Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse
The uterosacral ligaments are thought to contribute to pelvic support. The objective of this study was to compare the structural components of these ligaments in women with and without pelvic organ prolapse (POP). We characterized uterosacral ligaments of 25 postmenopausal women with POP and 16 cont...
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| Veröffentlicht in: | International Urogynecology Journal 2005-12, Vol.16 (6), p.475-479 |
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| creator | Gabriel, Boris Denschlag, Dominik Göbel, Heike Fittkow, Cordula Werner, Martin Gitsch, Gerald Watermann, Dirk |
| description | The uterosacral ligaments are thought to contribute to pelvic support. The objective of this study was to compare the structural components of these ligaments in women with and without pelvic organ prolapse (POP). We characterized uterosacral ligaments of 25 postmenopausal women with POP and 16 controls histomorphologically and immunohistochemically by quantifying their content of collagen I, III, and smooth muscle using a computerized image analysis. In 84% the uterosacral ligaments were composed of more than 20% of smooth muscle cells. There was no difference in collagen I expression and smooth muscle cell amount between women with POP and those without. In contrast, the collagen III expression was significantly related to the presence of POP (p |
| doi_str_mv | 10.1007/s00192-005-1294-5 |
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The objective of this study was to compare the structural components of these ligaments in women with and without pelvic organ prolapse (POP). We characterized uterosacral ligaments of 25 postmenopausal women with POP and 16 controls histomorphologically and immunohistochemically by quantifying their content of collagen I, III, and smooth muscle using a computerized image analysis. In 84% the uterosacral ligaments were composed of more than 20% of smooth muscle cells. There was no difference in collagen I expression and smooth muscle cell amount between women with POP and those without. In contrast, the collagen III expression was significantly related to the presence of POP (p<0.001) rather than age or parity. Our findings suggest that the higher collagen III expression might be a typical characteristic of POP patients' connective tissue. The considerable amount of smooth muscle cells in uterosacral ligaments may provide pelvic support.</description><identifier>ISSN: 0937-3462</identifier><identifier>EISSN: 1433-3023</identifier><identifier>DOI: 10.1007/s00192-005-1294-5</identifier><identifier>PMID: 15846454</identifier><language>eng</language><publisher>England: Springer Nature B.V</publisher><subject>Collagen ; Collagen Type I - metabolism ; Collagen Type III - metabolism ; Female ; Gynecology ; Humans ; Immunohistochemistry ; Ligaments - pathology ; Middle Aged ; Muscular system ; Myocytes, Smooth Muscle - pathology ; Pelvis - pathology ; Postmenopause ; Sacrum ; Uterine Prolapse - pathology ; Uterus ; Women</subject><ispartof>International Urogynecology Journal, 2005-12, Vol.16 (6), p.475-479</ispartof><rights>International Urogynecology Journal 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c295t-b0309a3d0868513893d82b0ea8b1bf3230ff89f5a1a44b67db870bf188e9fd953</citedby><cites>FETCH-LOGICAL-c295t-b0309a3d0868513893d82b0ea8b1bf3230ff89f5a1a44b67db870bf188e9fd953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15846454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabriel, Boris</creatorcontrib><creatorcontrib>Denschlag, Dominik</creatorcontrib><creatorcontrib>Göbel, Heike</creatorcontrib><creatorcontrib>Fittkow, Cordula</creatorcontrib><creatorcontrib>Werner, Martin</creatorcontrib><creatorcontrib>Gitsch, Gerald</creatorcontrib><creatorcontrib>Watermann, Dirk</creatorcontrib><title>Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse</title><title>International Urogynecology Journal</title><addtitle>Int Urogynecol J Pelvic Floor Dysfunct</addtitle><description>The uterosacral ligaments are thought to contribute to pelvic support. The objective of this study was to compare the structural components of these ligaments in women with and without pelvic organ prolapse (POP). We characterized uterosacral ligaments of 25 postmenopausal women with POP and 16 controls histomorphologically and immunohistochemically by quantifying their content of collagen I, III, and smooth muscle using a computerized image analysis. In 84% the uterosacral ligaments were composed of more than 20% of smooth muscle cells. There was no difference in collagen I expression and smooth muscle cell amount between women with POP and those without. In contrast, the collagen III expression was significantly related to the presence of POP (p<0.001) rather than age or parity. Our findings suggest that the higher collagen III expression might be a typical characteristic of POP patients' connective tissue. The considerable amount of smooth muscle cells in uterosacral ligaments may provide pelvic support.