorized that breast cancers arise from breast stem cells. Our emerging view of the characteristics of normal breast stem cells and their link to malignant breast stem cells is reviewed here. It has also been postulated that factors that expand the normal breast stem cell pool in utero would increase the probability that one such cell might undergo an oncogenic mutation or epigenetic change. We discuss how a number of proposed perinatal determinants of adult breast cancer risk, including (1) in utero estrogen and IGF-1 levels, (2) birthweight, (3) breast density, and (4) early-life mutagen exposure, can be tied together by this "breast stem cell burden" hypothesis. |
| doi_str_mv | 10.1007/s12015-006-0016-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_883664956</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2426613471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c287t-681f9b3f350348dd33336d7b920eacc48c1fee7d9c231de164088201af8717f43</originalsourceid><addsrcrecordid>eNptkE9PxCAQxYnRuOvqB_BiGg-erDKFAj2ajf-SjV70jJTC2k1LV6AHv72su8bESDKBzPzm5fEQOgV8BRjz6wAFhjLHmKUClld7aAplKXImMN3_fuNcVJRM0FEIK4yJoAIO0QR4QXhJxRS9PQ2-V11We6NCzEI0faZN14XLLLXbpVMu_jdUrsniu8nWxrdOxaQw-HbZumywP7hWTht_jA6s6oI52d0z9Hp3-zJ_yBfP94_zm0WuC8Fjcgy2qoklJSZUNA1JhzW8rgpslNZUaLDG8KbSBYHGAKNYiPR7ZQUHbimZoYut7toPH6MJUfZt2JhVzgxjkAVgyoQQCTz_A66G0bvkTaYpY7QqWYJgC2k_hOCNlWvf9sp_SsByk73cZi9T9nKTvazSztlOeKx70_xu7MImX5OefmY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>883664956</pqid></control><display><type>article</type><title>Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Savarese, Todd M ; Low, Hoi Pang ; Baik, Inkyung ; Strohsnitter, William C ; Hsieh, Chung-Cheng</creator><creatorcontrib>Savarese, Todd M ; Low, Hoi Pang ; Baik, Inkyung ; Strohsnitter, William C ; Hsieh, Chung-Cheng</creatorcontrib><description>Both experimental and epidemiological evidence support the concept that the in utero environment can influence an individual's risk of breast cancer in adult life. Recently identified breast stem cells may be the key to understanding the mechanism underlying this phenomenon. It has been theorized that breast cancers arise from breast stem cells. Our emerging view of the characteristics of normal breast stem cells and their link to malignant breast stem cells is reviewed here. It has also been postulated that factors that expand the normal breast stem cell pool in utero would increase the probability that one such cell might undergo an oncogenic mutation or epigenetic change. We discuss how a number of proposed perinatal determinants of adult breast cancer risk, including (1) in utero estrogen and IGF-1 levels, (2) birthweight, (3) breast density, and (4) early-life mutagen exposure, can be tied together by this "breast stem cell burden" hypothesis.</description><identifier>ISSN: 1550-8943</identifier><identifier>ISSN: 2629-3269</identifier><identifier>EISSN: 1558-6804</identifier><identifier>EISSN: 2629-3277</identifier><identifier>DOI: 10.1007/s12015-006-0016-9</identifier><identifier>PMID: 17237548</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Birth weight ; Breast - cytology ; Breast cancer ; Breast Neoplasms - pathology ; Epidemiology ; Epigenetics ; Epithelial Cells - cytology ; Estrogens ; Female ; Humans ; Infant, Newborn ; Insulin-like growth factor I ; Insulin-like growth factors ; Medical research ; Neoplastic Stem Cells - pathology ; Pregnancy ; Stem cells ; Stem Cells - cytology</subject><ispartof>Stem cell reviews, 2006-06, Vol.2 (2), p.103-109</ispartof><rights>Humana Press Inc 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-681f9b3f350348dd33336d7b920eacc48c1fee7d9c231de164088201af8717f43</citedby><cites>FETCH-LOGICAL-c287t-681f9b3f350348dd33336d7b920eacc48c1fee7d9c231de164088201af8717f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17237548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Savarese, Todd M</creatorcontrib><creatorcontrib>Low, Hoi Pang</creatorcontrib><creatorcontrib>Baik, Inkyung</creatorcontrib><creatorcontrib>Strohsnitter, William C</creatorcontrib><creatorcontrib>Hsieh, Chung-Cheng</creatorcontrib><title>Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer</title><title>Stem cell reviews</title><addtitle>Stem Cell Rev</addtitle><description>Both experimental and epidemiological evidence support the concept that the in utero environment can influence an individual's risk of breast cancer in adult life. Recently identified breast stem cells may be the key to understanding the mechanism underlying this phenomenon. It has been theorized that breast cancers arise from breast stem cells. Our emerging view of the characteristics of normal breast stem cells and their link to malignant breast stem cells is reviewed here. It has also been postulated that factors that expand the normal breast stem cell pool in utero would increase the probability that one such cell might undergo an oncogenic mutation or epigenetic change. We discuss how a number of proposed perinatal determinants of adult breast cancer risk, including (1) in utero estrogen and IGF-1 levels, (2) birthweight, (3) breast density, and (4) early-life mutagen exposure, can be tied together by this "breast stem cell burden" hypothesis.