Heated (37°C) oxaliplatin infusion in combination with capecitabine for metastatic colorectal carcinoma: can it reduce neuropathy?

Background/Purpose Oxaliplatin-associated neuropathy remains a dose-limiting toxicity of the standard chemotherapy regimen of oxaliplatin and capecitabine for metastatic colorectal cancer. No preventive strategy has definitively been established. Because this neuropathy is triggered by cold, we hypo...

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Veröffentlicht in:	Supportive care in cancer 2010-10, Vol.18 (10), p.1263-1270
Hauptverfasser:	Cathomas, Richard, Köberle, Dieter, Ruhstaller, Thomas, Mayer, Gisela, Räss, Andrea, Mey, Ulrich, von Moos, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Capecitabine Chemotherapy Clinical trials Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Feasibility Studies Female Fluorouracil - administration & dosage Fluorouracil - analogs & derivatives Heating Hot Temperature Humans Infusions, Intravenous Male Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Metastasis Neurological disorders Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - prevention & control Nursing Nursing Research Oncology Organoplatinum Compounds - administration & dosage Original Article Pain Medicine Pilot Projects Rehabilitation Medicine Time Factors Treatment Outcome
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