Low risk stage I endometrial carcinoma: prognostic factors and outcomes
The aim of the study is to evaluate clinical features of patients with low-risk stage I endometrium cancer, who received adjuvant therapy or followed with observation only and to analyse the effects of known prognostic factors in this group of patients. A total of 246 patients (median age: 53, range...
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| Veröffentlicht in: | Indian journal of cancer 2011-04, Vol.48 (2), p.204 |
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| description | The aim of the study is to evaluate clinical features of patients with low-risk stage I endometrium cancer, who received adjuvant therapy or followed with observation only and to analyse the effects of known prognostic factors in this group of patients.
A total of 246 patients (median age: 53, range: 31-77) with low-risk stage I endometrial cancer, who were just followed postoperatively (156 patients) or received adjuvant radiotherapy (90 patients) between 1996 and 2007 were reviewed retrospectively.
Local recurrence was detected in four patients, distant metastasis occurred in seven patients, and two patients had both local recurrence and distant metastasis. The 83.3% of recurrences were on the vaginal stump. Five- and ten-year local control (LC) and overall survival (OS) rates are 97.6%, 97.6% and 96.4%, 93.5% in the observation and adjuvant therapy groups, respectively, whereas distant control rates are 96.7% and 96.3%. In multivariate analysis, only age and lymphovascular invasion (LVI) were found to affect OS and disease-free survival (DFS).
LC and OS rates are high in the low-risk group of patients; however, current adjuvant therapies did not improve the outcomes. Age over 60 years and the presence of LVI have negative effects on outcomes in this group of patients. |
| doi_str_mv | 10.4103/0019-509X.82895 |
| format | Article |
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A total of 246 patients (median age: 53, range: 31-77) with low-risk stage I endometrial cancer, who were just followed postoperatively (156 patients) or received adjuvant radiotherapy (90 patients) between 1996 and 2007 were reviewed retrospectively.
Local recurrence was detected in four patients, distant metastasis occurred in seven patients, and two patients had both local recurrence and distant metastasis. The 83.3% of recurrences were on the vaginal stump. Five- and ten-year local control (LC) and overall survival (OS) rates are 97.6%, 97.6% and 96.4%, 93.5% in the observation and adjuvant therapy groups, respectively, whereas distant control rates are 96.7% and 96.3%. In multivariate analysis, only age and lymphovascular invasion (LVI) were found to affect OS and disease-free survival (DFS).
LC and OS rates are high in the low-risk group of patients; however, current adjuvant therapies did not improve the outcomes. Age over 60 years and the presence of LVI have negative effects on outcomes in this group of patients.</description><identifier>ISSN: 0019-509X</identifier><identifier>EISSN: 1998-4774</identifier><identifier>DOI: 10.4103/0019-509X.82895</identifier><identifier>PMID: 21768667</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Adenocarcinoma - radiotherapy ; Adenocarcinoma - secondary ; Adenocarcinoma - surgery ; Adjuvant treatment ; Adult ; Aged ; Cancer ; Carcinoma, Papillary - radiotherapy ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - surgery ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Care and treatment ; Development and progression ; Endometrial cancer ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - radiotherapy ; Endometrial Neoplasms - surgery ; Female ; Follow-Up Studies ; Health aspects ; Humans ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - radiotherapy ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Prognosis ; Radiotherapy ; Radiotherapy, Adjuvant ; Retrospective Studies ; Risk Factors ; Survival Rate</subject><ispartof>Indian journal of cancer, 2011-04, Vol.48 (2), p.204</ispartof><rights>COPYRIGHT 2011 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-e1819b222e5979c9670ffbf492c3856114adc9828f38a20bb1f8cbfb5a0cd80b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21768667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoney, A</creatorcontrib><creatorcontrib>Yildirim, C</creatorcontrib><creatorcontrib>Bati, Y</creatorcontrib><creatorcontrib>Unsal, M</creatorcontrib><title>Low risk stage I endometrial carcinoma: prognostic factors and outcomes</title><title>Indian journal of cancer</title><addtitle>Indian J Cancer</addtitle><description>The aim of the study is to evaluate clinical features of patients with low-risk stage I endometrium cancer, who received adjuvant therapy or followed with observation only and to analyse the effects of known prognostic factors in this group of patients.
A total of 246 patients (median age: 53, range: 31-77) with low-risk stage I endometrial cancer, who were just followed postoperatively (156 patients) or received adjuvant radiotherapy (90 patients) between 1996 and 2007 were reviewed retrospectively.
Local recurrence was detected in four patients, distant metastasis occurred in seven patients, and two patients had both local recurrence and distant metastasis. The 83.3% of recurrences were on the vaginal stump. Five- and ten-year local control (LC) and overall survival (OS) rates are 97.6%, 97.6% and 96.4%, 93.5% in the observation and adjuvant therapy groups, respectively, whereas distant control rates are 96.7% and 96.3%. In multivariate analysis, only age and lymphovascular invasion (LVI) were found to affect OS and disease-free survival (DFS).
