Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound
A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The material is a high-temperature hydrogel matrix (gellan gum) combined with different sizes of aluminum oxide particles and other chemicals. The u...
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| Veröffentlicht in: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2011-07, Vol.58 (7), p.1397-1405 |
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| container_title | IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
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| creator | King, R. L. Yunbo Liu Maruvada, S. Herman, B. A. Wear, K. A. Harris, G. R. |
| description | A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The material is a high-temperature hydrogel matrix (gellan gum) combined with different sizes of aluminum oxide particles and other chemicals. The ultrasonic properties (attenuation coefficient, speed of sound, acoustical impedance, and the thermal conductivity and diffusivity) were characterized as a function of temperature from 20 to 70°C. The backscatter coefficient and nonlinearity parameter B/A were measured at room temperature. Importantly, the attenuation coefficient has essentially linear frequency dependence, as is the case for most mammalian tissues at 37°C. The mean value is 0.64f 0.95 dB·cm -1 at 20°C, based on measurements from 2 to 8 MHz. Most of the other relevant physical parameters are also close to the reported values, although backscatter signals are low compared with typical human soft tissues. Repeatable and consistent temperature elevations of 40°C were produced under 20-s HIFU exposures in the TMM. This TMM is appropriate for developing standardized dosimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU devices. |
| doi_str_mv | 10.1109/TUFFC.2011.1959 |
| format | Article |
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L. ; Yunbo Liu ; Maruvada, S. ; Herman, B. A. ; Wear, K. A. ; Harris, G. R.</creator><creatorcontrib>King, R. L. ; Yunbo Liu ; Maruvada, S. ; Herman, B. A. ; Wear, K. A. ; Harris, G. R.</creatorcontrib><description>A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The material is a high-temperature hydrogel matrix (gellan gum) combined with different sizes of aluminum oxide particles and other chemicals. The ultrasonic properties (attenuation coefficient, speed of sound, acoustical impedance, and the thermal conductivity and diffusivity) were characterized as a function of temperature from 20 to 70°C. The backscatter coefficient and nonlinearity parameter B/A were measured at room temperature. Importantly, the attenuation coefficient has essentially linear frequency dependence, as is the case for most mammalian tissues at 37°C. The mean value is 0.64f 0.95 dB·cm -1 at 20°C, based on measurements from 2 to 8 MHz. Most of the other relevant physical parameters are also close to the reported values, although backscatter signals are low compared with typical human soft tissues. Repeatable and consistent temperature elevations of 40°C were produced under 20-s HIFU exposures in the TMM. This TMM is appropriate for developing standardized dosimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU devices.</description><identifier>ISSN: 0885-3010</identifier><identifier>EISSN: 1525-8955</identifier><identifier>DOI: 10.1109/TUFFC.2011.1959</identifier><identifier>PMID: 21768024</identifier><identifier>CODEN: ITUCER</identifier><language>eng</language><publisher>New York, NY: IEEE</publisher><subject>Acoustics ; Aluminum Oxide - chemistry ; Attenuation ; Backscatter ; Biological and medical sciences ; Biomimetic Materials - chemistry ; High-Intensity Focused Ultrasound Ablation - instrumentation ; High-Intensity Focused Ultrasound Ablation - standards ; Hot Temperature ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Materials ; Medical sciences ; Miscellaneous. Technology ; Nonlinear Dynamics ; Phantoms, Imaging ; Polysaccharides, Bacterial - chemistry ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Reproducibility of Results ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments. Material. Instrumentation ; Temperature measurement ; Ultrasonic imaging ; Ultrasonic investigative techniques ; Ultrasonic variables measurement</subject><ispartof>IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2011-07, Vol.58 (7), p.1397-1405</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. 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L.</creatorcontrib><creatorcontrib>Yunbo Liu</creatorcontrib><creatorcontrib>Maruvada, S.</creatorcontrib><creatorcontrib>Herman, B. A.</creatorcontrib><creatorcontrib>Wear, K. A.</creatorcontrib><creatorcontrib>Harris, G. R.</creatorcontrib><title>Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound</title><title>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</title><addtitle>T-UFFC</addtitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><description>A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The material is a high-temperature hydrogel matrix (gellan gum) combined with different sizes of aluminum oxide particles and other chemicals. 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This TMM is appropriate for developing standardized dosimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU devices.