Lipoprotein(a) identifies cardiovascular risk in childhood: The Australian Aboriginal Birth Cohort Study
Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children. Methods: A cross‐sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal...
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| Veröffentlicht in: | Journal of paediatrics and child health 2011-05, Vol.47 (5), p.257-261 |
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| creator | Cunningham, Teresa E Sayers, Susan M Singh, Gurmeet R |
| description | Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.
Methods: A cross‐sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re‐examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.
Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well‐known lipid‐based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non‐genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.
Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor. |
| doi_str_mv | 10.1111/j.1440-1754.2010.01955.x |
| format | Article |
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Methods: A cross‐sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re‐examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.
Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well‐known lipid‐based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non‐genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.
Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.</description><identifier>ISSN: 1034-4810</identifier><identifier>ISSN: 1440-1754</identifier><identifier>EISSN: 1440-1754</identifier><identifier>DOI: 10.1111/j.1440-1754.2010.01955.x</identifier><identifier>PMID: 21244559</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Aboriginal ; Aboriginal children ; Aboriginal health ; Age ; Anthropometry ; Australia ; Biomarkers ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - ethnology ; cardiovascular risk factor ; Child ; Children ; Children & youth ; Cholesterol ; Cohort Studies ; Cross-Sectional Studies ; Diseases ; Female ; Historical account ; Humans ; indigenous ; Indigenous peoples ; lipoprotein(a) ; Lipoprotein(a) - blood ; Lipoproteins ; Male ; Native peoples ; Northern Territory ; Nutrition ; Risk ; Risk Factors ; Smoking ; Territory</subject><ispartof>Journal of paediatrics and child health, 2011-05, Vol.47 (5), p.257-261</ispartof><rights>2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians)</rights><rights>2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5575-5807d46c8acf0a99abad0e2aaec9dcb9b5464b876bcfbdec83c3d3e4c35d3df23</citedby><cites>FETCH-LOGICAL-c5575-5807d46c8acf0a99abad0e2aaec9dcb9b5464b876bcfbdec83c3d3e4c35d3df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1754.2010.01955.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1754.2010.01955.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21244559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cunningham, Teresa E</creatorcontrib><creatorcontrib>Sayers, Susan M</creatorcontrib><creatorcontrib>Singh, Gurmeet R</creatorcontrib><title>Lipoprotein(a) identifies cardiovascular risk in childhood: The Australian Aboriginal Birth Cohort Study</title><title>Journal of paediatrics and child health</title><addtitle>J Paediatr Child Health</addtitle><description>Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.
Methods: A cross‐sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re‐examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.
Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well‐known lipid‐based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non‐genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.
Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.</description><subject>Aboriginal</subject><subject>Aboriginal children</subject><subject>Aboriginal health</subject><subject>Age</subject><subject>Anthropometry</subject><subject>Australia</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>cardiovascular risk factor</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cholesterol</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diseases</subject><subject>Female</subject><subject>Historical account</subject><subject>Humans</subject><subject>indigenous</subject><subject>Indigenous peoples</subject><subject>lipoprotein(a)</subject><subject>Lipoprotein(a) - blood</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Native peoples</subject><subject>Northern Territory</subject><subject>Nutrition</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Territory</subject><issn>1034-4810</issn><issn>1440-1754</issn><issn>1440-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-P1CAYhxujcdfVr2CIF_XQEQq01MTDOHF3NRM1cf0TL28o0C2znTIC1ZlvL51Z5-BFuUB4n98TyC_LEMEzktaL1YwwhnNScTYrcLrFpOZ8tr2TnR4Hd9MZU5YzQfBJ9iCEFca44Fzcz04KUjDGeX2adUu7cRvvorHDM_kcWW2GaFtrAlLSa-t-yqDGXnrkbbhBdkCqs73unNMv0VVn0HwM0cveygHNG-fttR1kj15bHzu0cJ3zEX2Ko949zO61sg_m0e1-ln0-f3O1uMyXHy7eLubLXHFe8ZwLXGlWKiFVi2Vdy0ZqbAopjaq1auqGs5I1oiob1TbaKEEV1dQwRbmmui3oWfb04E2f-jGaEGFtgzJ9LwfjxgApWhQcF-zfZCloVQo-kU_-Ildu9OmfewiXWNRlgsQBUt6F4E0LG2_X0u-AYJhagxVM5cBUDkytwb412Kbo41v_2KyNPgb_1JSAVwfgl-3N7r_F8O7jYjql_Pkh79c2gtzINkIX4yaAllGCHVq3nzh_DdrZSUwpKcGaPsGTk-C6KEgS5QeRDdFsjw-R_gbKilYcvr6_gEvxrf7C-Xdg9DeRM87X</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Cunningham, Teresa E</creator><creator>Sayers, Susan M</creator><creator>Singh, Gurmeet R</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201105</creationdate><title>Lipoprotein(a) identifies cardiovascular risk in childhood: The Australian Aboriginal Birth Cohort Study</title><author>Cunningham, Teresa E ; Sayers, Susan M ; Singh, Gurmeet R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5575-5807d46c8acf0a99abad0e2aaec9dcb9b5464b876bcfbdec83c3d3e4c35d3df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aboriginal</topic><topic>Aboriginal children</topic><topic>Aboriginal health</topic><topic>Age</topic><topic>Anthropometry</topic><topic>Australia</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>cardiovascular risk factor</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cholesterol</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diseases</topic><topic>Female</topic><topic>Historical account</topic><topic>Humans</topic><topic>indigenous</topic><topic>Indigenous peoples</topic><topic>lipoprotein(a)</topic><topic>Lipoprotein(a) - blood</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Native peoples</topic><topic>Northern Territory</topic><topic>Nutrition</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Territory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cunningham, Teresa E</creatorcontrib><creatorcontrib>Sayers, Susan M</creatorcontrib><creatorcontrib>Singh, Gurmeet R</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of paediatrics and child health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cunningham, Teresa E</au><au>Sayers, Susan M</au><au>Singh, Gurmeet R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein(a) identifies cardiovascular risk in childhood: The Australian Aboriginal Birth Cohort Study</atitle><jtitle>Journal of paediatrics and child health</jtitle><addtitle>J Paediatr Child Health</addtitle><date>2011-05</date><risdate>2011</risdate><volume>47</volume><issue>5</issue><spage>257</spage><epage>261</epage><pages>257-261</pages><issn>1034-4810</issn><issn>1440-1754</issn><eissn>1440-1754</eissn><abstract>Aim: To describe the lipoprotein(a) (Lp(a) )profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.
Methods: A cross‐sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re‐examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.
Results: At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well‐known lipid‐based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non‐genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.
Conclusions: Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>21244559</pmid><doi>10.1111/j.1440-1754.2010.01955.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of paediatrics and child health, 2011-05, Vol.47 (5), p.257-261 |
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| subjects | Aboriginal Aboriginal children Aboriginal health Age Anthropometry Australia Biomarkers Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - ethnology cardiovascular risk factor Child Children Children & youth Cholesterol Cohort Studies Cross-Sectional Studies Diseases Female Historical account Humans indigenous Indigenous peoples lipoprotein(a) Lipoprotein(a) - blood Lipoproteins Male Native peoples Northern Territory Nutrition Risk Risk Factors Smoking Territory |
| title | Lipoprotein(a) identifies cardiovascular risk in childhood: The Australian Aboriginal Birth Cohort Study |
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