</description><subject>Collagen</subject><subject>Collagen Type I - metabolism</subject><subject>Collagen Type III - metabolism</subject><subject>Female</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ligaments - pathology</subject><subject>Middle Aged</subject><subject>Muscular system</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Pelvis - pathology</subject><subject>Postmenopause</subject><subject>Sacrum</subject><subject>Uterine Prolapse - pathology</subject><subject>Uterus</subject><subject>Women</subject><issn>0937-3462</issn><issn>1433-3023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkF1LwzAUhoMork5_gDdSvI-eNEmbXMrwCwaCuOuQtMns6JaatA7_vakbeHW-35fzIHRN4I4AVPcRgMgCA3BMCskwP0EZYZRiCgU9RRlIWmHKymKGLmLcAAADDudoRrhgJeMsQ--rwQYfdR10l3ftWm_tbsjbXd77OKTc93qMabT3qcj37fCZ-_AX_Tjkve2-2zp11jpdBN_pPtpLdOZ0F-3VMc7R6unxY_GCl2_Pr4uHJa4LyQdsgILUtAFRCk6okLQRhQGrhSHG0YKCc0I6rolmzJRVY0QFxhEhrHSN5HSObg-6yfhrtHFQGz-GXbJUQkyCZSnTEjks1enLGKxTfWi3OvwoAmqCqA4QVYKoJohqEr45Co9ma5v_iyM1-gtK2W2S</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Gabriel, Boris</creator><creator>Denschlag, Dominik</creator><creator>Göbel, Heike</creator><creator>Fittkow, Cordula</creator><creator>Werner, Martin</creator><creator>Gitsch, Gerald</creator><creator>Watermann, Dirk</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20051201</creationdate><title>Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse</title><author>Gabriel, Boris ; Denschlag, Dominik ; Göbel, Heike ; Fittkow, Cordula ; Werner, Martin ; Gitsch, Gerald ; Watermann, Dirk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c295t-b0309a3d0868513893d82b0ea8b1bf3230ff89f5a1a44b67db870bf188e9fd953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Collagen</topic><topic>Collagen Type I - metabolism</topic><topic>Collagen Type III - metabolism</topic><topic>Female</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ligaments - pathology</topic><topic>Middle Aged</topic><topic>Muscular system</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Pelvis - pathology</topic><topic>Postmenopause</topic><topic>Sacrum</topic><topic>Uterine Prolapse - pathology</topic><topic>Uterus</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabriel, Boris</creatorcontrib><creatorcontrib>Denschlag, Dominik</creatorcontrib><creatorcontrib>Göbel, Heike</creatorcontrib><creatorcontrib>Fittkow, Cordula</creatorcontrib><creatorcontrib>Werner, Martin</creatorcontrib><creatorcontrib>Gitsch, Gerald</creatorcontrib><creatorcontrib>Watermann, Dirk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International Urogynecology Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabriel, Boris</au><au>Denschlag, Dominik</au><au>Göbel, Heike</au><au>Fittkow, Cordula</au><au>Werner, Martin</au><au>Gitsch, Gerald</au><au>Watermann, Dirk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse</atitle><jtitle>International Urogynecology Journal</jtitle><addtitle>Int Urogynecol J Pelvic Floor Dysfunct</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>16</volume><issue>6</issue><spage>475</spage><epage>479</epage><pages>475-479</pages><issn>0937-3462</issn><eissn>1433-3023</eissn><abstract>The uterosacral ligaments are thought to contribute to pelvic support. The objective of this study was to compare the structural components of these ligaments in women with and without pelvic organ prolapse (POP). We characterized uterosacral ligaments of 25 postmenopausal women with POP and 16 controls histomorphologically and immunohistochemically by quantifying their content of collagen I, III, and smooth muscle using a computerized image analysis. In 84% the uterosacral ligaments were composed of more than 20% of smooth muscle cells. There was no difference in collagen I expression and smooth muscle cell amount between women with POP and those without. In contrast, the collagen III expression was significantly related to the presence of POP (p<0.001) rather than age or parity. Our findings suggest that the higher collagen III expression might be a typical characteristic of POP patients' connective tissue. The considerable amount of smooth muscle cells in uterosacral ligaments may provide pelvic support.</abstract><cop>England</cop><pub>Springer Nature B.V</pub><pmid>15846454</pmid><doi>10.1007/s00192-005-1294-5</doi><tpages>5</tpages></addata></record> |
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| subjects | Collagen Collagen Type I - metabolism Collagen Type III - metabolism Female Gynecology Humans Immunohistochemistry Ligaments - pathology Middle Aged Muscular system Myocytes, Smooth Muscle - pathology Pelvis - pathology Postmenopause Sacrum Uterine Prolapse - pathology Uterus Women |
| title | Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse |
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