Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients
Goals of work Advanced colorectal cancer (CRC) has recently been treated with monoclonal antibodies, such as cetuximab. Skin toxicity is a peculiar side effect of cetuximab that may induce patients to interrupt therapy if it becomes serious. This study investigates the psychological and social seque...
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| Veröffentlicht in: | Supportive care in cancer 2010-03, Vol.18 (3), p.329-334 |
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| creator | Romito, Francesca Giuliani, Francesco Cormio, Claudia Tulipani, Cinzia Mattioli, Vittorio Colucci, Giuseppe |
| description | Goals of work
Advanced colorectal cancer (CRC) has recently been treated with monoclonal antibodies, such as cetuximab. Skin toxicity is a peculiar side effect of cetuximab that may induce patients to interrupt therapy if it becomes serious. This study investigates the psychological and social sequelae of skin rash.
Materials and methods
Patients affected by advanced CRC and treated with cetuximab-based therapy entered the trial. The following questionnaires were used: the Functional Assessment of Cancer Therapy—Colorectal (FACT-C) to measure quality of life (QoL) and the Psychological Distress Inventory (PDI). A single item regarding social avoidance was added with a three-point Likert scale. Toxicity was assessed using the National Cancer Institute Criteria (NCI-2).
Main results
Eighty patients were recruited; 41% presented psychological distress. As regards social avoidance, 53% of patients answered that they did not avoid going out at all. The rest of the sample answered that they “very much” (22%) or “somewhat” (25%) avoided going out. Psychological distress and social avoidance were not correlated to skin rash, but only to QoL.
Conclusion
Skin rash was not found to impact patients' psychological status or social life. Two likely explanations for this finding were that (a) patients with advanced cancer consider skin rash as a part of the complex suffering caused by cancer and (b) patients are encouraged by oncologists to continue treatment because skin rash is indicative of response to therapy. This expectation brings hope and helps patients bear the drug-related side effects. |
| doi_str_mv | 10.1007/s00520-009-0656-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_869445679</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A358058198</galeid><sourcerecordid>A358058198</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-3bf7921a2ae73fafb18bf9e16fd02777eaa16a4c2949e91a7a3e436ad12288a43</originalsourceid><addsrcrecordid>eNp1kU-LFDEQxYMo7rj6AbxIo-es-dvpHJdFXWFBD3qO1enKbJaZZEy6Zffbm7EHFkHJIVD1e68qeYS85uyCM2beV8a0YJQxS1mve2qfkA1XUlIjpX1KNswqTpXU-oy8qPWOMW6MFs_JGbdqUGowG_Lja33wt3mXt9HDrsMQ0M-1y6HzOC_3cQ8jjWlaPE6dX2ZImJfaFai3XUwdTL8g_Wk1h9KUzcIfK6U7wBwxzfUleRZgV_HV6T4n3z9--HZ1TW--fPp8dXlDvWZypnIMxgoOAtDIAGHkwxgs8j5MTBhjEID3oLywyqLlYECikj1MXIhhACXPydvV91DyzwXr7O7yUlIb6YbeKqV7Yxv0boW2sEMXU8hzAb-P1btLqQemB26HRl38g2pnwn30OWGIrf6XgK8CX3KtBYM7lPZz5cFx5o5JuTUp15Jyx6TccZU3p32XcY_To-IUTQPECtTWSlssjw_6v-tvUKyeIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>869445679</pqid></control><display><type>article</type><title>Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Romito, Francesca ; Giuliani, Francesco ; Cormio, Claudia ; Tulipani, Cinzia ; Mattioli, Vittorio ; Colucci, Giuseppe</creator><creatorcontrib>Romito, Francesca ; Giuliani, Francesco ; Cormio, Claudia ; Tulipani, Cinzia ; Mattioli, Vittorio ; Colucci, Giuseppe</creatorcontrib><description>Goals of work
Advanced colorectal cancer (CRC) has recently been treated with monoclonal antibodies, such as cetuximab. Skin toxicity is a peculiar side effect of cetuximab that may induce patients to interrupt therapy if it becomes serious. This study investigates the psychological and social sequelae of skin rash.
Materials and methods
Patients affected by advanced CRC and treated with cetuximab-based therapy entered the trial. The following questionnaires were used: the Functional Assessment of Cancer Therapy—Colorectal (FACT-C) to measure quality of life (QoL) and the Psychological Distress Inventory (PDI). A single item regarding social avoidance was added with a three-point Likert scale. Toxicity was assessed using the National Cancer Institute Criteria (NCI-2).
