High-Sensitivity Analysis of Six Synthetic Musks by Ultra-Performance Liquid Chromatography–Atmospheric Pressure Photoionization–Tandem Mass Spectrometry
The occurrence and potential toxicity of synthetic musks in environmental media have aroused concerns for the impacts of these chemicals on ecosystems and human health. Here, we present the first method using ultra-performance liquid chromatography–atmospheric pressure photoionization–tandem mass sp...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2011-06, Vol.83 (12), p.4955-4961 |
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| creator | Lung, Shih-Chun Candice Liu, Chun-Hu |
| description | The occurrence and potential toxicity of synthetic musks in environmental media have aroused concerns for the impacts of these chemicals on ecosystems and human health. Here, we present the first method using ultra-performance liquid chromatography–atmospheric pressure photoionization–tandem mass spectrometry (UPLC-APPI-MS/MS) for analysis of the six most important synthetic musks. Analysis was performed on an API 3000 triple quadrupole equipped with a PhotoSpray APPI source. Two pairs of precursor/product ions are presented that are essential for confirmation. Chromatographic separation is completed in 7 min in the positive mode and 5.1 min in the negative mode. Furthermore, three dopant solutions (0.5% anisole in toluene, 0.5% 2,4-difluoroanisole (DFA) in bromobenzene, and 0.5% DFA in chlorobenzene) are compared in terms of sensitivity, linearity, precision, and accuracy. The best sensitivity is associated with 0.5% anisole in toluene as the dopant; all LODs are below 6 pg. The linear range is 5 to 500 ppb with fairly good precision and accuracy. This analytical method has also proven its applicability by analyzing real air samples. In summary, we present a fast, sensitive, and reliable UPLC-APPI-MS/MS method for six important synthetic musks; it can be readily applied to environmental studies. |
| doi_str_mv | 10.1021/ac2006872 |
| format | Article |
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Here, we present the first method using ultra-performance liquid chromatography–atmospheric pressure photoionization–tandem mass spectrometry (UPLC-APPI-MS/MS) for analysis of the six most important synthetic musks. Analysis was performed on an API 3000 triple quadrupole equipped with a PhotoSpray APPI source. Two pairs of precursor/product ions are presented that are essential for confirmation. Chromatographic separation is completed in 7 min in the positive mode and 5.1 min in the negative mode. Furthermore, three dopant solutions (0.5% anisole in toluene, 0.5% 2,4-difluoroanisole (DFA) in bromobenzene, and 0.5% DFA in chlorobenzene) are compared in terms of sensitivity, linearity, precision, and accuracy. The best sensitivity is associated with 0.5% anisole in toluene as the dopant; all LODs are below 6 pg. The linear range is 5 to 500 ppb with fairly good precision and accuracy. This analytical method has also proven its applicability by analyzing real air samples. 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Chem</addtitle><description>The occurrence and potential toxicity of synthetic musks in environmental media have aroused concerns for the impacts of these chemicals on ecosystems and human health. Here, we present the first method using ultra-performance liquid chromatography–atmospheric pressure photoionization–tandem mass spectrometry (UPLC-APPI-MS/MS) for analysis of the six most important synthetic musks. Analysis was performed on an API 3000 triple quadrupole equipped with a PhotoSpray APPI source. Two pairs of precursor/product ions are presented that are essential for confirmation. Chromatographic separation is completed in 7 min in the positive mode and 5.1 min in the negative mode. Furthermore, three dopant solutions (0.5% anisole in toluene, 0.5% 2,4-difluoroanisole (DFA) in bromobenzene, and 0.5% DFA in chlorobenzene) are compared in terms of sensitivity, linearity, precision, and accuracy. The best sensitivity is associated with 0.5% anisole in toluene as the dopant; all LODs are below 6 pg. The linear range is 5 to 500 ppb with fairly good precision and accuracy. This analytical method has also proven its applicability by analyzing real air samples. In summary, we present a fast, sensitive, and reliable UPLC-APPI-MS/MS method for six important synthetic musks; it can be readily applied to environmental studies.