LC and OS rates are high in the low-risk group of patients; however, current adjuvant therapies did not improve the outcomes. Age over 60 years and the presence of LVI have negative effects on outcomes in this group of patients.</description><subject>Adenocarcinoma - radiotherapy</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - surgery</subject><subject>Adjuvant treatment</subject><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Carcinoma, Papillary - radiotherapy</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Care and treatment</subject><subject>Development and progression</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - radiotherapy</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Radiotherapy</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><issn>0019-509X</issn><issn>1998-4774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc1LBCEYhyWK2j7O3UIKus2mzpd2W5bagoUuBd3EcXTXmtFSh-i_z21rKVg8CPr8fH3fB4BTjMYFRvkVQphlJWLPY0ooK3fACDNGs6Kui10w2twegMMQXhAiOSnoPjgguK5oVdUjMJu7D-hNeIUhioWC91DZ1vUqeiM6KIWXxrpeXMM37xbWhWgk1EJG5wMUtoVuiDLh4RjsadEFdfKzH4Gn25vH6V02f5jdTyfzTBYli5nCFLOGEKJKVjPJqhpp3eiCEZnTssK4EK1kqRedU0FQ02BNZaObUiDZUtTkR-B8_W76z_ugQuQvbvA2leS0pjgnuKwSdLGGFqJT3FjtoheyN0HyCakwrUtWkURlW6iFssqLzlmlTTr-x4-38Gm1qjdya-DyT2CpRBeXwXVDNM6G_-DVGpTeheCV5m_e9MJ_coz4yjNfmeQrk_zbc0qc_YxhaHrVbvhfsfkX5ISf0g</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Yoney, A</creator><creator>Yildirim, C</creator><creator>Bati, Y</creator><creator>Unsal, M</creator><general>Medknow Publications and Media Pvt. 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radiotherapy</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - surgery</topic><topic>Adjuvant treatment</topic><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Carcinoma, Papillary - radiotherapy</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Care and treatment</topic><topic>Development and progression</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - radiotherapy</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - radiotherapy</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Radiotherapy</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoney, A</creatorcontrib><creatorcontrib>Yildirim, C</creatorcontrib><creatorcontrib>Bati, Y</creatorcontrib><creatorcontrib>Unsal, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Indian journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoney, A</au><au>Yildirim, C</au><au>Bati, Y</au><au>Unsal, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low risk stage I endometrial carcinoma: prognostic factors and outcomes</atitle><jtitle>Indian journal of cancer</jtitle><addtitle>Indian J Cancer</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>48</volume><issue>2</issue><spage>204</spage><pages>204-</pages><issn>0019-509X</issn><eissn>1998-4774</eissn><abstract>The aim of the study is to evaluate clinical features of patients with low-risk stage I endometrium cancer, who received adjuvant therapy or followed with observation only and to analyse the effects of known prognostic factors in this group of patients.
A total of 246 patients (median age: 53, range: 31-77) with low-risk stage I endometrial cancer, who were just followed postoperatively (156 patients) or received adjuvant radiotherapy (90 patients) between 1996 and 2007 were reviewed retrospectively.
Local recurrence was detected in four patients, distant metastasis occurred in seven patients, and two patients had both local recurrence and distant metastasis. The 83.3% of recurrences were on the vaginal stump. Five- and ten-year local control (LC) and overall survival (OS) rates are 97.6%, 97.6% and 96.4%, 93.5% in the observation and adjuvant therapy groups, respectively, whereas distant control rates are 96.7% and 96.3%. In multivariate analysis, only age and lymphovascular invasion (LVI) were found to affect OS and disease-free survival (DFS).
LC and OS rates are high in the low-risk group of patients; however, current adjuvant therapies did not improve the outcomes. Age over 60 years and the presence of LVI have negative effects on outcomes in this group of patients.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>21768667</pmid><doi>10.4103/0019-509X.82895</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-509X |
| ispartof | Indian journal of cancer, 2011-04, Vol.48 (2), p.204 |
| issn | 0019-509X 1998-4774 |
| language | eng |
| recordid | cdi_proquest_journals_878132156 |
| source | MEDLINE; Medknow Open Access Medical Journals; Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenocarcinoma - radiotherapy Adenocarcinoma - secondary Adenocarcinoma - surgery Adjuvant treatment Adult Aged Cancer Carcinoma, Papillary - radiotherapy Carcinoma, Papillary - secondary Carcinoma, Papillary - surgery Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Care and treatment Development and progression Endometrial cancer Endometrial Neoplasms - pathology Endometrial Neoplasms - radiotherapy Endometrial Neoplasms - surgery Female Follow-Up Studies Health aspects Humans Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Neoplasm Recurrence, Local - surgery Neoplasm Staging Prognosis Radiotherapy Radiotherapy, Adjuvant Retrospective Studies Risk Factors Survival Rate |
| title | Low risk stage I endometrial carcinoma: prognostic factors and outcomes |
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