Rapid decrease of anti-[beta]-glucan antibody as an indicator for early diagnosis of carinii pneumonitis and deep mycotic infections following immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis
Deep mycosis (aspergillus pneumonia (AsP)) and carinii pneumonitis (PCP) are complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The objective was to clarify the clinical significance of plasma titer of antibody against β-glucans (...
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| Veröffentlicht in: | Clinical rheumatology 2009-05, Vol.28 (5), p.565 |
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| creator | Yoshida, Masaharu Ishibashi, Ken-ichi Hida, Shunsuke Yoshikawa, Noriko Nakabayashi, Iwao Akashi, Masakazu Watanabe, Taeko Tomiyasu, Tomohiro Ohno, Naohito |
| description | Deep mycosis (aspergillus pneumonia (AsP)) and carinii pneumonitis (PCP) are complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The objective was to clarify the clinical significance of plasma titer of antibody against β-glucans (anti-BG antibody) as a predictor of complications such as AsP or PCP and the prognosis of patients. Enzyme-linked immunosorbent assay was used to measure the plasma titer of antibodies against β-glucans (BG) from Candida albicans in 22 healthy subjects and 52 patients with various stages of AAV. The mean plasma titer of the anti-BG antibody was 2,677±1,686 U in healthy subjects, 691±522 U in patients with untreated active vasculitis (n=14), and 547±416 U in patients soon after immunosuppressive treatment (n=24). Healthy subjects had significantly higher antibody titers than the other two groups (P |
| doi_str_mv | 10.1007/s10067-009-1096-0 |
| format | Article |
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The objective was to clarify the clinical significance of plasma titer of antibody against β-glucans (anti-BG antibody) as a predictor of complications such as AsP or PCP and the prognosis of patients. Enzyme-linked immunosorbent assay was used to measure the plasma titer of antibodies against β-glucans (BG) from Candida albicans in 22 healthy subjects and 52 patients with various stages of AAV. The mean plasma titer of the anti-BG antibody was 2,677±1,686 U in healthy subjects, 691±522 U in patients with untreated active vasculitis (n=14), and 547±416 U in patients soon after immunosuppressive treatment (n=24). Healthy subjects had significantly higher antibody titers than the other two groups (P<0.05). Repeated measurements over the clinical course of AAV revealed an increase during remission to 1,180±130 U (n=11), while there was a significant rapid decrease to 369±441 U (P<0.01) concomitantly with elevation in plasma C-reactive protein and BG levels in patients with AAV that had AsP or PCP infection. Antifungal therapy resulted in a rapid rise of anti-BG antibody titer. Experiments in mice suggested that the anti-BG antibody neutralizes BG. 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Repeated measurements over the clinical course of AAV revealed an increase during remission to 1,180±130 U (n=11), while there was a significant rapid decrease to 369±441 U (P<0.01) concomitantly with elevation in plasma C-reactive protein and BG levels in patients with AAV that had AsP or PCP infection. Antifungal therapy resulted in a rapid rise of anti-BG antibody titer. Experiments in mice suggested that the anti-BG antibody neutralizes BG. Rapid decrease of the anti-BG antibody titer may be a useful indicator for diagnosis of the presence of AsP or PCP and for estimating the prognosis of patients with these opportunistic infections during immunosuppressive treatment of AAV.[PUBLICATION ABSTRACT]</description><subject>Medical diagnosis</subject><subject>Medical treatment</subject><subject>Plasma</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNjstOwzAQRS0EEuXxAews9gabRE28RiDWiB1C1dRx0qkc23iconww_4FTwZ7FPDSPcy9jN0reKSmbeyp53QgptVBSr4U8YStVV7XQutanbCWbRopK6facXRDtpZQPrVYr9v0KETveWZMskOWh5-AzivetzfAhBjcZ8MfRNnQzByo9R9-hgRwS70tYSG7mHcLgAyEtCAMJPSKP3k5j8Jhx-VtkbOTjbEJGUyi9NRmDp4JxLnyhHziO41QwU4zJEuHB8ryzCeJczo82CjGnEHfouJlziA5oLLA_hwKIgkHItuMHIDO5RfyKnfXgyF7_1kt2-_z09vgiYgqfk6W82Ycp-bLatK2qWqVrWf3r6AeRtH-r</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Yoshida, Masaharu</creator><creator>Ishibashi, Ken-ichi</creator><creator>Hida, Shunsuke</creator><creator>Yoshikawa, Noriko</creator><creator>Nakabayashi, Iwao</creator><creator>Akashi, Masakazu</creator><creator>Watanabe, Taeko</creator><creator>Tomiyasu, Tomohiro</creator><creator>Ohno, Naohito</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20090501</creationdate><title>Rapid decrease of anti-[beta]-glucan antibody as an indicator for early diagnosis of carinii pneumonitis and deep mycotic infections following immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis</title><author>Yoshida, Masaharu ; 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| title | Rapid decrease of anti-[beta]-glucan antibody as an indicator for early diagnosis of carinii pneumonitis and deep mycotic infections following immunosuppressive therapy in antineutrophil cytoplasmic antibody-associated vasculitis |
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