Levosimendan attenuates pulmonary vascular remodeling

Purpose The calcium-sensitizing drug levosimendan increases myocardial contractility and, by activating K + -channels, dilates pulmonary vessels. In the acute setting, levosimendan is clinically used to treat right heart failure in pulmonary hypertension. As K + -channel activation elicits several b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Intensive care medicine 2011-08, Vol.37 (8), p.1368-1377
Hauptverfasser:	Revermann, M., Schloss, M., Mieth, A., Babelova, A., Schröder, K., Neofitidou, S., Buerkl, J., Kirschning, T., Schermuly, R. T., Hofstetter, C., Brandes, R. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Airway Remodeling - drug effects Analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Animals Apoptosis Biological and medical sciences Cardiotonic Agents - administration & dosage Cardiotonic Agents - pharmacology Critical Care Medicine Cyclic guanylic acid Disease Models, Animal Drug dosages Emergency Medicine Endothelium Experimental Germany Glibenclamide Glyburide - administration & dosage Glyburide - pharmacology Heart Hydrazones - administration & dosage Hydrazones - pharmacology Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Intensive Intensive care medicine Laboratory animals Medical sciences Medicine Medicine & Public Health Muscle proteins Myocardial Contraction - drug effects Nicorandil - administration & dosage Nicorandil - pharmacology Pain Medicine Pediatrics Platelet-derived growth factor Pneumology Pneumology/Respiratory System Potassium Potassium channels Potassium Channels - drug effects Pulmonary Circulation - drug effects Pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Pyridazines - administration & dosage Pyridazines - pharmacology Rats Rats, Sprague-Dawley Smooth muscle Thrombosis Tumor necrosis factor-TNF Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!