Main results
Eighty patients were recruited; 41% presented psychological distress. As regards social avoidance, 53% of patients answered that they did not avoid going out at all. The rest of the sample answered that they “very much” (22%) or “somewhat” (25%) avoided going out. Psychological distress and social avoidance were not correlated to skin rash, but only to QoL.
Conclusion
Skin rash was not found to impact patients' psychological status or social life. Two likely explanations for this finding were that (a) patients with advanced cancer consider skin rash as a part of the complex suffering caused by cancer and (b) patients are encouraged by oncologists to continue treatment because skin rash is indicative of response to therapy. This expectation brings hope and helps patients bear the drug-related side effects.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-009-0656-9</identifier><identifier>PMID: 19484487</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Antibodies, Monoclonal - adverse effects ; Antibodies, Monoclonal, Humanized ; Antimitotic agents ; Antineoplastic agents ; Antineoplastic Agents - adverse effects ; Anxiety - psychology ; Cancer ; Cancer patients ; Care and treatment ; Cetuximab ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Drug Eruptions - etiology ; Drug Eruptions - psychology ; Female ; Health aspects ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Monoclonal antibodies ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Personality Inventory ; Population Surveillance - methods ; Psychological aspects ; Quality of life ; Quality of Life - psychology ; Rash (Dermatology) ; Rehabilitation Medicine ; Side effects ; Skin ; Skin diseases ; Social Behavior ; Surveys and Questionnaires</subject><ispartof>Supportive care in cancer, 2010-03, Vol.18 (3), p.329-334</ispartof><rights>Springer-Verlag 2009</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-3bf7921a2ae73fafb18bf9e16fd02777eaa16a4c2949e91a7a3e436ad12288a43</citedby><cites>FETCH-LOGICAL-c503t-3bf7921a2ae73fafb18bf9e16fd02777eaa16a4c2949e91a7a3e436ad12288a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-009-0656-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-009-0656-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19484487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romito, Francesca</creatorcontrib><creatorcontrib>Giuliani, Francesco</creatorcontrib><creatorcontrib>Cormio, Claudia</creatorcontrib><creatorcontrib>Tulipani, Cinzia</creatorcontrib><creatorcontrib>Mattioli, Vittorio</creatorcontrib><creatorcontrib>Colucci, Giuseppe</creatorcontrib><title>Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Goals of work
Advanced colorectal cancer (CRC) has recently been treated with monoclonal antibodies, such as cetuximab. Skin toxicity is a peculiar side effect of cetuximab that may induce patients to interrupt therapy if it becomes serious. This study investigates the psychological and social sequelae of skin rash.
Materials and methods
Patients affected by advanced CRC and treated with cetuximab-based therapy entered the trial. The following questionnaires were used: the Functional Assessment of Cancer Therapy—Colorectal (FACT-C) to measure quality of life (QoL) and the Psychological Distress Inventory (PDI). A single item regarding social avoidance was added with a three-point Likert scale. Toxicity was assessed using the National Cancer Institute Criteria (NCI-2).
Main results
Eighty patients were recruited; 41% presented psychological distress. As regards social avoidance, 53% of patients answered that they did not avoid going out at all. The rest of the sample answered that they “very much” (22%) or “somewhat” (25%) avoided going out. Psychological distress and social avoidance were not correlated to skin rash, but only to QoL.
Conclusion
Skin rash was not found to impact patients' psychological status or social life. Two likely explanations for this finding were that (a) patients with advanced cancer consider skin rash as a part of the complex suffering caused by cancer and (b) patients are encouraged by oncologists to continue treatment because skin rash is indicative of response to therapy. This expectation brings hope and helps patients bear the drug-related side effects.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal - adverse effects</subject><subject>Antibodies, Monoclonal, Humanized</subject><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Anxiety - psychology</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Cetuximab</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Drug Eruptions - etiology</subject><subject>Drug Eruptions - psychology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Personality Inventory</subject><subject>Population Surveillance - methods</subject><subject>Psychological aspects</subject><subject>Quality of life</subject><subject>Quality of Life - psychology</subject><subject>Rash (Dermatology)</subject><subject>Rehabilitation Medicine</subject><subject>Side effects</subject><subject>Skin</subject><subject>Skin diseases</subject><subject>Social Behavior</subject><subject>Surveys and