The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus
Background The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherap...
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| Veröffentlicht in: | Journal of gastroenterology 2011-07, Vol.46 (7), p.913-920 |
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| creator | Komatsu, Shohei Fukumoto, Takumi Demizu, Yusuke Miyawaki, Daisuke Terashima, Kazuki Niwa, Yasue Mima, Masayuki Fujii, Osamu Sasaki, Ryohei Yamada, Isamu Hori, Yuichi Hishikawa, Yoshio Abe, Mitsuyuki Ku, Yonson Murakami, Masao |
| description | Background
The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherapy for HCC with IVCTT.
Methods
Between June 2001 and January 2009, 16 evaluable patients who had HCC with IVCTT were treated with particle radiotherapy. They were divided into 2 groups: 6 were treated with curative intent; 10 with palliative intent. The local tumor control rates, overall survival rates, and toxicities were evaluated.
Results
All tumors treated with particle radiotherapy remained controlled without local recurrence at the last follow-up. The overall survival rates for the 16 patients at 1 and 3 years were 61.1 and 36.7%, respectively. We observed a significant difference in the survival rates according to treatment policy. The median survival time was 25.4 months for patients treated with curative intent and 7.7 months for those treated with palliative intent. The one-year survival rates were 100.0 and 33.3%, respectively. No Grade 3 or higher treatment-related toxicities were observed.
Conclusions
Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC. |
| doi_str_mv | 10.1007/s00535-011-0398-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_875721493</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714586114</galeid><sourcerecordid>A714586114</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-3fa92c9303a28b03070d7f9a4970c4ff4d8017ef42366c0d8494e94af3b782d63</originalsourceid><addsrcrecordid>eNp1kUtv1DAUhS0EosPAD2CDLFinXD8Sx8uq4iVVYlPWlse5blwl8WA7RfPv8SgFhATywvL1d8699iHkNYNLBqDeZ4BWtA0w1oDQfdM9ITsma6XVnD8lO9BSNowpeUFe5HwPwAS0_XNywVnLOq7bHTndjkjRe3QlPOCCOdPo6dGmEtyENNkhxDJisscT9THREY-2RIfTtE42UWeTC0ucLbU5RxdswYH-CGWkYfGYQlVUV1u5B0vLOtdzGVOcD2t-SZ55O2V89bjvybePH26vPzc3Xz99ub66aZzUUBrhreZOCxCW9wcQoGBQXlupFTjpvRx6YAq95KLrHAy91BK1tF4cVM-HTuzJ2833mOL3FXMx93FNS21petUqzqQWFXq3QXd2QlNnjyVZN4fszJVisu07Vj92Ty7_QdU14BxcXNCHWv9LwDaBSzHnhN4cU5htOhkG5hyh2SI0NUJzjtCc533zOO96mHH4rfiVWQX4BuR6tdxh-vOg_7v-BKgppuw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>875721493</pqid></control><display><type>article</type><title>The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Komatsu, Shohei ; Fukumoto, Takumi ; Demizu, Yusuke ; Miyawaki, Daisuke ; Terashima, Kazuki ; Niwa, Yasue ; Mima, Masayuki ; Fujii, Osamu ; Sasaki, Ryohei ; Yamada, Isamu ; Hori, Yuichi ; Hishikawa, Yoshio ; Abe, Mitsuyuki ; Ku, Yonson ; Murakami, Masao</creator><creatorcontrib>Komatsu, Shohei ; Fukumoto, Takumi ; Demizu, Yusuke ; Miyawaki, Daisuke ; Terashima, Kazuki ; Niwa, Yasue ; Mima, Masayuki ; Fujii, Osamu ; Sasaki, Ryohei ; Yamada, Isamu ; Hori, Yuichi ; Hishikawa, Yoshio ; Abe, Mitsuyuki ; Ku, Yonson ; Murakami, Masao</creatorcontrib><description>Background
The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherapy for HCC with IVCTT.
Methods
Between June 2001 and January 2009, 16 evaluable patients who had HCC with IVCTT were treated with particle radiotherapy. They were divided into 2 groups: 6 were treated with curative intent; 10 with palliative intent. The local tumor control rates, overall survival rates, and toxicities were evaluated.
Results
All tumors treated with particle radiotherapy remained controlled without local recurrence at the last follow-up. The overall survival rates for the 16 patients at 1 and 3 years were 61.1 and 36.7%, respectively. We observed a significant difference in the survival rates according to treatment policy. The median survival time was 25.4 months for patients treated with curative intent and 7.7 months for those treated with palliative intent. The one-year survival rates were 100.0 and 33.3%, respectively. No Grade 3 or higher treatment-related toxicities were observed.
