The JAK2/STAT3 signaling pathway is required for growth of CD44^sup +^CD24^sup -^ stem cell-like breast cancer cells in human tumors

Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in progression. We previously characterized 2 cell populations in human breast tumors with distinct properties: CD44+CD24- cells that have stem c...

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Veröffentlicht in:	The Journal of clinical investigation 2011-07, Vol.121 (7), p.2723
Hauptverfasser:	Marotta, Lauren L C, Almendro, Vanessa, Marusyk, Andriy, Shipitsin, Michail, Schemme, Janina, Walker, Sarah R, Bloushtain-Qimron, Noga, Kim, Jessica J, Choudhury, Sibgat A, Maruyama, Reo, Wu, Zhenhua, Gönen, Mithat, Mulvey, Laura A, Bessarabova, Marina O, Huh, Sung Jin, Silver, Serena J, Kim, So Young, Park, So Yeon, Lee, Hee Eun, Anderson, Karen S, Richardson, Andrea L, Nikolskaya, Tatiana, Nikolsky, Yuri, Liu, X Shirley, Root, David E, Hahn, William C, Frank, David A, Polyak, Kornelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Breast cancer DNA methylation Flow cytometry Gene expression Kinases Medical prognosis Pleural effusion Stem cells Tumors
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