Effect of Chlorhexidine Pretreatment on the Stability of Salivary Lactobacilli Probiotic in Six- to Twelve-Year-Old Children: A Randomized Controlled Trial
This study aimed to investigate the efficacy of chlorhexidine mouthwash disinfection on the stability of lactobacilli probiotic. This study involved 105 children in 3 groups. Subjects in group A received chlorhexidine for 2 weeks, subjects of group B received probiotic yogurt containing Lactobacillu...
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| Veröffentlicht in: | Caries research 2011-05, Vol.45 (2), p.148-154 |
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| description | This study aimed to investigate the efficacy of chlorhexidine mouthwash disinfection on the stability of lactobacilli probiotic. This study involved 105 children in 3 groups. Subjects in group A received chlorhexidine for 2 weeks, subjects of group B received probiotic yogurt containing Lactobacillus rhamnosus GG (LGG) at a concentration of 2 × 10 8 colony-forming units per gram for 3 weeks, and subjects in group C received chlorhexidine in the same manner as group A and 24 h after cessation, they received probiotic yogurt in the same manner as group B. Salivary Streptococcus mutans (SM) and LGG were counted at baseline, 24 h, 1 week and 5 weeks after each intervention in all groups. The SM count was reduced 24 h after cessation of chlorhexidine in group A (p < 0.001), and was steady for 5 weeks (p < 0.05). In group B, SM counts did not show significant differences 5 weeks after ending the intake of the probiotic (p > 0.05); LGG counts increased (p < 0.001), but were not steady over 5 weeks. In group C, a significant reduction in SM count was recorded, and the reduced count was steady for 5 weeks; a significant increase in LGG counts was registered (p < 0.001), which was steady for 5 weeks. Intergroup comparison showed a significant increase in LGG counts in groups B and C; however, this increase was not steady in group B. Chlorhexidine treatment before probiotic intake induced more stable colonization with LGG strains than probiotic alone. |
| doi_str_mv | 10.1159/000325741 |
| format | Article |
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This study involved 105 children in 3 groups. Subjects in group A received chlorhexidine for 2 weeks, subjects of group B received probiotic yogurt containing Lactobacillus rhamnosus GG (LGG) at a concentration of 2 × 10 8 colony-forming units per gram for 3 weeks, and subjects in group C received chlorhexidine in the same manner as group A and 24 h after cessation, they received probiotic yogurt in the same manner as group B. Salivary Streptococcus mutans (SM) and LGG were counted at baseline, 24 h, 1 week and 5 weeks after each intervention in all groups. The SM count was reduced 24 h after cessation of chlorhexidine in group A (p < 0.001), and was steady for 5 weeks (p < 0.05). In group B, SM counts did not show significant differences 5 weeks after ending the intake of the probiotic (p > 0.05); LGG counts increased (p < 0.001), but were not steady over 5 weeks. In group C, a significant reduction in SM count was recorded, and the reduced count was steady for 5 weeks; a significant increase in LGG counts was registered (p < 0.001), which was steady for 5 weeks. Intergroup comparison showed a significant increase in LGG counts in groups B and C; however, this increase was not steady in group B. Chlorhexidine treatment before probiotic intake induced more stable colonization with LGG strains than probiotic alone.</description><identifier>ISSN: 0008-6568</identifier><identifier>EISSN: 1421-976X</identifier><identifier>DOI: 10.1159/000325741</identifier><identifier>PMID: 21454978</identifier><identifier>CODEN: CAREBK</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Analysis of Variance ; Antibiotic Prophylaxis ; Child ; Chlorhexidine - administration & dosage ; Chlorhexidine - pharmacology ; Colony Count, Microbial ; Dental Caries - prevention & control ; Dentistry ; Female ; Humans ; Lactobacillus rhamnosus ; Lactobacillus rhamnosus - growth & development ; Male ; Microbial Interactions - drug effects ; Mouthwashes - administration & dosage ; Mouthwashes - pharmacology ; Original Paper ; Probiotics - therapeutic use ; Saliva - microbiology ; Statistics, Nonparametric ; Streptococcus mutans ; Streptococcus mutans - drug effects ; Yogurt - microbiology</subject><ispartof>Caries research, 2011-05, Vol.45 (2), p.148-154</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-c4c0db868a20a5d0bb437abba6c76fdd7ab703298f4ec88ab7a6f4d9e1342b093</citedby><cites>FETCH-LOGICAL-c364t-c4c0db868a20a5d0bb437abba6c76fdd7ab703298f4ec88ab7a6f4d9e1342b093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21454978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aminabadi, N.A.