Conclusions
Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-011-0398-6</identifier><identifier>PMID: 21516295</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Aged ; Aged, 80 and over ; Biliary Tract ; Blood clot ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - radiotherapy ; Care and treatment ; Colorectal Surgery ; Female ; Gastroenterology ; Health aspects ; Hepatology ; Hepatoma ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - radiotherapy ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplastic Cells, Circulating - radiation effects ; Original Article—Liver ; Pancreas ; Prognosis ; Radiotherapy ; Radiotherapy, High-Energy ; Surgical Oncology ; Survival Rate ; Thrombosis ; Tomography, X-Ray Computed ; Treatment Outcome ; Vena Cava, Inferior</subject><ispartof>Journal of gastroenterology, 2011-07, Vol.46 (7), p.913-920</ispartof><rights>Springer 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-3fa92c9303a28b03070d7f9a4970c4ff4d8017ef42366c0d8494e94af3b782d63</citedby><cites>FETCH-LOGICAL-c490t-3fa92c9303a28b03070d7f9a4970c4ff4d8017ef42366c0d8494e94af3b782d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-011-0398-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-011-0398-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21516295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komatsu, Shohei</creatorcontrib><creatorcontrib>Fukumoto, Takumi</creatorcontrib><creatorcontrib>Demizu, Yusuke</creatorcontrib><creatorcontrib>Miyawaki, Daisuke</creatorcontrib><creatorcontrib>Terashima, Kazuki</creatorcontrib><creatorcontrib>Niwa, Yasue</creatorcontrib><creatorcontrib>Mima, Masayuki</creatorcontrib><creatorcontrib>Fujii, Osamu</creatorcontrib><creatorcontrib>Sasaki, Ryohei</creatorcontrib><creatorcontrib>Yamada, Isamu</creatorcontrib><creatorcontrib>Hori, Yuichi</creatorcontrib><creatorcontrib>Hishikawa, Yoshio</creatorcontrib><creatorcontrib>Abe, Mitsuyuki</creatorcontrib><creatorcontrib>Ku, Yonson</creatorcontrib><creatorcontrib>Murakami, Masao</creatorcontrib><title>The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherapy for HCC with IVCTT.
Methods
Between June 2001 and January 2009, 16 evaluable patients who had HCC with IVCTT were treated with particle radiotherapy. They were divided into 2 groups: 6 were treated with curative intent; 10 with palliative intent. The local tumor control rates, overall survival rates, and toxicities were evaluated.
Results
All tumors treated with particle radiotherapy remained controlled without local recurrence at the last follow-up. The overall survival rates for the 16 patients at 1 and 3 years were 61.1 and 36.7%, respectively. We observed a significant difference in the survival rates according to treatment policy. The median survival time was 25.4 months for patients treated with curative intent and 7.7 months for those treated with palliative intent. The one-year survival rates were 100.0 and 33.3%, respectively. No Grade 3 or higher treatment-related toxicities were observed.
Conclusions
Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC.</description><subject>Abdominal Surgery</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biliary Tract</subject><subject>Blood clot</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - radiotherapy</subject><subject>Care and treatment</subject><subject>Colorectal Surgery</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplastic Cells, Circulating - radiation effects</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>Prognosis</subject><subject>Radiotherapy</subject><subject>Radiotherapy, High-Energy</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Thrombosis</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Vena Cava, Inferior</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtv1DAUhS0EosPAD2CDLFinXD8Sx8uq4iVVYlPWlse5blwl8WA7RfPv8SgFhATywvL1d8699iHkNYNLBqDeZ4BWtA0w1oDQfdM9ITsma6XVnD8lO9BSNowpeUFe5HwPwAS0_XNywVnLOq7bHTndjkjRe3QlPOCCOdPo6dGmEtyENNkhxDJisscT9THREY-2RIfTtE42UWeTC0ucLbU5RxdswYH-CGWkYfGYQlVUV1u5B0vLOtdzGVOcD2t-SZ55O2V89bjvybePH26vPzc3Xz99ub66aZzUUBrhreZOCxCW9wcQoGBQXlupFTjpvRx6YAq95KLrHAy91BK1tF4cVM-HTuzJ2833mOL3FXMx93FNS21petUqzqQWFXq3QXd2QlNnjyVZN4fszJVisu07Vj92Ty7_QdU14BxcXNCHWv9LwDaBSzHnhN4cU5htOhkG5hyh2SI0NUJzjtCc533zOO96mHH4rfiVWQX4BuR6tdxh-vOg_7v-BKgppuw</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Komatsu, Shohei</creator><creator>Fukumoto, Takumi</creator><creator>Demizu, Yusuke</creator><creator>Miyawaki, Daisuke</creator><creator>Terashima, Kazuki</creator><creator>Niwa, Yasue</creator><creator>Mima, Masayuki</creator><creator>Fujii, Osamu</creator><creator>Sasaki, Ryohei</creator><creator>Yamada, Isamu</creator><creator>Hori, Yuichi</creator><creator>Hishikawa, Yoshio</creator><creator>Abe, Mitsuyuki</creator><creator>Ku, Yonson</creator><creator>Murakami, Masao</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20110701</creationdate><title>The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus</title><author>Komatsu, Shohei ; Fukumoto, Takumi ; Demizu, Yusuke ; Miyawaki, Daisuke ; Terashima, Kazuki ; Niwa, Yasue ; Mima, Masayuki ; Fujii, Osamu ; Sasaki, Ryohei ; Yamada, Isamu ; Hori, Yuichi ; Hishikawa, Yoshio ; Abe, Mitsuyuki ; Ku, Yonson ; Murakami, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-3fa92c9303a28b03070d7f9a4970c4ff4d8017ef42366c0d8494e94af3b782d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Surgery</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biliary Tract</topic><topic>Blood clot</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - radiotherapy</topic><topic>Care and treatment</topic><topic>Colorectal Surgery</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - radiotherapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplastic Cells, Circulating - radiation effects</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>Prognosis</topic><topic>Radiotherapy</topic><topic>Radiotherapy, High-Energy</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Thrombosis</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Vena Cava, Inferior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komatsu, Shohei</creatorcontrib><creatorcontrib>Fukumoto, Takumi</creatorcontrib><creatorcontrib>Demizu, Yusuke</creatorcontrib><creatorcontrib>Miyawaki, Daisuke</creatorcontrib><creatorcontrib>Terashima, Kazuki</creatorcontrib><creatorcontrib>Niwa, Yasue</creatorcontrib><creatorcontrib>Mima, Masayuki</creatorcontrib><creatorcontrib>Fujii, Osamu</creatorcontrib><creatorcontrib>Sasaki, Ryohei</creatorcontrib><creatorcontrib>Yamada, Isamu</creatorcontrib><creatorcontrib>Hori, Yuichi</creatorcontrib><creatorcontrib>Hishikawa, Yoshio</creatorcontrib><creatorcontrib>Abe, Mitsuyuki</creatorcontrib><creatorcontrib>Ku, Yonson</creatorcontrib><creatorcontrib>Murakami, Masao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komatsu, Shohei</au><au>Fukumoto, Takumi</au><au>Demizu, Yusuke</au><au>Miyawaki, Daisuke</au><au>Terashima, Kazuki</au><au>Niwa, Yasue</au><au>Mima, Masayuki</au><au>Fujii, Osamu</au><au>Sasaki, Ryohei</au><au>Yamada, Isamu</au><au>Hori, Yuichi</au><au>Hishikawa, Yoshio</au><au>Abe, Mitsuyuki</au><au>Ku, Yonson</au><au>Murakami, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>46</volume><issue>7</issue><spage>913</spage><epage>920</epage><pages>913-920</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
The prognosis of patients who have hepatocellular carcinoma (HCC) associated with inferior vena cava tumor thrombus (IVCTT) is very poor, and effective treatment modalities are extremely limited. The objective of this study was to determine the therapeutic efficacy of particle radiotherapy for HCC with IVCTT.
Methods
Between June 2001 and January 2009, 16 evaluable patients who had HCC with IVCTT were treated with particle radiotherapy. They were divided into 2 groups: 6 were treated with curative intent; 10 with palliative intent. The local tumor control rates, overall survival rates, and toxicities were evaluated.
Results
All tumors treated with particle radiotherapy remained controlled without local recurrence at the last follow-up. The overall survival rates for the 16 patients at 1 and 3 years were 61.1 and 36.7%, respectively. We observed a significant difference in the survival rates according to treatment policy. The median survival time was 25.4 months for patients treated with curative intent and 7.7 months for those treated with palliative intent. The one-year survival rates were 100.0 and 33.3%, respectively. No Grade 3 or higher treatment-related toxicities were observed.
Conclusions
Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21516295</pmid><doi>10.1007/s00535-011-0398-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of gastroenterology, 2011-07, Vol.46 (7), p.913-920 |
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| subjects | Abdominal Surgery Aged Aged, 80 and over Biliary Tract Blood clot Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - radiotherapy Care and treatment Colorectal Surgery Female Gastroenterology Health aspects Hepatology Hepatoma Humans Liver Neoplasms - mortality Liver Neoplasms - radiotherapy Male Medicine Medicine & Public Health Middle Aged Neoplastic Cells, Circulating - radiation effects Original Article—Liver Pancreas Prognosis Radiotherapy Radiotherapy, High-Energy Surgical Oncology Survival Rate Thrombosis Tomography, X-Ray Computed Treatment Outcome Vena Cava, Inferior |
| title | The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus |
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