Eosinophil Granule Protein Localization in Eosinophilic Endomyocardial Disease
In this case report, eosinophilic endomyocardial disease was diagnosed in a patient on the basis of immunohistochemical evidence of eosinophil granule protein deposition in the heart, even in the absence of eosinophilic infiltration on cardiac biopsy. To the Editor: A 70-year-old man with chronic re...
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| Veröffentlicht in: | The New England journal of medicine 2011-07, Vol.365 (2), p.187-188 |
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| container_title | The New England journal of medicine |
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| creator | Wright, Benjamin L Leiferman, Kristin M Gleich, Gerald J |
| description | In this case report, eosinophilic endomyocardial disease was diagnosed in a patient on the basis of immunohistochemical evidence of eosinophil granule protein deposition in the heart, even in the absence of eosinophilic infiltration on cardiac biopsy.
To the Editor:
A 70-year-old man with chronic renal disease, splenomegaly, and eosinophilia presented with transient weakness in the left arm, visual disturbances, disequilibrium, and anomia. Magnetic resonance imaging of the brain showed findings consistent with numerous, small embolic strokes. Four echocardiograms, including a transesophageal echocardiogram, did not reveal abnormalities. Therapeutic trials of glucocorticoids and imatinib were unsuccessful at reducing the numbers of peripheral-blood eosinophils. To investigate the possibility that the emboli were the sequelae of eosinophilic endomyocardial disease, the patient underwent a biopsy of his right ventricle and intraventricular septum. Staining of the myocardium with hematoxylin and eosin did . . . |
| doi_str_mv | 10.1056/NEJMc1103005 |
| format | Article |
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To the Editor:
A 70-year-old man with chronic renal disease, splenomegaly, and eosinophilia presented with transient weakness in the left arm, visual disturbances, disequilibrium, and anomia. Magnetic resonance imaging of the brain showed findings consistent with numerous, small embolic strokes. Four echocardiograms, including a transesophageal echocardiogram, did not reveal abnormalities. Therapeutic trials of glucocorticoids and imatinib were unsuccessful at reducing the numbers of peripheral-blood eosinophils. To investigate the possibility that the emboli were the sequelae of eosinophilic endomyocardial disease, the patient underwent a biopsy of his right ventricle and intraventricular septum. Staining of the myocardium with hematoxylin and eosin did . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc1103005</identifier><identifier>PMID: 21751935</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aged ; Antibodies ; Biopsy ; Blood Proteins - analysis ; Blood Proteins - immunology ; Endocardium - pathology ; Endomyocardial Fibrosis - etiology ; Endomyocardial Fibrosis - pathology ; Eosinophil Major Basic Protein ; Humans ; Hypereosinophilic Syndrome - complications ; Hypereosinophilic Syndrome - diagnosis ; Leukocytes (eosinophilic) ; Localization ; Male ; Proteins ; Proteoglycans - analysis ; Proteoglycans - immunology ; Renal Insufficiency, Chronic - complications</subject><ispartof>The New England journal of medicine, 2011-07, Vol.365 (2), p.187-188</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-195773bb87753dde9d5f9ea10822226bfde945d7ff0b36b6e90564ebe737b54d3</citedby><cites>FETCH-LOGICAL-c418t-195773bb87753dde9d5f9ea10822226bfde945d7ff0b36b6e90564ebe737b54d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc1103005$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMc1103005$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21751935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, Benjamin L</creatorcontrib><creatorcontrib>Leiferman, Kristin M</creatorcontrib><creatorcontrib>Gleich, Gerald J</creatorcontrib><title>Eosinophil Granule Protein Localization in Eosinophilic Endomyocardial Disease</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this case report, eosinophilic endomyocardial disease was diagnosed in a patient on the basis of immunohistochemical evidence of eosinophil granule protein deposition in the heart, even in the absence of eosinophilic infiltration on cardiac biopsy.
