Synthesis and characterization of pyrazine-2-carbohydrazide derivatives as antimicrobial agents
A series of pyrazine-2-carbohydrazide derivatives has been synthesized and assessed for their in vitro antimicrobial activity against Gram-positive and Gram-negative strains of bacteria. In the present study, pyrazinamide was hydrolyzed and esteriÞ ed to obtain ethyl-pyrazinoate and was reacted with...
Gespeichert in:
| Veröffentlicht in: | Journal of young pharmacists 2009-04, Vol.1 (2), p.165 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | 165 |
| container_title | Journal of young pharmacists |
| container_volume | 1 |
| creator | Miniyar, P Makhija, S |
| description | A series of pyrazine-2-carbohydrazide derivatives has been synthesized and assessed for their in vitro antimicrobial activity against Gram-positive and Gram-negative strains of bacteria. In the present study, pyrazinamide was hydrolyzed and esteriÞ ed to obtain ethyl-pyrazinoate and was reacted with hydrazine hydrate to yield the pyrazinoic acid hydrazide. This pyrazinoic acid hydrazide was then condensed with various substituted aromatic aldehydes to obtain different derivatives of pyrazine-2-carbohydrazide. The newly synthesized compounds were characterized by IR, 1HNMR and MS spectral data. The antimicrobial activity of the synthesized compounds was found to be potent against the selected strains of Gram-positive bacteria as compared with Gram-negative bacteria. |
| doi_str_mv | 10.4103/0975-1483.55750 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_871227293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A208077458</galeid><sourcerecordid>A208077458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c321t-91272bdfeb76dafe186bf2b1202500617d583f889f06280525dfa22062ca3b103</originalsourceid><addsrcrecordid>eNp9kUtPAyEUhYnRxEa7djvR9bQ8hoFZNo2vpIkLdU2YAVqaFirQJu2vl7GaaKLCArh899zkHACuEBxVCJIxbBgtUcXJiFJG4QkYHCsU0tOve_49B8MYl7BfDDLSDIB43ru00NHGQjpVdAsZZJd0sAeZrHeFN8VmH-TBOl3ispOh9Yu96gtKFypzu8ztdO7uBZJd2y741spVIefapXgJzoxcRT38PC_A693ty_ShnD3dP04ns7IjGKWyQZjhVhndslpJoxGvW4NbhCGmENaIKcqJ4bwxsMYcUkyVkRjnRydJmx24ANdH3U3wb1sdk1j6bXB5pOAM4azekAzd_AVhXDU86yP-L5UHYohq9o2ay5UW1hmfsnNrGzsxwZBDxiraU6NfqLyVzk55p43N9R8N42NDtjHGoI3YBLuWYS8QFH3Uog9T9GGKj6jJO0TfmGo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2062201678</pqid></control><display><type>article</type><title>Synthesis and characterization of pyrazine-2-carbohydrazide derivatives as antimicrobial agents</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Miniyar, P ; Makhija, S</creator><creatorcontrib>Miniyar, P ; Makhija, S</creatorcontrib><description>A series of pyrazine-2-carbohydrazide derivatives has been synthesized and assessed for their in vitro antimicrobial activity against Gram-positive and Gram-negative strains of bacteria. In the present study, pyrazinamide was hydrolyzed and esteriÞ ed to obtain ethyl-pyrazinoate and was reacted with hydrazine hydrate to yield the pyrazinoic acid hydrazide. This pyrazinoic acid hydrazide was then condensed with various substituted aromatic aldehydes to obtain different derivatives of pyrazine-2-carbohydrazide. The newly synthesized compounds were characterized by IR, 1HNMR and MS spectral data. The antimicrobial activity of the synthesized compounds was found to be potent against the selected strains of Gram-positive bacteria as compared with Gram-negative bacteria.</description><identifier>ISSN: 0975-1483</identifier><identifier>EISSN: 0975-1505</identifier><identifier>DOI: 10.4103/0975-1483.55750</identifier><language>eng</language><publisher>Bangalore: Medknow Publications and Media Pvt. Ltd</publisher><subject>Acids ; Anti-infective agents ; Antimicrobial agents ; Bacteria ; Bacterial infections ; Derivatives ; Dosage and administration ; Drug resistance ; Drug therapy ; Drugs ; E coli ; Ethanol ; Gram-positive bacteria ; Identification and classification ; Microbiology ; Product/Service Evaluations</subject><ispartof>Journal of young pharmacists, 2009-04, Vol.1 (2), p.165</ispartof><rights>COPYRIGHT 2009 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright InPharm Apr/Jun 2009</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Apr 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-91272bdfeb76dafe186bf2b1202500617d583f889f06280525dfa22062ca3b103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Miniyar, P</creatorcontrib><creatorcontrib>Makhija, S</creatorcontrib><title>Synthesis and characterization of pyrazine-2-carbohydrazide derivatives as antimicrobial agents</title><title>Journal of young pharmacists</title><description>A series of pyrazine-2-carbohydrazide derivatives has been synthesized and assessed for their in vitro antimicrobial activity against Gram-positive and Gram-negative strains of bacteria. In the present study, pyrazinamide was hydrolyzed and esteriÞ ed to obtain ethyl-pyrazinoate and was reacted with hydrazine hydrate to yield the pyrazinoic acid hydrazide. This pyrazinoic acid hydrazide was then condensed with various substituted aromatic aldehydes to obtain different derivatives of pyrazine-2-carbohydrazide. The newly synthesized compounds were characterized by IR, 1HNMR and MS spectral data. The antimicrobial activity of the synthesized compounds was found to be potent against the selected strains of Gram-positive bacteria as compared with Gram-negative bacteria.