A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

Sebastian Bonhoeffer, Christos Petropoulos and colleagues report a systems analysis of the fitness landscape of HIV-1 protease and reverse transcriptase. They use a dataset of over 70,000 virus samples, isolated from HIV-1 subtype B infected individuals, assayed for in vitro replicative capacity alo...

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Veröffentlicht in:	Nature genetics 2011-05, Vol.43 (5), p.487-489
Hauptverfasser:	Hinkley, Trevor, Martins, João, Chappey, Colombe, Haddad, Mojgan, Stawiski, Eric, Whitcomb, Jeannette M, Petropoulos, Christos J, Bonhoeffer, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 631/326/22/1434 631/553/1472 692/699/255/1901 Agriculture Amino acids Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Drug resistance Drug Resistance, Viral - genetics Epistasis, Genetic Evolution Fundamental and applied biological sciences. Psychology Gene Function Genes, Viral Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Health aspects HIV (Viruses) HIV Protease - chemistry HIV Protease - genetics HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology Human Genetics Humans letter Methods Models, Genetic Models, Molecular Mutation Parameter estimation Physiological aspects Regression Analysis Reverse transcriptase Studies Systems Analysis Virus Replication - drug effects Virus Replication - genetics
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