How Do Structure and Charge Affect Metal-Complex Binding to DNA? An Upper-Division Integrated Laboratory Project Using Cyclic Voltammetry

An advanced undergraduate laboratory project is described that integrates inorganic, analytical, physical, and biochemical techniques to reveal differences in binding between cationic metal complexes and anionic DNA (herring testes). Students were guided to formulate testable hypotheses based on the...

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Veröffentlicht in:	Journal of chemical education 2011-06, Vol.88 (6), p.801-805
Hauptverfasser:	Kulczynska, Agnieszka, Johnson, Reed, Frost, Tony, Margerum, Lawrence D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Binding Biochemistry Chemistry Cobalt College Science Complexity Cooperative Learning Coordination compounds Deoxyribonucleic acid Diffusion rate DNA Genetics Inquiry Laboratories Metal complexes Metallurgy Molecular structure Nonlinear analysis Organic chemistry Portfolios Science Experiments Science Instruction Science Laboratories Scientific Concepts Spectroscopy Students Teamwork Undergraduate Study Voltammetry
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