Osteochondromas after Total-Body Irradiation
To the Editor: A 9-year-old boy received the diagnosis of acute biphenotypic leukemia. Once remission was induced, treatment proceeded to bone marrow transplantation with donation from the child's HLA-identical sister. The patient received total-body irradiation consisting of four fractions of...
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| Veröffentlicht in: | The New England journal of medicine 2011-02, Vol.364 (7), p.687-688 |
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| container_title | The New England journal of medicine |
| container_volume | 364 |
| creator | Matthys, Marisa K Benson, Jane E |
| description | To the Editor:
A 9-year-old boy received the diagnosis of acute biphenotypic leukemia. Once remission was induced, treatment proceeded to bone marrow transplantation with donation from the child's HLA-identical sister. The patient received total-body irradiation consisting of four fractions of 300 cGy for a total dose of 1200 cGy.
The patient did well initially, but at the age of 14 years, the leukemia relapsed. At the staging workup, he was found to have bilateral osteochondromas, benign tumors composed of bone projecting from endochondral bones, in the iliac wings. On the right side, one lesion had posterior projection, and on the . . . |
| doi_str_mv | 10.1056/NEJMc1012367 |
| format | Article |
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A 9-year-old boy received the diagnosis of acute biphenotypic leukemia. Once remission was induced, treatment proceeded to bone marrow transplantation with donation from the child's HLA-identical sister. The patient received total-body irradiation consisting of four fractions of 300 cGy for a total dose of 1200 cGy.
The patient did well initially, but at the age of 14 years, the leukemia relapsed. At the staging workup, he was found to have bilateral osteochondromas, benign tumors composed of bone projecting from endochondral bones, in the iliac wings. On the right side, one lesion had posterior projection, and on the . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc1012367</identifier><identifier>PMID: 21323561</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - etiology ; Child ; Humans ; Ilium - diagnostic imaging ; Leukemia, Biphenotypic, Acute - radiotherapy ; Male ; Neoplasms, Radiation-Induced - diagnostic imaging ; Osteochondroma - diagnostic imaging ; Osteochondroma - etiology ; Radiography ; Recurrence ; Whole-Body Irradiation - adverse effects</subject><ispartof>The New England journal of medicine, 2011-02, Vol.364 (7), p.687-688</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-898882b7f4c11c0aeafdb1766eb70d909f40c7c6c0e3ea4cd2625110fafe011e3</citedby><cites>FETCH-LOGICAL-c352t-898882b7f4c11c0aeafdb1766eb70d909f40c7c6c0e3ea4cd2625110fafe011e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc1012367$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/868663490?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21323561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matthys, Marisa K</creatorcontrib><creatorcontrib>Benson, Jane E</creatorcontrib><title>Osteochondromas after Total-Body Irradiation</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
A 9-year-old boy received the diagnosis of acute biphenotypic leukemia. Once remission was induced, treatment proceeded to bone marrow transplantation with donation from the child's HLA-identical sister. The patient received total-body irradiation consisting of four fractions of 300 cGy for a total dose of 1200 cGy.
The patient did well initially, but at the age of 14 years, the leukemia relapsed. At the staging workup, he was found to have bilateral osteochondromas, benign tumors composed of bone projecting from endochondral bones, in the iliac wings. On the right side, one lesion had posterior projection, and on the . . .</description><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - etiology</subject><subject>Child</subject><subject>Humans</subject><subject>Ilium - diagnostic imaging</subject><subject>Leukemia, Biphenotypic, Acute - radiotherapy</subject><subject>Male</subject><subject>Neoplasms, Radiation-Induced - diagnostic imaging</subject><subject>Osteochondroma - diagnostic imaging</subject><subject>Osteochondroma - etiology</subject><subject>Radiography</subject><subject>Recurrence</subject><subject>Whole-Body Irradiation - adverse effects</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkL1PwzAQRy0EoqWwMaMKMTZwZzuOM0JVoKjQpcyW4w_RqomLnQ797wlqQQzccsvT-0mPkEuEW4Rc3L1NXl4NAlImiiPSx5yxjHMQx6QPQGXGi5L1yFlKK-gOeXlKehQZZbnAPhnNU-uC-QiNjaHWaah96-JwEVq9zh6C3Q2nMWq71O0yNOfkxOt1cheHPyDvj5PF-DmbzZ-m4_tZZlhO20yWUkpaFZ4bRAPaaW8rLIRwVQG2hNJzMIURBhxzmhtLBc0RwWvvANGxAbneezcxfG5datUqbGPTTSoppBCMl9BBoz1kYkgpOq82cVnruFMI6ruM-lumw68Ozm1VO_sL_6TogJs9UNdJNW5V_-_5AheGZ8U</recordid><startdate>20110217</startdate><enddate>20110217</enddate><creator>Matthys, Marisa K</creator><creator>Benson, Jane E</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20110217</creationdate><title>Osteochondromas after Total-Body Irradiation</title><author>Matthys, Marisa K ; Benson, Jane E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-898882b7f4c11c0aeafdb1766eb70d909f40c7c6c0e3ea4cd2625110fafe011e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - etiology</topic><topic>Child</topic><topic>Humans</topic><topic>Ilium - diagnostic imaging</topic><topic>Leukemia, Biphenotypic, Acute - radiotherapy</topic><topic>Male</topic><topic>Neoplasms, Radiation-Induced - diagnostic imaging</topic><topic>Osteochondroma - diagnostic imaging</topic><topic>Osteochondroma - etiology</topic><topic>Radiography</topic><topic>Recurrence</topic><topic>Whole-Body Irradiation - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matthys, Marisa K</creatorcontrib><creatorcontrib>Benson, Jane E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matthys, Marisa K</au><au>Benson, Jane E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteochondromas after Total-Body Irradiation</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2011-02-17</date><risdate>2011</risdate><volume>364</volume><issue>7</issue><spage>687</spage><epage>688</epage><pages>687-688</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>To the Editor:
A 9-year-old boy received the diagnosis of acute biphenotypic leukemia. Once remission was induced, treatment proceeded to bone marrow transplantation with donation from the child's HLA-identical sister. The patient received total-body irradiation consisting of four fractions of 300 cGy for a total dose of 1200 cGy.
The patient did well initially, but at the age of 14 years, the leukemia relapsed. At the staging workup, he was found to have bilateral osteochondromas, benign tumors composed of bone projecting from endochondral bones, in the iliac wings. On the right side, one lesion had posterior projection, and on the . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>21323561</pmid><doi>10.1056/NEJMc1012367</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Bone Neoplasms - diagnostic imaging Bone Neoplasms - etiology Child Humans Ilium - diagnostic imaging Leukemia, Biphenotypic, Acute - radiotherapy Male Neoplasms, Radiation-Induced - diagnostic imaging Osteochondroma - diagnostic imaging Osteochondroma - etiology Radiography Recurrence Whole-Body Irradiation - adverse effects |
| title | Osteochondromas after Total-Body Irradiation |
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