PR-104 plus sorafenib in patients with advanced hepatocellular carcinoma

Purpose PR-104 is activated by reductases under hypoxia or by aldo–keto reductase 1C3 (AKR1C3) to form cytotoxic nitrogen mustards. Hepatocellular carcinoma (HCC) displays extensive hypoxia and expresses AKR1C3. This study evaluated the safety and efficacy of PR-104 plus sorafenib in HCC. Methods Pa...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2011-08, Vol.68 (2), p.539-545
Hauptverfasser:	Abou-Alfa, Ghassan K., Chan, Stephan L., Lin, Chia-Chi, Chiorean, E. Gabriela, Holcombe, Randall F., Mulcahy, Mary F., Carter, William D., Patel, Kashyap, Wilson, William R., Melink, Teresa J., Gutheil, John C., Tsao, Chao-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - blood Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - blood Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asian Continental Ancestry Group Benzenesulfonates - administration & dosage Benzenesulfonates - adverse effects Benzenesulfonates - therapeutic use Biological and medical sciences Cancer Research Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - drug therapy Clinical Trial Report Cohort Studies Female Gastroenterology. Liver. Pancreas. Abdomen Half-Life Humans Liver Cirrhosis - complications Liver Neoplasms - drug therapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Staging Niacinamide - analogs & derivatives Nitrogen Mustard Compounds - administration & dosage Nitrogen Mustard Compounds - adverse effects Nitrogen Mustard Compounds - blood Nitrogen Mustard Compounds - therapeutic use Oncology Pharmacology. Drug treatments Pharmacology/Toxicology Phenylurea Compounds Prodrugs - administration & dosage Prodrugs - adverse effects Prodrugs - therapeutic use Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Pyridines - administration & dosage Pyridines - adverse effects Pyridines - therapeutic use Tumors
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