</description><subject>Accuracy</subject><subject>Analytical chemistry</subject><subject>Applied sciences</subject><subject>Atmospheric pressure</subject><subject>Benzopyrans - analysis</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Exact sciences and technology</subject><subject>Global environmental pollution</subject><subject>Indans - analysis</subject><subject>Mass spectrometry</subject><subject>Other chromatographic methods</subject><subject>Pollution</subject><subject>Polycyclic Compounds - analysis</subject><subject>Spectrometric and optical methods</subject><subject>Tandem Mass Spectrometry - instrumentation</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Tetrahydronaphthalenes - analysis</subject><subject>Toxicity</subject><subject>Xylenes - analysis</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0ctO3DAUBmCroipTYNEXQBYSiy7S-pKLZzka0VJpUEcaWEeOc0IMkzj4OKhhxTt03Zfrk9QVU2bR1dl8_o_1H0I-cPaJM8E_ayMYy1Uh3pAZzwRLcqXEAZkxxmQiCsYOyXvEO8Y4Zzx_Rw4Fz1KRczEjvy7tbZtsoEcb7KMNE130ejuhReoaurE_6GbqQwvBGno14j3SaqI32-B1sgbfON_p3gBd2YfR1nTZetfp4G69Htrp9_PPRegcDi34-HztAXH0QNetC8663j7pEEdk17qvoaNXGpFuBjAhxkDw0zF52-gtwsluHpGbLxfXy8tk9f3rt-VilWhZ8JAI3jRpKk2usqKuuanSTKlMKpDzSudS8bmUlQRpVAqqkLUELhqZsjo3UWsmj8jZS-7g3cMIGMo7N_pYBJaqyAqppFARfXxBxjtED005eNtpP5WclX_vUL7eIdrTXeBYdVC_yn_FR3C-AxqN3jY-1mhx71KRxZXzvdMG95_6f-EfGiKgOA</recordid><startdate>20110615</startdate><enddate>20110615</enddate><creator>Lung, Shih-Chun Candice</creator><creator>Liu, Chun-Hu</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20110615</creationdate><title>High-Sensitivity Analysis of Six Synthetic Musks by Ultra-Performance Liquid Chromatography–Atmospheric Pressure Photoionization–Tandem Mass Spectrometry</title><author>Lung, Shih-Chun Candice ; Liu, Chun-Hu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a371t-21ff443c6857dd1cb4588538e39ba6381933b3e3c84e873d3e12f340d6cd1ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Accuracy</topic><topic>Analytical chemistry</topic><topic>Applied sciences</topic><topic>Atmospheric pressure</topic><topic>Benzopyrans - analysis</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Exact sciences and technology</topic><topic>Global environmental pollution</topic><topic>Indans - analysis</topic><topic>Mass spectrometry</topic><topic>Other chromatographic methods</topic><topic>Pollution</topic><topic>Polycyclic Compounds - analysis</topic><topic>Spectrometric and optical methods</topic><topic>Tandem Mass Spectrometry - instrumentation</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Tetrahydronaphthalenes - analysis</topic><topic>Toxicity</topic><topic>Xylenes - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lung, Shih-Chun Candice</creatorcontrib><creatorcontrib>Liu, Chun-Hu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lung, Shih-Chun Candice</au><au>Liu, Chun-Hu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Sensitivity Analysis of Six Synthetic Musks by Ultra-Performance Liquid Chromatography–Atmospheric Pressure Photoionization–Tandem Mass Spectrometry</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2011-06-15</date><risdate>2011</risdate><volume>83</volume><issue>12</issue><spage>4955</spage><epage>4961</epage><pages>4955-4961</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>The occurrence and potential toxicity of synthetic musks in environmental media have aroused concerns for the impacts of these chemicals on ecosystems and human health. Here, we present the first method using ultra-performance liquid chromatography–atmospheric pressure photoionization–tandem mass spectrometry (UPLC-APPI-MS/MS) for analysis of the six most important synthetic musks. Analysis was performed on an API 3000 triple quadrupole equipped with a PhotoSpray APPI source. Two pairs of precursor/product ions are presented that are essential for confirmation. Chromatographic separation is completed in 7 min in the positive mode and 5.1 min in the negative mode. Furthermore, three dopant solutions (0.5% anisole in toluene, 0.5% 2,4-difluoroanisole (DFA) in bromobenzene, and 0.5% DFA in chlorobenzene) are compared in terms of sensitivity, linearity, precision, and accuracy. The best sensitivity is associated with 0.5% anisole in toluene as the dopant; all LODs are below 6 pg. The linear range is 5 to 500 ppb with fairly good precision and accuracy. This analytical method has also proven its applicability by analyzing real air samples. In summary, we present a fast, sensitive, and reliable UPLC-APPI-MS/MS method for six important synthetic musks; it can be readily applied to environmental studies.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>21542612</pmid><doi>10.1021/ac2006872</doi><tpages>7</tpages></addata></record> |
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| subjects | Accuracy Analytical chemistry Applied sciences Atmospheric pressure Benzopyrans - analysis Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, High Pressure Liquid - methods Exact sciences and technology Global environmental pollution Indans - analysis Mass spectrometry Other chromatographic methods Pollution Polycyclic Compounds - analysis Spectrometric and optical methods Tandem Mass Spectrometry - instrumentation Tandem Mass Spectrometry - methods Tetrahydronaphthalenes - analysis Toxicity Xylenes - analysis |
| title | High-Sensitivity Analysis of Six Synthetic Musks by Ultra-Performance Liquid Chromatography–Atmospheric Pressure Photoionization–Tandem Mass Spectrometry |
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