</description><subject>Acoustics</subject><subject>Aluminum Oxide - chemistry</subject><subject>Attenuation</subject><subject>Backscatter</subject><subject>Biological and medical sciences</subject><subject>Biomimetic Materials - chemistry</subject><subject>High-Intensity Focused Ultrasound Ablation - instrumentation</subject><subject>High-Intensity Focused Ultrasound Ablation - standards</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Materials</subject><subject>Medical sciences</subject><subject>Miscellaneous. Technology</subject><subject>Nonlinear Dynamics</subject><subject>Phantoms, Imaging</subject><subject>Polysaccharides, Bacterial - chemistry</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Reproducibility of Results</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><subject>Temperature measurement</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonic variables measurement</subject><issn>0885-3010</issn><issn>1525-8955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAQQC3UqmyhZw5IyELqMYvHjhP7WC1dWgmJC5wjxxmzhsRZbAcJfn2z3S09jEaaefOhR8gZsCUA01f3D-v1askZwBK01EdkAZLLQmkpP5EFU0oWggE7Jl9TemIMylLzL-SYQ10pxssFwWt8xX7cDhgyNaGjdmOisRmjfzfZj4GOjhqafUoTFoMfvH324ZEOZoeYnrox0o1_3BQ-ZAzJ57e5ZKeEHZ36HE0ap9Cdks_O9Am_HfIJeVj_vF_9Km7vbn6vftwWVpSQC8OURoeu4q3u0FS2Zk6WqmLYAeiWCwDDZSvn97U0IJySNVdlybmquOxacUIu93u3cXyZMOXmaZximE82qq6VECDkDF3tIRvHlCK6Zhv9YOJbA6zZWW3-Wm12Vpud1Xni4rB2agfsPvh_Gmfg-wEwyZreRROsT_-5UmjOAWbufM95RPxoSy2FnuMPpEiJIA</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>King, R. 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R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-a089efef62b9dea6c70f54860ed119b2311a25b521795a13f8572844228625db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acoustics</topic><topic>Aluminum Oxide - chemistry</topic><topic>Attenuation</topic><topic>Backscatter</topic><topic>Biological and medical sciences</topic><topic>Biomimetic Materials - chemistry</topic><topic>High-Intensity Focused Ultrasound Ablation - instrumentation</topic><topic>High-Intensity Focused Ultrasound Ablation - standards</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Materials</topic><topic>Medical sciences</topic><topic>Miscellaneous. Technology</topic><topic>Nonlinear Dynamics</topic><topic>Phantoms, Imaging</topic><topic>Polysaccharides, Bacterial - chemistry</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Reproducibility of Results</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><topic>Temperature measurement</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonic variables measurement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, R. L.</creatorcontrib><creatorcontrib>Yunbo Liu</creatorcontrib><creatorcontrib>Maruvada, S.</creatorcontrib><creatorcontrib>Herman, B. A.</creatorcontrib><creatorcontrib>Wear, K. A.</creatorcontrib><creatorcontrib>Harris, G. R.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>King, R. L.</au><au>Yunbo Liu</au><au>Maruvada, S.</au><au>Herman, B. A.</au><au>Wear, K. A.</au><au>Harris, G. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound</atitle><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle><stitle>T-UFFC</stitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>58</volume><issue>7</issue><spage>1397</spage><epage>1405</epage><pages>1397-1405</pages><issn>0885-3010</issn><eissn>1525-8955</eissn><coden>ITUCER</coden><abstract>A tissue-mimicking material (TMM) for the acoustic and thermal characterization of high-intensity focused ultrasound (HIFU) devices has been developed. The material is a high-temperature hydrogel matrix (gellan gum) combined with different sizes of aluminum oxide particles and other chemicals. The ultrasonic properties (attenuation coefficient, speed of sound, acoustical impedance, and the thermal conductivity and diffusivity) were characterized as a function of temperature from 20 to 70°C. The backscatter coefficient and nonlinearity parameter B/A were measured at room temperature. Importantly, the attenuation coefficient has essentially linear frequency dependence, as is the case for most mammalian tissues at 37°C. The mean value is 0.64f 0.95 dB·cm -1 at 20°C, based on measurements from 2 to 8 MHz. Most of the other relevant physical parameters are also close to the reported values, although backscatter signals are low compared with typical human soft tissues. Repeatable and consistent temperature elevations of 40°C were produced under 20-s HIFU exposures in the TMM. This TMM is appropriate for developing standardized dosimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU devices.</abstract><cop>New York, NY</cop><pub>IEEE</pub><pmid>21768024</pmid><doi>10.1109/TUFFC.2011.1959</doi><tpages>9</tpages></addata></record> |
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| subjects | Acoustics Aluminum Oxide - chemistry Attenuation Backscatter Biological and medical sciences Biomimetic Materials - chemistry High-Intensity Focused Ultrasound Ablation - instrumentation High-Intensity Focused Ultrasound Ablation - standards Hot Temperature Humans Investigative techniques, diagnostic techniques (general aspects) Materials Medical sciences Miscellaneous. Technology Nonlinear Dynamics Phantoms, Imaging Polysaccharides, Bacterial - chemistry Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Reproducibility of Results Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments. Material. Instrumentation Temperature measurement Ultrasonic imaging Ultrasonic investigative techniques Ultrasonic variables measurement |
| title | Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound |
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