Insulin modulation of ATP-sensitive K+ channel of rat skeletal muscle is impaired in the hypokalaemic state

In the present work, we examined the effects of in vivo administration of insulin to rats made hypokalaemic by feeding a K+-free diet. The i.p. injection of insulin in the hypokalaemic rats provoked muscle paralysis within 3-5 h. Consistent with this observation, the skeletal muscle fibres of the pa...

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Veröffentlicht in:	Pflügers Archiv 1999-01, Vol.437 (2), p.235-240
Hauptverfasser:	Tricarico, D, Capriulo, R, Conte Camerino, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Diet Glyburide - pharmacology Hypoglycemic Agents - pharmacology Hypokalemia - metabolism Insulin - pharmacology Male Microelectrodes Muscle Fibers, Skeletal - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular system Paralysis - chemically induced Paralysis - physiopathology Patch-Clamp Techniques Potassium Channels - drug effects Potassium Channels - metabolism Rats Rats, Wistar Rodents Sarcolemma - drug effects Sarcolemma - metabolism
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