</description><subject>Animals</subject><subject>Birth weight</subject><subject>Breast - cytology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Epidemiology</subject><subject>Epigenetics</subject><subject>Epithelial Cells - cytology</subject><subject>Estrogens</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-like growth factors</subject><subject>Medical research</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Pregnancy</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><issn>1550-8943</issn><issn>2629-3269</issn><issn>1558-6804</issn><issn>2629-3277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkE9PxCAQxYnRuOvqB_BiGg-erDKFAj2ajf-SjV70jJTC2k1LV6AHv72su8bESDKBzPzm5fEQOgV8BRjz6wAFhjLHmKUClld7aAplKXImMN3_fuNcVJRM0FEIK4yJoAIO0QR4QXhJxRS9PQ2-V11We6NCzEI0faZN14XLLLXbpVMu_jdUrsniu8nWxrdOxaQw-HbZumywP7hWTht_jA6s6oI52d0z9Hp3-zJ_yBfP94_zm0WuC8Fjcgy2qoklJSZUNA1JhzW8rgpslNZUaLDG8KbSBYHGAKNYiPR7ZQUHbimZoYut7toPH6MJUfZt2JhVzgxjkAVgyoQQCTz_A66G0bvkTaYpY7QqWYJgC2k_hOCNlWvf9sp_SsByk73cZi9T9nKTvazSztlOeKx70_xu7MImX5OefmY</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Savarese, Todd M</creator><creator>Low, Hoi Pang</creator><creator>Baik, Inkyung</creator><creator>Strohsnitter, William C</creator><creator>Hsieh, Chung-Cheng</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7QO</scope></search><sort><creationdate>20060601</creationdate><title>Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer</title><author>Savarese, Todd M ; Low, Hoi Pang ; Baik, Inkyung ; Strohsnitter, William C ; Hsieh, Chung-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-681f9b3f350348dd33336d7b920eacc48c1fee7d9c231de164088201af8717f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Birth weight</topic><topic>Breast - cytology</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Epidemiology</topic><topic>Epigenetics</topic><topic>Epithelial Cells - cytology</topic><topic>Estrogens</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-like growth factors</topic><topic>Medical research</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Pregnancy</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savarese, Todd M</creatorcontrib><creatorcontrib>Low, Hoi Pang</creatorcontrib><creatorcontrib>Baik, Inkyung</creatorcontrib><creatorcontrib>Strohsnitter, William C</creatorcontrib><creatorcontrib>Hsieh, Chung-Cheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Stem cell reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savarese, Todd M</au><au>Low, Hoi Pang</au><au>Baik, Inkyung</au><au>Strohsnitter, William C</au><au>Hsieh, Chung-Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer</atitle><jtitle>Stem cell reviews</jtitle><addtitle>Stem Cell Rev</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>2</volume><issue>2</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>1550-8943</issn><issn>2629-3269</issn><eissn>1558-6804</eissn><eissn>2629-3277</eissn><abstract>Both experimental and epidemiological evidence support the concept that the in utero environment can influence an individual's risk of breast cancer in adult life. Recently identified breast stem cells may be the key to understanding the mechanism underlying this phenomenon. It has been theorized that breast cancers arise from breast stem cells. Our emerging view of the characteristics of normal breast stem cells and their link to malignant breast stem cells is reviewed here. It has also been postulated that factors that expand the normal breast stem cell pool in utero would increase the probability that one such cell might undergo an oncogenic mutation or epigenetic change. We discuss how a number of proposed perinatal determinants of adult breast cancer risk, including (1) in utero estrogen and IGF-1 levels, (2) birthweight, (3) breast density, and (4) early-life mutagen exposure, can be tied together by this "breast stem cell burden" hypothesis.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>17237548</pmid><doi>10.1007/s12015-006-0016-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-8943 |
| ispartof | Stem cell reviews, 2006-06, Vol.2 (2), p.103-109 |
| issn | 1550-8943 2629-3269 1558-6804 2629-3277 |
| language | eng |
| recordid | cdi_proquest_journals_883664956 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Birth weight Breast - cytology Breast cancer Breast Neoplasms - pathology Epidemiology Epigenetics Epithelial Cells - cytology Estrogens Female Humans Infant, Newborn Insulin-like growth factor I Insulin-like growth factors Medical research Neoplastic Stem Cells - pathology Pregnancy Stem cells Stem Cells - cytology |
| title | Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A33%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Normal%20breast%20stem%20cells,%20malignant%20breast%20stem%20cells,%20and%20the%20perinatal%20origin%20of%20breast%20cancer&rft.jtitle=Stem%20cell%20reviews&rft.au=Savarese,%20Todd%20M&rft.date=2006-06-01&rft.volume=2&rft.issue=2&rft.spage=103&rft.epage=109&rft.pages=103-109&rft.issn=1550-8943&rft.eissn=1558-6804&rft_id=info:doi/10.1007/s12015-006-0016-9&rft_dat=%3Cproquest_cross%3E2426613471%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=883664956&rft_id=info:pmid/17237548&rfr_iscdi=true |