To the Editor:
A 70-year-old man with chronic renal disease, splenomegaly, and eosinophilia presented with transient weakness in the left arm, visual disturbances, disequilibrium, and anomia. Magnetic resonance imaging of the brain showed findings consistent with numerous, small embolic strokes. Four echocardiograms, including a transesophageal echocardiogram, did not reveal abnormalities. Therapeutic trials of glucocorticoids and imatinib were unsuccessful at reducing the numbers of peripheral-blood eosinophils. To investigate the possibility that the emboli were the sequelae of eosinophilic endomyocardial disease, the patient underwent a biopsy of his right ventricle and intraventricular septum. Staining of the myocardium with hematoxylin and eosin did . . .</description><subject>Aged</subject><subject>Antibodies</subject><subject>Biopsy</subject><subject>Blood Proteins - analysis</subject><subject>Blood Proteins - immunology</subject><subject>Endocardium - pathology</subject><subject>Endomyocardial Fibrosis - etiology</subject><subject>Endomyocardial Fibrosis - pathology</subject><subject>Eosinophil Major Basic Protein</subject><subject>Humans</subject><subject>Hypereosinophilic Syndrome - complications</subject><subject>Hypereosinophilic Syndrome - diagnosis</subject><subject>Leukocytes (eosinophilic)</subject><subject>Localization</subject><subject>Male</subject><subject>Proteins</subject><subject>Proteoglycans - analysis</subject><subject>Proteoglycans - immunology</subject><subject>Renal Insufficiency, Chronic - complications</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkD1PwzAQhi0EouVjY0YRYiRg13Ycj6iEAiqFAWbLjh3hKrGLnQzl12PU8jFwy-lOj97TPQCcIHiJIC2uFtXDY40QxBDSHTBGFOOcEFjsgjGEkzInjOMROIhxCVMhwvfBaIIYRRzTMVhUPlrnV2-2zWZBuqE12XPwvbEum_tatvZD9ta7LM2_qK2zymnfrRMRtJVtdmOjkdEcgb1GttEcb_sheL2tXqZ3-fxpdj-9nuc1QWWfI04Zw0qVjFGsteGaNtxIBMtJqkI1aUWoZk0DFS5UYXj6lBhlGGaKEo0PwdkmdxX8-2BiL5Z-CC6dFCUreHJBYIIuNlAdfIzBNGIVbCfDWiAovtyJv-4SfrrNHFRn9A_8LSsB5xug66JwZtn9n_MJyOR0Sw</recordid><startdate>20110714</startdate><enddate>20110714</enddate><creator>Wright, Benjamin L</creator><creator>Leiferman, Kristin M</creator><creator>Gleich, Gerald J</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20110714</creationdate><title>Eosinophil Granule Protein Localization in Eosinophilic Endomyocardial Disease</title><author>Wright, Benjamin L ; Leiferman, Kristin M ; Gleich, Gerald J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-195773bb87753dde9d5f9ea10822226bfde945d7ff0b36b6e90564ebe737b54d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Antibodies</topic><topic>Biopsy</topic><topic>Blood Proteins - analysis</topic><topic>Blood Proteins - immunology</topic><topic>Endocardium - pathology</topic><topic>Endomyocardial Fibrosis - etiology</topic><topic>Endomyocardial Fibrosis - pathology</topic><topic>Eosinophil Major Basic Protein</topic><topic>Humans</topic><topic>Hypereosinophilic Syndrome - complications</topic><topic>Hypereosinophilic Syndrome - diagnosis</topic><topic>Leukocytes (eosinophilic)</topic><topic>Localization</topic><topic>Male</topic><topic>Proteins</topic><topic>Proteoglycans - analysis</topic><topic>Proteoglycans - immunology</topic><topic>Renal Insufficiency, Chronic - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, Benjamin L</creatorcontrib><creatorcontrib>Leiferman, Kristin M</creatorcontrib><creatorcontrib>Gleich, Gerald J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, Benjamin L</au><au>Leiferman, Kristin M</au><au>Gleich, Gerald J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eosinophil Granule Protein Localization in Eosinophilic Endomyocardial Disease</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2011-07-14</date><risdate>2011</risdate><volume>365</volume><issue>2</issue><spage>187</spage><epage>188</epage><pages>187-188</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>In this case report, eosinophilic endomyocardial disease was diagnosed in a patient on the basis of immunohistochemical evidence of eosinophil granule protein deposition in the heart, even in the absence of eosinophilic infiltration on cardiac biopsy.
To the Editor:
A 70-year-old man with chronic renal disease, splenomegaly, and eosinophilia presented with transient weakness in the left arm, visual disturbances, disequilibrium, and anomia. Magnetic resonance imaging of the brain showed findings consistent with numerous, small embolic strokes. Four echocardiograms, including a transesophageal echocardiogram, did not reveal abnormalities. Therapeutic trials of glucocorticoids and imatinib were unsuccessful at reducing the numbers of peripheral-blood eosinophils. To investigate the possibility that the emboli were the sequelae of eosinophilic endomyocardial disease, the patient underwent a biopsy of his right ventricle and intraventricular septum. Staining of the myocardium with hematoxylin and eosin did . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>21751935</pmid><doi>10.1056/NEJMc1103005</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Aged Antibodies Biopsy Blood Proteins - analysis Blood Proteins - immunology Endocardium - pathology Endomyocardial Fibrosis - etiology Endomyocardial Fibrosis - pathology Eosinophil Major Basic Protein Humans Hypereosinophilic Syndrome - complications Hypereosinophilic Syndrome - diagnosis Leukocytes (eosinophilic) Localization Male Proteins Proteoglycans - analysis Proteoglycans - immunology Renal Insufficiency, Chronic - complications |
| title | Eosinophil Granule Protein Localization in Eosinophilic Endomyocardial Disease |
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