Identification of ultrasound contrast agent dilution systems for ejection fraction measurements
Left ventricular ejection fraction is an important cardiac-efficiency measure. Standard estimations are based on geometric analysis and modeling; they require time and experienced cardiologists. Alternative methods make use of indicator dilutions, but they are invasive due to the need for catheteriz...
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| Veröffentlicht in: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2005-03, Vol.52 (3), p.410-420 |
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| container_title | IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
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| creator | Mischi, M. Jansen, A.H.M. Kalker, A.A.C.M. Korsten, H.H.M. |
| description | Left ventricular ejection fraction is an important cardiac-efficiency measure. Standard estimations are based on geometric analysis and modeling; they require time and experienced cardiologists. Alternative methods make use of indicator dilutions, but they are invasive due to the need for catheterization. This study presents a new minimally invasive indicator dilution technique for ejection fraction quantification. It is based on a peripheral injection of an ultrasound contrast agent bolus. Left atrium and left ventricle acoustic intensities are recorded versus time by transthoracic echocardiography. The measured curves are corrected for attenuation distortion and processed by an adaptive Wiener deconvolution algorithm for the estimation of the left ventricle impulse response, which is interpolated by a monocompartment exponential model for the ejection fraction assessment. This technique measures forward ejection fraction, which excludes regurgitant volumes. The feasibility of the method was tested on a group of 20 patients with left ventricular ejection fractions going from 10% to 70%. The results are promising and show a 0.93 correlation coefficient with echographic bi-plane ejection fraction measurements. A more extensive validation as well as an investigation on the method applicability for valve insufficiency and right ventricular ejection fraction quantification will be an object of future study. |
| doi_str_mv | 10.1109/TUFFC.2005.1417263 |
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Standard estimations are based on geometric analysis and modeling; they require time and experienced cardiologists. Alternative methods make use of indicator dilutions, but they are invasive due to the need for catheterization. This study presents a new minimally invasive indicator dilution technique for ejection fraction quantification. It is based on a peripheral injection of an ultrasound contrast agent bolus. Left atrium and left ventricle acoustic intensities are recorded versus time by transthoracic echocardiography. The measured curves are corrected for attenuation distortion and processed by an adaptive Wiener deconvolution algorithm for the estimation of the left ventricle impulse response, which is interpolated by a monocompartment exponential model for the ejection fraction assessment. This technique measures forward ejection fraction, which excludes regurgitant volumes. The feasibility of the method was tested on a group of 20 patients with left ventricular ejection fractions going from 10% to 70%. The results are promising and show a 0.93 correlation coefficient with echographic bi-plane ejection fraction measurements. A more extensive validation as well as an investigation on the method applicability for valve insufficiency and right ventricular ejection fraction quantification will be an object of future study.</description><identifier>ISSN: 0885-3010</identifier><identifier>EISSN: 1525-8955</identifier><identifier>DOI: 10.1109/TUFFC.2005.1417263</identifier><identifier>PMID: 15857049</identifier><identifier>CODEN: ITUCER</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Acoustic measurements ; Algorithms ; Assessments ; Attenuation measurement ; Cardiology ; Catheterization ; Contrast agents ; Distortion measurement ; Echocardiography ; Echocardiography - methods ; Ejection ; Feasibility Studies ; Heart failure ; Heart Ventricles - diagnostic imaging ; Humans ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Impulse response ; Indicator Dilution Techniques ; Indicators ; Mathematical models ; Minimally invasive surgery ; Reproducibility of Results ; Sensitivity and Specificity ; Solid modeling ; Stroke Volume - physiology ; Ultrasonic imaging ; Ultrasonic variables measurement ; Ultrasound ; Ventricular Function</subject><ispartof>IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2005-03, Vol.52 (3), p.410-420</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-9fa3da5bf83b9a0e22d5e2cf8eb756cdc64d71e29b96d5a38da9ad59d27b545c3</citedby><cites>FETCH-LOGICAL-c455t-9fa3da5bf83b9a0e22d5e2cf8eb756cdc64d71e29b96d5a38da9ad59d27b545c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/1417263$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,778,782,794,27907,27908,54741</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/1417263$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15857049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mischi, M.</creatorcontrib><creatorcontrib>Jansen, A.H.M.</creatorcontrib><creatorcontrib>Kalker, A.A.C.M.</creatorcontrib><creatorcontrib>Korsten, H.H.M.