p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

A form of programmed cell-death called apoptosis occurs in neurons during development of the nervous system, and may also occur in a variety of neuropathological conditions. Here we present evidence obtained in studies of adult mice and neuronal cell cultures showing that p53 protein is present in s...

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Veröffentlicht in:	Neuromolecular medicine 2003-01, Vol.3 (3), p.159-172
Hauptverfasser:	Gilman, Charles P, Chan, Sic L, Guo, Zhihong, Zhu, Xiaoxiang, Greig, Nigel, Mattson, Mark P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Benzothiazoles Brain - drug effects Brain - metabolism Brain - physiopathology Cell death Cells, Cultured Cellular biology Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - genetics Etoposide Etoposide - pharmacology Excitotoxicity Hippocampus Membrane potential Membrane Potentials - drug effects Membrane Potentials - genetics Mice Mitochondria Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Nervous system Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Neurology Neurons Neuroprotective Agents - pharmacology Neurotoxins - pharmacology Nucleic Acid Synthesis Inhibitors - pharmacology Oxidative Stress - drug effects Oxidative Stress - genetics p53 Protein Phosphorylation Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - pathology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Synapsin I Synapsins - metabolism Synaptosomes Thiazoles - pharmacology Toluene - analogs & derivatives Toluene - pharmacology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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