Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats
We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animal...
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| Veröffentlicht in: | Kidney international 2011-06, Vol.79 (11), p.1186-1197 |
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| creator | Rouse, Rodney L. Zhang, Jun Stewart, Sharron R. Rosenzweig, Barry A. Espandiari, Parvaneh Sadrieh, Nakissa K. |
| description | We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed during dosing or over the following 42 days. Between days one and three, all biomarkers except albumin were elevated, peaked at day 7, and returned to control levels by day 10 (μ- and α-glutathione S-transferases, and renal papillary antigen-1) or day 15 (kidney injury molecule-1, lipocalin-2, osteopontin, and clusterin). All biomarkers performed better during injury than during recovery except osteopontin, which performed equally well in both time periods. During the evolution of injury, kidney injury molecule-1, renal papillary antigen-1, and clusterin best mirrored the histopathologic lesions. During injury resolution, kidney injury molecule-1, osteopontin, and blood urea nitrogen best reflected recovery. Based on histopathology, necrosis, or apoptosis scoring, kidney injury molecule-1 was the best biomarker of overall renal injury. Evaluation by regeneration score showed that renal papillary antigen-1 best reflected tubular and/or collecting duct regeneration, especially during recovery. Thus, these biomarkers performed with different effectiveness when evaluated by individual pathological processes such as necrosis, apoptosis, and regeneration. |
| doi_str_mv | 10.1038/ki.2010.463 |
| format | Article |
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The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed during dosing or over the following 42 days. Between days one and three, all biomarkers except albumin were elevated, peaked at day 7, and returned to control levels by day 10 (μ- and α-glutathione S-transferases, and renal papillary antigen-1) or day 15 (kidney injury molecule-1, lipocalin-2, osteopontin, and clusterin). All biomarkers performed better during injury than during recovery except osteopontin, which performed equally well in both time periods. During the evolution of injury, kidney injury molecule-1, renal papillary antigen-1, and clusterin best mirrored the histopathologic lesions. During injury resolution, kidney injury molecule-1, osteopontin, and blood urea nitrogen best reflected recovery. Based on histopathology, necrosis, or apoptosis scoring, kidney injury molecule-1 was the best biomarker of overall renal injury. Evaluation by regeneration score showed that renal papillary antigen-1 best reflected tubular and/or collecting duct regeneration, especially during recovery. Thus, these biomarkers performed with different effectiveness when evaluated by individual pathological processes such as necrosis, apoptosis, and regeneration.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.2010.463</identifier><identifier>PMID: 21150870</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>Basingstoke: Elsevier Inc</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - pathology ; Acute Kidney Injury - physiopathology ; Acute Kidney Injury - urine ; Animals ; Apoptosis ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - urine ; Cell Adhesion Molecules - urine ; Clusterin - urine ; gene expression ; Gentamicins ; Glutathione Transferase - urine ; histopathology ; Immunohistochemistry ; Kidney Tubules, Proximal - metabolism ; Kidney Tubules, Proximal - pathology ; Kidney Tubules, Proximal - physiopathology ; Lipocalins - urine ; Male ; Medical sciences ; Necrosis ; Nephrology. Urinary tract diseases ; Osteopontin - urine ; Predictive Value of Tests ; Proteomics - methods ; proximal tubule ; Rats ; Rats, Sprague-Dawley ; Reagent Kits, Diagnostic ; Regeneration ; renal injury ; ROC Curve ; Time Factors ; urine proteomics</subject><ispartof>Kidney international, 2011-06, Vol.79 (11), p.1186-1197</ispartof><rights>2011 International Society of Nephrology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 1, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-b5f202c9f97afd4e23e6df5045f6f3edc5fa55e24348290e93a07a198a70d0473</citedby><cites>FETCH-LOGICAL-c518t-b5f202c9f97afd4e23e6df5045f6f3edc5fa55e24348290e93a07a198a70d0473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/868644257?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24189451$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21150870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rouse, Rodney L.</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Stewart, Sharron R.</creatorcontrib><creatorcontrib>Rosenzweig, Barry A.</creatorcontrib><creatorcontrib>Espandiari, Parvaneh</creatorcontrib><creatorcontrib>Sadrieh, Nakissa K.</creatorcontrib><title>Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed during dosing or over the following 42 days. Between days one and three, all biomarkers except albumin were elevated, peaked at day 7, and returned to control levels by day 10 (μ- and α-glutathione S-transferases, and renal papillary antigen-1) or day 15 (kidney injury molecule-1, lipocalin-2, osteopontin, and clusterin). All biomarkers performed better during injury than during recovery except osteopontin, which performed equally well in both time periods. During the evolution of injury, kidney injury molecule-1, renal papillary antigen-1, and clusterin best mirrored the histopathologic lesions. During injury resolution, kidney injury molecule-1, osteopontin, and blood urea nitrogen best reflected recovery. Based on histopathology, necrosis, or apoptosis scoring, kidney injury molecule-1 was the best biomarker of overall renal injury. Evaluation by regeneration score showed that renal papillary antigen-1 best reflected tubular and/or collecting duct regeneration, especially during recovery. Thus, these biomarkers performed with different effectiveness when evaluated by individual pathological processes such as necrosis, apoptosis, and regeneration.