</creatorcontrib><title>Identification of ultrasound contrast agent dilution systems for ejection fraction measurements</title><title>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</title><addtitle>T-UFFC</addtitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><description>Left ventricular ejection fraction is an important cardiac-efficiency measure. Standard estimations are based on geometric analysis and modeling; they require time and experienced cardiologists. Alternative methods make use of indicator dilutions, but they are invasive due to the need for catheterization. This study presents a new minimally invasive indicator dilution technique for ejection fraction quantification. It is based on a peripheral injection of an ultrasound contrast agent bolus. Left atrium and left ventricle acoustic intensities are recorded versus time by transthoracic echocardiography. The measured curves are corrected for attenuation distortion and processed by an adaptive Wiener deconvolution algorithm for the estimation of the left ventricle impulse response, which is interpolated by a monocompartment exponential model for the ejection fraction assessment. This technique measures forward ejection fraction, which excludes regurgitant volumes. The feasibility of the method was tested on a group of 20 patients with left ventricular ejection fractions going from 10% to 70%. The results are promising and show a 0.93 correlation coefficient with echographic bi-plane ejection fraction measurements. A more extensive validation as well as an investigation on the method applicability for valve insufficiency and right ventricular ejection fraction quantification will be an object of future study.</description><subject>Acoustic measurements</subject><subject>Algorithms</subject><subject>Assessments</subject><subject>Attenuation measurement</subject><subject>Cardiology</subject><subject>Catheterization</subject><subject>Contrast agents</subject><subject>Distortion measurement</subject><subject>Echocardiography</subject><subject>Echocardiography - methods</subject><subject>Ejection</subject><subject>Feasibility Studies</subject><subject>Heart failure</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Impulse response</subject><subject>Indicator Dilution Techniques</subject><subject>Indicators</subject><subject>Mathematical models</subject><subject>Minimally invasive surgery</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Solid modeling</subject><subject>Stroke Volume - physiology</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic variables measurement</subject><subject>Ultrasound</subject><subject>Ventricular Function</subject><issn>0885-3010</issn><issn>1525-8955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi1UBAvtH6ASinoopyz-yMT2Ea26LRISFzhbjj1GWSUxtZMD_57sbiSkHujJI8_zjuV5CLlidM0Y1bdPz9vtZs0phTWrmOS1OCErBhxKpQG-kBVVCkpBGT0nFznvKGVVpfkZOWegQNJKr4i59ziMbWidHds4FDEUUzcmm-M0-MLFYV-PhX2ZqcK33XSg8lsesc9FiKnAHbrDZUj2WPRo85SwnyP5KzkNtsv4bTkvyfP219PmT_nw-Pt-c_dQugpgLHWwwltoghKNthQ594DcBYWNhNp5V1deMuS60bUHK5S32nrQnssGKnDiktwc576m-HfCPJq-zQ67zg4Yp2w0lXreUC1m8uenZC2lBiHhvyCXWtdUVDP44x9wF6c0zN81qtaMcq32z_Ij5FLMOWEwr6ntbXozjJq9TnPQafY6zaJzDl0vk6emR_8RWfzNwPcj0CLiR3uJvwO3paYO</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Mischi, M.</creator><creator>Jansen, A.H.M.</creator><creator>Kalker, A.A.C.M.</creator><creator>Korsten, H.H.M.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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Standard estimations are based on geometric analysis and modeling; they require time and experienced cardiologists. Alternative methods make use of indicator dilutions, but they are invasive due to the need for catheterization. This study presents a new minimally invasive indicator dilution technique for ejection fraction quantification. It is based on a peripheral injection of an ultrasound contrast agent bolus. Left atrium and left ventricle acoustic intensities are recorded versus time by transthoracic echocardiography. The measured curves are corrected for attenuation distortion and processed by an adaptive Wiener deconvolution algorithm for the estimation of the left ventricle impulse response, which is interpolated by a monocompartment exponential model for the ejection fraction assessment. This technique measures forward ejection fraction, which excludes regurgitant volumes. The feasibility of the method was tested on a group of 20 patients with left ventricular ejection fractions going from 10% to 70%. The results are promising and show a 0.93 correlation coefficient with echographic bi-plane ejection fraction measurements. A more extensive validation as well as an investigation on the method applicability for valve insufficiency and right ventricular ejection fraction quantification will be an object of future study.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>15857049</pmid><doi>10.1109/TUFFC.2005.1417263</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2005-03, Vol.52 (3), p.410-420 |
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| subjects | Acoustic measurements Algorithms Assessments Attenuation measurement Cardiology Catheterization Contrast agents Distortion measurement Echocardiography Echocardiography - methods Ejection Feasibility Studies Heart failure Heart Ventricles - diagnostic imaging Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional - methods Impulse response Indicator Dilution Techniques Indicators Mathematical models Minimally invasive surgery Reproducibility of Results Sensitivity and Specificity Solid modeling Stroke Volume - physiology Ultrasonic imaging Ultrasonic variables measurement Ultrasound Ventricular Function |
| title | Identification of ultrasound contrast agent dilution systems for ejection fraction measurements |
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