RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

Background Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in panc...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2011-09, Vol.137 (9), p.1349-1361
Hauptverfasser:	Heinrich, Jörg-Christian, Tuukkanen, Anne, Schroeder, Michael, Fahrig, Torsten, Fahrig, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - mortality Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological and medical sciences Bromodeoxyuridine - administration & dosage Bromodeoxyuridine - analogs & derivatives Bromodeoxyuridine - metabolism Bromodeoxyuridine - pharmacology Cancer Research Chemotherapy Disease Models, Animal Dose-Response Relationship, Drug Double-Blind Method Drug Evaluation, Preclinical Female Gastroenterology. Liver. Pancreas. Abdomen Heat shock proteins Hematology HSP27 Heat-Shock Proteins - metabolism Humans Internal Medicine Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Middle Aged Models, Molecular Oncology Original Paper Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pharmacology. Drug treatments Pilot Projects Placebos Rats Rats, Sprague-Dawley Sarcoma - metabolism Sarcoma - mortality Survival Analysis Tumors
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