</description><subject>Acids</subject><subject>Anti-infective agents</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Derivatives</subject><subject>Dosage and administration</subject><subject>Drug resistance</subject><subject>Drug therapy</subject><subject>Drugs</subject><subject>E coli</subject><subject>Ethanol</subject><subject>Gram-positive bacteria</subject><subject>Identification and classification</subject><subject>Microbiology</subject><subject>Product/Service Evaluations</subject><issn>0975-1483</issn><issn>0975-1505</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUtPAyEUhYnRxEa7djvR9bQ8hoFZNo2vpIkLdU2YAVqaFirQJu2vl7GaaKLCArh899zkHACuEBxVCJIxbBgtUcXJiFJG4QkYHCsU0tOve_49B8MYl7BfDDLSDIB43ru00NHGQjpVdAsZZJd0sAeZrHeFN8VmH-TBOl3ispOh9Yu96gtKFypzu8ztdO7uBZJd2y741spVIefapXgJzoxcRT38PC_A693ty_ShnD3dP04ns7IjGKWyQZjhVhndslpJoxGvW4NbhCGmENaIKcqJ4bwxsMYcUkyVkRjnRydJmx24ANdH3U3wb1sdk1j6bXB5pOAM4azekAzd_AVhXDU86yP-L5UHYohq9o2ay5UW1hmfsnNrGzsxwZBDxiraU6NfqLyVzk55p43N9R8N42NDtjHGoI3YBLuWYS8QFH3Uog9T9GGKj6jJO0TfmGo</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Miniyar, P</creator><creator>Makhija, S</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>InPharm</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20090401</creationdate><title>Synthesis and characterization of pyrazine-2-carbohydrazide derivatives as antimicrobial agents</title><author>Miniyar, P ; Makhija, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-91272bdfeb76dafe186bf2b1202500617d583f889f06280525dfa22062ca3b103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acids</topic><topic>Anti-infective agents</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Derivatives</topic><topic>Dosage and administration</topic><topic>Drug resistance</topic><topic>Drug therapy</topic><topic>Drugs</topic><topic>E coli</topic><topic>Ethanol</topic><topic>Gram-positive bacteria</topic><topic>Identification and classification</topic><topic>Microbiology</topic><topic>Product/Service Evaluations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miniyar, P</creatorcontrib><creatorcontrib>Makhija, S</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of young pharmacists</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miniyar, P</au><au>Makhija, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of pyrazine-2-carbohydrazide derivatives as antimicrobial agents</atitle><jtitle>Journal of young pharmacists</jtitle><date>2009-04-01</date><risdate>2009</risdate><volume>1</volume><issue>2</issue><spage>165</spage><pages>165-</pages><issn>0975-1483</issn><eissn>0975-1505</eissn><abstract>A series of pyrazine-2-carbohydrazide derivatives has been synthesized and assessed for their in vitro antimicrobial activity against Gram-positive and Gram-negative strains of bacteria. In the present study, pyrazinamide was hydrolyzed and esteriÞ ed to obtain ethyl-pyrazinoate and was reacted with hydrazine hydrate to yield the pyrazinoic acid hydrazide. This pyrazinoic acid hydrazide was then condensed with various substituted aromatic aldehydes to obtain different derivatives of pyrazine-2-carbohydrazide. The newly synthesized compounds were characterized by IR, 1HNMR and MS spectral data. The antimicrobial activity of the synthesized compounds was found to be potent against the selected strains of Gram-positive bacteria as compared with Gram-negative bacteria.</abstract><cop>Bangalore</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><doi>10.4103/0975-1483.55750</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0975-1483 |
| ispartof | Journal of young pharmacists, 2009-04, Vol.1 (2), p.165 |
| issn | 0975-1483 0975-1505 |
| language | eng |
| recordid | cdi_proquest_journals_871227293 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acids Anti-infective agents Antimicrobial agents Bacteria Bacterial infections Derivatives Dosage and administration Drug resistance Drug therapy Drugs E coli Ethanol Gram-positive bacteria Identification and classification Microbiology Product/Service Evaluations |
| title | Synthesis and characterization of pyrazine-2-carbohydrazide derivatives as antimicrobial agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T11%3A35%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20characterization%20of%20pyrazine-2-carbohydrazide%20derivatives%20as%20antimicrobial%20agents&rft.jtitle=Journal%20of%20young%20pharmacists&rft.au=Miniyar,%20P&rft.date=2009-04-01&rft.volume=1&rft.issue=2&rft.spage=165&rft.pages=165-&rft.issn=0975-1483&rft.eissn=0975-1505&rft_id=info:doi/10.4103/0975-1483.55750&rft_dat=%3Cgale_proqu%3EA208077458%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2062201678&rft_id=info:pmid/&rft_galeid=A208077458&rfr_iscdi=true |