Non-canonical [beta]-catenin degradation mediates reactive oxygen species-induced epidermal cell death
b-Catenin is constantly degraded through the ubiquitinproteasomal pathway. In this study, we report that a different type of b-catenin degradation is causally involved in epidermal cell death. We observed that reactive oxygen species (ROS) caused b-catenin degradation in the epidermal cells through...
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| Veröffentlicht in: | Oncogene 2011-07, Vol.30 (30), p.3336 |
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| creator | Omori, E Matsumoto, K Ninomiya-tsuji, J |
| description | b-Catenin is constantly degraded through the ubiquitinproteasomal pathway. In this study, we report that a different type of b-catenin degradation is causally involved in epidermal cell death. We observed that reactive oxygen species (ROS) caused b-catenin degradation in the epidermal cells through a caspase-dependent mechanism, which results in disruption of cell adhesion. Disruption of cell adhesion increased ROS and activated caspases.Upregulation of the intact b-catenin blocked ROS accumulation and caspase activation. These results indicate that a feed-forward loop consisting of ROS, caspases activation and b-catenin degradation induces epidermal cell death. [PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1038/onc.2011.49 |
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In this study, we report that a different type of b-catenin degradation is causally involved in epidermal cell death. We observed that reactive oxygen species (ROS) caused b-catenin degradation in the epidermal cells through a caspase-dependent mechanism, which results in disruption of cell adhesion. Disruption of cell adhesion increased ROS and activated caspases.Upregulation of the intact b-catenin blocked ROS accumulation and caspase activation. These results indicate that a feed-forward loop consisting of ROS, caspases activation and b-catenin degradation induces epidermal cell death. 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| ispartof | Oncogene, 2011-07, Vol.30 (30), p.3336 |
| issn | 0950-9232 1476-5594 |
| language | eng |
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| source | Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Apoptosis Cell adhesion & migration Cell death Enzymes Oncology |
| title | Non-canonical [beta]-catenin degradation mediates reactive oxygen species-induced epidermal cell death |
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