Serial Interferon Gamma Release Assay in Latent Tuberculosis Infection
The aim of this report is to present results of serial interferon-gamma (IFN-[gamma]) determination (QuantiFERON-TB Gold In-Tube assay) in a 57-year-old BCG-vaccinated female health care worker with a latent tuberculosis infection. Increased IFN-[gamma], IgA, and anti-thyroglobulin (anti-Tg) autoant...
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| Veröffentlicht in: | Laboratory medicine 2009-11, Vol.40 (11), p.681 |
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| creator | Dodig, Slavica Zrinski-TopiÄ, Renata |
| description | The aim of this report is to present results of serial interferon-gamma (IFN-[gamma]) determination (QuantiFERON-TB Gold In-Tube assay) in a 57-year-old BCG-vaccinated female health care worker with a latent tuberculosis infection. Increased IFN-[gamma], IgA, and anti-thyroglobulin (anti-Tg) autoantibodies were recorded throughout a 13-month follow-up. After 13 months the subject was clinically healthy and free from any signs and symptoms of active tuberculosis. The increased levels of anti-Tg autoantibodies may have been a concurrent process that did not impair the patient's immune status. Since false-positive IgA could be found in patients suffering from autoimmune thyroid diseases, it could be assumed increased IgA in this subject is a result of the positive interferences of goat anti-IgA antibodies. Although isoniazid prophylaxis was not used, tuberculosis did not develop during the follow-up period. Serial determination of IFN-[gamma] is necessary due to occupational exposure to tubercle bacilli. |
| doi_str_mv | 10.1309/LMJ62BPKL7AKRVYJ |
| format | Article |
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Increased IFN-[gamma], IgA, and anti-thyroglobulin (anti-Tg) autoantibodies were recorded throughout a 13-month follow-up. After 13 months the subject was clinically healthy and free from any signs and symptoms of active tuberculosis. The increased levels of anti-Tg autoantibodies may have been a concurrent process that did not impair the patient's immune status. Since false-positive IgA could be found in patients suffering from autoimmune thyroid diseases, it could be assumed increased IgA in this subject is a result of the positive interferences of goat anti-IgA antibodies. Although isoniazid prophylaxis was not used, tuberculosis did not develop during the follow-up period. Serial determination of IFN-[gamma] is necessary due to occupational exposure to tubercle bacilli.</description><identifier>ISSN: 0007-5027</identifier><identifier>DOI: 10.1309/LMJ62BPKL7AKRVYJ</identifier><language>eng</language><publisher>Chicago: Oxford University Press</publisher><subject>Antitubercular agents ; Autoantibodies ; Autoimmunity ; Biological response modifiers ; Development and progression ; Disease susceptibility ; Immunoglobulin A ; Interferon gamma ; Internal medicine ; Medical diagnosis ; Thyroid diseases ; Tuberculosis ; Vaccination</subject><ispartof>Laboratory medicine, 2009-11, Vol.40 (11), p.681</ispartof><rights>COPYRIGHT 2009 Oxford University Press</rights><rights>Copyright American Society of Clinical Pathologists Nov 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Dodig, Slavica</creatorcontrib><creatorcontrib>Zrinski-TopiÄ, Renata</creatorcontrib><title>Serial Interferon Gamma Release Assay in Latent Tuberculosis Infection</title><title>Laboratory medicine</title><description>The aim of this report is to present results of serial interferon-gamma (IFN-[gamma]) determination (QuantiFERON-TB Gold In-Tube assay) in a 57-year-old BCG-vaccinated female health care worker with a latent tuberculosis infection. Increased IFN-[gamma], IgA, and anti-thyroglobulin (anti-Tg) autoantibodies were recorded throughout a 13-month follow-up. After 13 months the subject was clinically healthy and free from any signs and symptoms of active tuberculosis. The increased levels of anti-Tg autoantibodies may have been a concurrent process that did not impair the patient's immune status. Since false-positive IgA could be found in patients suffering from autoimmune thyroid diseases, it could be assumed increased IgA in this subject is a result of the positive interferences of goat anti-IgA antibodies. Although isoniazid prophylaxis was not used, tuberculosis did not develop during the follow-up period. 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| ispartof | Laboratory medicine, 2009-11, Vol.40 (11), p.681 |
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| language | eng |
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| source | Oxford University Press; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antitubercular agents Autoantibodies Autoimmunity Biological response modifiers Development and progression Disease susceptibility Immunoglobulin A Interferon gamma Internal medicine Medical diagnosis Thyroid diseases Tuberculosis Vaccination |
| title | Serial Interferon Gamma Release Assay in Latent Tuberculosis Infection |
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