Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models

The neuropathological hallmarks of Alzheimer's disease (AD) and other taupathies include neurofibrillary tangles and plaques. Despite the fact that only 2-10% of AD cases are associated with genetic mutations, no nontransgenic or metabolic models have been generated to date. The findings of try...

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Veröffentlicht in:	Neuromolecular medicine 2007-02, Vol.9 (1), p.55-82
Hauptverfasser:	Paley, Elena L, Denisova, Galina, Sokolova, Olga, Posternak, Natalia, Wang, Xukui, Brownell, Anna-Liisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Brain - drug effects Brain - metabolism Brain - pathology Cell Count Cell Line, Tumor Glucose - metabolism Hippocampus - metabolism Hippocampus - pathology Humans Male Mice Mice, Inbred BALB C Motor Activity - drug effects Neurodegeneration Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - psychology Neurofibrillary Tangles - pathology Neuroglia - pathology Neurons - pathology Proteins Tryptamines - pharmacology Tryptamines - physiology Tryptophan-tRNA Ligase - antagonists & inhibitors Tryptophan-tRNA Ligase - physiology
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