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute Kidney Injury - physiopathology</subject><subject>Acute Kidney Injury - urine</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Cell Adhesion Molecules - urine</subject><subject>Clusterin - urine</subject><subject>gene expression</subject><subject>Gentamicins</subject><subject>Glutathione Transferase - urine</subject><subject>histopathology</subject><subject>Immunohistochemistry</subject><subject>Kidney Tubules, Proximal - metabolism</subject><subject>Kidney Tubules, Proximal - pathology</subject><subject>Kidney Tubules, Proximal - physiopathology</subject><subject>Lipocalins - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Osteopontin - urine</subject><subject>Predictive Value of Tests</subject><subject>Proteomics - methods</subject><subject>proximal tubule</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reagent Kits, Diagnostic</subject><subject>Regeneration</subject><subject>renal injury</subject><subject>ROC Curve</subject><subject>Time Factors</subject><subject>urine proteomics</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkLuP1DAQhy0E4paDih4sJCqUw888SrTiJZ1EA7XltcdoNomz2MlKW_Gv4yjL0VBZY38zP89HyEvO7jiT7fse7wQrharlI7LjWsiKN1o_JjvGWl0JLdsb8iznIyt1J9lTciM416xt2I783k_jySY74xnoKU0BB6BToG4aR0gO7TBcqD1bHOyhvCwJo00XesBptKmHlCnG0gduwIjODtSn5WeF0S8OPO3RR7gU5LiUJhs9LeR0hrTe0ZKan5MnwQ4ZXlzPW_Lj08fv-y_V_bfPX_cf7iuneTtXBx0EE64LXWODVyAk1D5opnSogwTvdLBag1BStaJj0EnLGsu71jbMM9XIW_Jmm1t2_LVAns1xWlIskaat21opoVfo3Qa5NOWcIJhTwrLnxXBmVtemR7O6NsV1oV9dRy6HEfwD-1duAd5eAZuLmpBsdJj_cYq3ndK8cK83Ltp5SfAA9LhmbVF6I6AoOiMkkx1CLIqxCJ2Nn_C_X_wDEKildQ</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Rouse, Rodney L.</creator><creator>Zhang, Jun</creator><creator>Stewart, Sharron R.</creator><creator>Rosenzweig, Barry A.</creator><creator>Espandiari, Parvaneh</creator><creator>Sadrieh, Nakissa K.</creator><general>Elsevier Inc</general><general>Nature Publishing Group</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20110601</creationdate><title>Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats</title><author>Rouse, Rodney L. ; Zhang, Jun ; Stewart, Sharron R. ; Rosenzweig, Barry A. ; Espandiari, Parvaneh ; Sadrieh, Nakissa K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-b5f202c9f97afd4e23e6df5045f6f3edc5fa55e24348290e93a07a198a70d0473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - pathology</topic><topic>Acute Kidney Injury - physiopathology</topic><topic>Acute Kidney Injury - urine</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Cell Adhesion Molecules - urine</topic><topic>Clusterin - urine</topic><topic>gene expression</topic><topic>Gentamicins</topic><topic>Glutathione Transferase - urine</topic><topic>histopathology</topic><topic>Immunohistochemistry</topic><topic>Kidney Tubules, Proximal - metabolism</topic><topic>Kidney Tubules, Proximal - pathology</topic><topic>Kidney Tubules, Proximal - physiopathology</topic><topic>Lipocalins - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Osteopontin - urine</topic><topic>Predictive Value of Tests</topic><topic>Proteomics - methods</topic><topic>proximal tubule</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reagent Kits, Diagnostic</topic><topic>Regeneration</topic><topic>renal injury</topic><topic>ROC Curve</topic><topic>Time Factors</topic><topic>urine proteomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rouse, Rodney L.</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Stewart, Sharron R.</creatorcontrib><creatorcontrib>Rosenzweig, Barry A.</creatorcontrib><creatorcontrib>Espandiari, Parvaneh</creatorcontrib><creatorcontrib>Sadrieh, Nakissa K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rouse, Rodney L.</au><au>Zhang, Jun</au><au>Stewart, Sharron R.</au><au>Rosenzweig, Barry A.</au><au>Espandiari, Parvaneh</au><au>Sadrieh, Nakissa K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>79</volume><issue>11</issue><spage>1186</spage><epage>1197</epage><pages>1186-1197</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed during dosing or over the following 42 days. Between days one and three, all biomarkers except albumin were elevated, peaked at day 7, and returned to control levels by day 10 (μ- and α-glutathione S-transferases, and renal papillary antigen-1) or day 15 (kidney injury molecule-1, lipocalin-2, osteopontin, and clusterin). All biomarkers performed better during injury than during recovery except osteopontin, which performed equally well in both time periods. During the evolution of injury, kidney injury molecule-1, renal papillary antigen-1, and clusterin best mirrored the histopathologic lesions. During injury resolution, kidney injury molecule-1, osteopontin, and blood urea nitrogen best reflected recovery. Based on histopathology, necrosis, or apoptosis scoring, kidney injury molecule-1 was the best biomarker of overall renal injury. Evaluation by regeneration score showed that renal papillary antigen-1 best reflected tubular and/or collecting duct regeneration, especially during recovery. Thus, these biomarkers performed with different effectiveness when evaluated by individual pathological processes such as necrosis, apoptosis, and regeneration.</abstract><cop>Basingstoke</cop><pub>Elsevier Inc</pub><pmid>21150870</pmid><doi>10.1038/ki.2010.463</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - pathology Acute Kidney Injury - physiopathology Acute Kidney Injury - urine Animals Apoptosis Biological and medical sciences Biomarkers - blood Biomarkers - urine Cell Adhesion Molecules - urine Clusterin - urine gene expression Gentamicins Glutathione Transferase - urine histopathology Immunohistochemistry Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - pathology Kidney Tubules, Proximal - physiopathology Lipocalins - urine Male Medical sciences Necrosis Nephrology. Urinary tract diseases Osteopontin - urine Predictive Value of Tests Proteomics - methods proximal tubule Rats Rats, Sprague-Dawley Reagent Kits, Diagnostic Regeneration renal injury ROC Curve Time Factors urine proteomics |
| title | Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats |
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