Questionnaires</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU-LFDEQxYMo7rj6AbxIo-es-dvpHJdFXWFBD3qO1enKbJaZZEy6Zffbm7EHFkHJIVD1e68qeYS85uyCM2beV8a0YJQxS1mve2qfkA1XUlIjpX1KNswqTpXU-oy8qPWOMW6MFs_JGbdqUGowG_Lja33wt3mXt9HDrsMQ0M-1y6HzOC_3cQ8jjWlaPE6dX2ZImJfaFai3XUwdTL8g_Wk1h9KUzcIfK6U7wBwxzfUleRZgV_HV6T4n3z9--HZ1TW--fPp8dXlDvWZypnIMxgoOAtDIAGHkwxgs8j5MTBhjEID3oLywyqLlYECikj1MXIhhACXPydvV91DyzwXr7O7yUlIb6YbeKqV7Yxv0boW2sEMXU8hzAb-P1btLqQemB26HRl38g2pnwn30OWGIrf6XgK8CX3KtBYM7lPZz5cFx5o5JuTUp15Jyx6TccZU3p32XcY_To-IUTQPECtTWSlssjw_6v-tvUKyeIQ</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Romito, Francesca</creator><creator>Giuliani, Francesco</creator><creator>Cormio, Claudia</creator><creator>Tulipani, Cinzia</creator><creator>Mattioli, Vittorio</creator><creator>Colucci, Giuseppe</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20100301</creationdate><title>Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients</title><author>Romito, Francesca ; Giuliani, Francesco ; Cormio, Claudia ; Tulipani, Cinzia ; Mattioli, Vittorio ; Colucci, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-3bf7921a2ae73fafb18bf9e16fd02777eaa16a4c2949e91a7a3e436ad12288a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Monoclonal - adverse effects</topic><topic>Antibodies, Monoclonal, Humanized</topic><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Anxiety - psychology</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Cetuximab</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Drug Eruptions - etiology</topic><topic>Drug Eruptions - psychology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Personality Inventory</topic><topic>Population Surveillance - methods</topic><topic>Psychological aspects</topic><topic>Quality of life</topic><topic>Quality of Life - psychology</topic><topic>Rash (Dermatology)</topic><topic>Rehabilitation Medicine</topic><topic>Side effects</topic><topic>Skin</topic><topic>Skin diseases</topic><topic>Social Behavior</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romito, Francesca</creatorcontrib><creatorcontrib>Giuliani, Francesco</creatorcontrib><creatorcontrib>Cormio, Claudia</creatorcontrib><creatorcontrib>Tulipani, Cinzia</creatorcontrib><creatorcontrib>Mattioli, Vittorio</creatorcontrib><creatorcontrib>Colucci, Giuseppe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romito, Francesca</au><au>Giuliani, Francesco</au><au>Cormio, Claudia</au><au>Tulipani, Cinzia</au><au>Mattioli, Vittorio</au><au>Colucci, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>18</volume><issue>3</issue><spage>329</spage><epage>334</epage><pages>329-334</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Goals of work
Advanced colorectal cancer (CRC) has recently been treated with monoclonal antibodies, such as cetuximab. Skin toxicity is a peculiar side effect of cetuximab that may induce patients to interrupt therapy if it becomes serious. This study investigates the psychological and social sequelae of skin rash.
Materials and methods
Patients affected by advanced CRC and treated with cetuximab-based therapy entered the trial. The following questionnaires were used: the Functional Assessment of Cancer Therapy—Colorectal (FACT-C) to measure quality of life (QoL) and the Psychological Distress Inventory (PDI). A single item regarding social avoidance was added with a three-point Likert scale. Toxicity was assessed using the National Cancer Institute Criteria (NCI-2).
Main results
Eighty patients were recruited; 41% presented psychological distress. As regards social avoidance, 53% of patients answered that they did not avoid going out at all. The rest of the sample answered that they “very much” (22%) or “somewhat” (25%) avoided going out. Psychological distress and social avoidance were not correlated to skin rash, but only to QoL.
Conclusion
Skin rash was not found to impact patients' psychological status or social life. Two likely explanations for this finding were that (a) patients with advanced cancer consider skin rash as a part of the complex suffering caused by cancer and (b) patients are encouraged by oncologists to continue treatment because skin rash is indicative of response to therapy. This expectation brings hope and helps patients bear the drug-related side effects.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19484487</pmid><doi>10.1007/s00520-009-0656-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antimitotic agents Antineoplastic agents Antineoplastic Agents - adverse effects Anxiety - psychology Cancer Cancer patients Care and treatment Cetuximab Colorectal cancer Colorectal Neoplasms - drug therapy Drug Eruptions - etiology Drug Eruptions - psychology Female Health aspects Humans Male Medicine Medicine & Public Health Middle Aged Monoclonal antibodies Nursing Nursing Research Oncology Original Article Pain Medicine Personality Inventory Population Surveillance - methods Psychological aspects Quality of life Quality of Life - psychology Rash (Dermatology) Rehabilitation Medicine Side effects Skin Skin diseases Social Behavior Surveys and Questionnaires |
| title | Psychological effects of cetuximab-induced cutaneous rash in advanced colorectal cancer patients |
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