Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance
MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expressi...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2010-09, Vol.27 (3), p.685-689 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Zhang, Yuanyuan Guo, Junming Li, Dong Xiao, Bingxiu Miao, Ying Jiang, Zhen Zhuo, Hui |
| description | MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer. |
| doi_str_mv | 10.1007/s12032-009-9269-x |
| format | Article |
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Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-009-9269-x</identifier><identifier>PMID: 19598010</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Aged ; Biomarkers, Tumor - blood ; Breast - metabolism ; Carcinoembryonic Antigen - blood ; Carcinoma - diagnosis ; Carcinoma - etiology ; Carcinoma - genetics ; Carcinoma - metabolism ; Cell Transformation, Neoplastic - genetics ; Colon - metabolism ; Computer Systems ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic ; Hematology ; Humans ; Internal Medicine ; Lung - metabolism ; Male ; Medicine ; Medicine & Public Health ; MicroRNAs - biosynthesis ; MicroRNAs - genetics ; MicroRNAs - physiology ; Middle Aged ; Oncology ; Organ Specificity ; Original Paper ; Pathology ; Predictive Value of Tests ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Neoplasm - biosynthesis ; RNA, Neoplasm - genetics ; RNA, Neoplasm - physiology ; Stomach - metabolism ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - etiology ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism</subject><ispartof>Medical oncology (Northwood, London, England), 2010-09, Vol.27 (3), p.685-689</ispartof><rights>Humana Press Inc. 2009</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-1d6241c502f9d4701e8caa460936f060cb5aa8605898241d7bde80a1b68e6aec3</citedby><cites>FETCH-LOGICAL-c436t-1d6241c502f9d4701e8caa460936f060cb5aa8605898241d7bde80a1b68e6aec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-009-9269-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-009-9269-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19598010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Guo, Junming</creatorcontrib><creatorcontrib>Li, Dong</creatorcontrib><creatorcontrib>Xiao, Bingxiu</creatorcontrib><creatorcontrib>Miao, Ying</creatorcontrib><creatorcontrib>Jiang, Zhen</creatorcontrib><creatorcontrib>Zhuo, Hui</creatorcontrib><title>Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.</description><subject>Aged</subject><subject>Biomarkers, Tumor - blood</subject><subject>Breast - metabolism</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - etiology</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Colon - metabolism</subject><subject>Computer Systems</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs - biosynthesis</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - physiology</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Organ Specificity</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Predictive Value of Tests</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Neoplasm - biosynthesis</subject><subject>RNA, Neoplasm - genetics</subject><subject>RNA, Neoplasm - physiology</subject><subject>Stomach - metabolism</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - etiology</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBcJ3qMz2Sa7OUr9hIIgCh6EkM1mS0qbrckW6783tQVPnjJknnlneAg5R7hCgPI6IYeCMwDFFJeKbQ7IEIVQDAt8P8x1IUoGQsKAnKQ0B-AouDomA1RCVYAwJB-33Vdg0c3WC9P7LtCupUv_wgqkbrOKLqXtpw90ZlIfvaXWBOsi7X1Ka5eoCQ31faJ24YO3ZkGTnwXf-l_slBy1ZpHc2f4dkbf7u9fJI5s-PzxNbqbMjgvZM2wkH6MVwFvVjEtAV1ljxhJUIVuQYGthTCVBVKrKYFPWjavAYC0rJ42zxYhc7nJXsfvMV_V63q1jyCt1VXIolUCZIdxBNnYpRdfqVfRLE781gt7q1DudOuvUW516k2cu9sHreumav4m9vwzwHZByK8xc_Nv8f-oPocSAkQ</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Zhang, Yuanyuan</creator><creator>Guo, Junming</creator><creator>Li, Dong</creator><creator>Xiao, Bingxiu</creator><creator>Miao, Ying</creator><creator>Jiang, Zhen</creator><creator>Zhuo, Hui</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20100901</creationdate><title>Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance</title><author>Zhang, Yuanyuan ; Guo, Junming ; Li, Dong ; Xiao, Bingxiu ; Miao, Ying ; Jiang, Zhen ; Zhuo, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-1d6241c502f9d4701e8caa460936f060cb5aa8605898241d7bde80a1b68e6aec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - blood</topic><topic>Breast - metabolism</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - etiology</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Colon - metabolism</topic><topic>Computer Systems</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNAs - biosynthesis</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - physiology</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Organ Specificity</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Predictive Value of Tests</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Neoplasm - biosynthesis</topic><topic>RNA, Neoplasm - genetics</topic><topic>RNA, Neoplasm - physiology</topic><topic>Stomach - metabolism</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - etiology</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Guo, Junming</creatorcontrib><creatorcontrib>Li, Dong</creatorcontrib><creatorcontrib>Xiao, Bingxiu</creatorcontrib><creatorcontrib>Miao, Ying</creatorcontrib><creatorcontrib>Jiang, Zhen</creatorcontrib><creatorcontrib>Zhuo, Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yuanyuan</au><au>Guo, Junming</au><au>Li, Dong</au><au>Xiao, Bingxiu</au><au>Miao, Ying</au><au>Jiang, Zhen</au><au>Zhuo, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>27</volume><issue>3</issue><spage>685</spage><epage>689</epage><pages>685-689</pages><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19598010</pmid><doi>10.1007/s12032-009-9269-x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Medical oncology (Northwood, London, England), 2010-09, Vol.27 (3), p.685-689 |
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| subjects | Aged Biomarkers, Tumor - blood Breast - metabolism Carcinoembryonic Antigen - blood Carcinoma - diagnosis Carcinoma - etiology Carcinoma - genetics Carcinoma - metabolism Cell Transformation, Neoplastic - genetics Colon - metabolism Computer Systems Down-Regulation Female Gene Expression Regulation, Neoplastic Hematology Humans Internal Medicine Lung - metabolism Male Medicine Medicine & Public Health MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - physiology Middle Aged Oncology Organ Specificity Original Paper Pathology Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics RNA, Neoplasm - physiology Stomach - metabolism Stomach Neoplasms - diagnosis Stomach Neoplasms - etiology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism |
| title | Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance |
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