Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells

Pluripotent cells referred to as embryonic germ cells (EGCs) can be derived from the embryonic precursors of the mature gametes: the primordial germ cells (PGCs). A homozygous mutation ( ter) of the dead-end homolog 1 gene ( Dnd1) in the rat causes gonadal teratocarcinogenesis and sterility due to n...

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Veröffentlicht in:	Experimental cell research 2011-08, Vol.317 (13), p.1885-1894
Hauptverfasser:	Northrup, Emily, Eisenblätter, Regina, Glage, Silke, Rudolph, Cornelia, Dorsch, Martina, Schlegelberger, Brigitte, Hedrich, Hans-Jürgen, Zschemisch, Nils-Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cellular biology Dnd1 Embryonic germ cell Female Genes, Tumor Suppressor Genotype & phenotype Germ Cells - cytology Germ Cells - metabolism Germ-line competent chimera Male Population genetics Primordial germ cell Rat Rats Rats, Inbred Strains RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Rodents Teratoma Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors
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