</creatorcontrib><creatorcontrib>Erfanparast, L.</creatorcontrib><creatorcontrib>Ebrahimi, A.</creatorcontrib><creatorcontrib>Oskouei, S.G.</creatorcontrib><title>Effect of Chlorhexidine Pretreatment on the Stability of Salivary Lactobacilli Probiotic in Six- to Twelve-Year-Old Children: A Randomized Controlled Trial</title><title>Caries research</title><addtitle>Caries Res</addtitle><description>This study aimed to investigate the efficacy of chlorhexidine mouthwash disinfection on the stability of lactobacilli probiotic. This study involved 105 children in 3 groups. Subjects in group A received chlorhexidine for 2 weeks, subjects of group B received probiotic yogurt containing Lactobacillus rhamnosus GG (LGG) at a concentration of 2 × 10 8 colony-forming units per gram for 3 weeks, and subjects in group C received chlorhexidine in the same manner as group A and 24 h after cessation, they received probiotic yogurt in the same manner as group B. Salivary Streptococcus mutans (SM) and LGG were counted at baseline, 24 h, 1 week and 5 weeks after each intervention in all groups. The SM count was reduced 24 h after cessation of chlorhexidine in group A (p < 0.001), and was steady for 5 weeks (p < 0.05). In group B, SM counts did not show significant differences 5 weeks after ending the intake of the probiotic (p > 0.05); LGG counts increased (p < 0.001), but were not steady over 5 weeks. In group C, a significant reduction in SM count was recorded, and the reduced count was steady for 5 weeks; a significant increase in LGG counts was registered (p < 0.001), which was steady for 5 weeks. Intergroup comparison showed a significant increase in LGG counts in groups B and C; however, this increase was not steady in group B. Chlorhexidine treatment before probiotic intake induced more stable colonization with LGG strains than probiotic alone.</description><subject>Analysis of Variance</subject><subject>Antibiotic Prophylaxis</subject><subject>Child</subject><subject>Chlorhexidine - administration & dosage</subject><subject>Chlorhexidine - pharmacology</subject><subject>Colony Count, Microbial</subject><subject>Dental Caries - prevention & control</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Lactobacillus rhamnosus</subject><subject>Lactobacillus rhamnosus - growth & development</subject><subject>Male</subject><subject>Microbial Interactions - drug effects</subject><subject>Mouthwashes - administration & dosage</subject><subject>Mouthwashes - pharmacology</subject><subject>Original Paper</subject><subject>Probiotics - therapeutic use</subject><subject>Saliva - microbiology</subject><subject>Statistics, Nonparametric</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - drug effects</subject><subject>Yogurt - microbiology</subject><issn>0008-6568</issn><issn>1421-976X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1vEzEQhi0EoqFw4I6QxQVx2GJ7vV5vb1VUKFKkIhIkOK38MUtcvHbxOqXlr_TP1lFCDlw4eTzzzGvPvAi9pOSE0qZ7TwipWdNy-gjNKGe06lrx7TGalbysRCPkEXo2TVeEUC6EfIqOGOUN71o5Q_fnwwAm4zjg-drHtIZbZ10A_DlBTqDyCKFUA85rwMustPMu323xpfLuRqU7vFAmR62M896VtqhdzM5gF_DS3VY4R7z6Df4Gqu-gUnXpbXnJeZsgnOIz_EUFG0f3B0o6hpyi9yVcJaf8c_RkUH6CF_vzGH39cL6aX1SLy4-f5meLytSC58pwQ6yWQipGVGOJ1rxuldZKmFYM1pa4Lfvp5MDBSFluSgzcdkBrzjTp6mP0dqd7neKvDUy5H91kwHsVIG6mXraC1Q2T8v-k6JqO1WxLvvmHvIqbFMoYRY6TuvycFujdDjIpTlOCob9Obiw77Snpt872B2cL-3ovuNEj2AP518oCvNoBP1X6AekA7PsfANlzqDo</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Aminabadi, N.A.</creator><creator>Erfanparast, L.</creator><creator>Ebrahimi, A.</creator><creator>Oskouei, S.G.</creator><general>S. 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Erfanparast, L. ; Ebrahimi, A. ; Oskouei, S.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-c4c0db868a20a5d0bb437abba6c76fdd7ab703298f4ec88ab7a6f4d9e1342b093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analysis of Variance</topic><topic>Antibiotic Prophylaxis</topic><topic>Child</topic><topic>Chlorhexidine - administration & dosage</topic><topic>Chlorhexidine - pharmacology</topic><topic>Colony Count, Microbial</topic><topic>Dental Caries - prevention & control</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Lactobacillus rhamnosus</topic><topic>Lactobacillus rhamnosus - growth & development</topic><topic>Male</topic><topic>Microbial Interactions - drug effects</topic><topic>Mouthwashes - administration & dosage</topic><topic>Mouthwashes - pharmacology</topic><topic>Original Paper</topic><topic>Probiotics - therapeutic use</topic><topic>Saliva - microbiology</topic><topic>Statistics, Nonparametric</topic><topic>Streptococcus mutans</topic><topic>Streptococcus mutans - drug effects</topic><topic>Yogurt - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aminabadi, N.A.</creatorcontrib><creatorcontrib>Erfanparast, L.</creatorcontrib><creatorcontrib>Ebrahimi, A.</creatorcontrib><creatorcontrib>Oskouei, S.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Caries research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aminabadi, N.A.</au><au>Erfanparast, L.</au><au>Ebrahimi, A.</au><au>Oskouei, S.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Chlorhexidine Pretreatment on the Stability of Salivary Lactobacilli Probiotic in Six- to Twelve-Year-Old Children: A Randomized Controlled Trial</atitle><jtitle>Caries research</jtitle><addtitle>Caries Res</addtitle><date>2011-05</date><risdate>2011</risdate><volume>45</volume><issue>2</issue><spage>148</spage><epage>154</epage><pages>148-154</pages><issn>0008-6568</issn><eissn>1421-976X</eissn><coden>CAREBK</coden><abstract>This study aimed to investigate the efficacy of chlorhexidine mouthwash disinfection on the stability of lactobacilli probiotic. This study involved 105 children in 3 groups. Subjects in group A received chlorhexidine for 2 weeks, subjects of group B received probiotic yogurt containing Lactobacillus rhamnosus GG (LGG) at a concentration of 2 × 10 8 colony-forming units per gram for 3 weeks, and subjects in group C received chlorhexidine in the same manner as group A and 24 h after cessation, they received probiotic yogurt in the same manner as group B. Salivary Streptococcus mutans (SM) and LGG were counted at baseline, 24 h, 1 week and 5 weeks after each intervention in all groups. The SM count was reduced 24 h after cessation of chlorhexidine in group A (p < 0.001), and was steady for 5 weeks (p < 0.05). In group B, SM counts did not show significant differences 5 weeks after ending the intake of the probiotic (p > 0.05); LGG counts increased (p < 0.001), but were not steady over 5 weeks. In group C, a significant reduction in SM count was recorded, and the reduced count was steady for 5 weeks; a significant increase in LGG counts was registered (p < 0.001), which was steady for 5 weeks. Intergroup comparison showed a significant increase in LGG counts in groups B and C; however, this increase was not steady in group B. Chlorhexidine treatment before probiotic intake induced more stable colonization with LGG strains than probiotic alone.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21454978</pmid><doi>10.1159/000325741</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Antibiotic Prophylaxis Child Chlorhexidine - administration & dosage Chlorhexidine - pharmacology Colony Count, Microbial Dental Caries - prevention & control Dentistry Female Humans Lactobacillus rhamnosus Lactobacillus rhamnosus - growth & development Male Microbial Interactions - drug effects Mouthwashes - administration & dosage Mouthwashes - pharmacology Original Paper Probiotics - therapeutic use Saliva - microbiology Statistics, Nonparametric Streptococcus mutans Streptococcus mutans - drug effects Yogurt - microbiology |
| title | Effect of Chlorhexidine Pretreatment on the Stability of Salivary Lactobacilli Probiotic in Six- to Twelve-Year-Old Children: A Randomized Controlled Trial |
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