Sequence Specific Label-Free DNA Sensing Using Film-Bulk-Acoustic-Resonators
A label-free biosensor (for detection of DNA sequences) based on film-bulk-acoustic-resonator (FBAR) is presented in this letter. The FBAR's resonant frequency shifts to a lower value when a complementary single-strand DNA sequence is hybridized with a DNA probe sequence on an Au-coated FBAR su...
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| Veröffentlicht in: | IEEE sensors journal 2007-12, Vol.7 (12), p.1587-1588 |
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| container_title | IEEE sensors journal |
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| creator | Hao Zhang Marma, M.S. Bahl, S.K. Eun Sok Kim McKenna, C.E. |
| description | A label-free biosensor (for detection of DNA sequences) based on film-bulk-acoustic-resonator (FBAR) is presented in this letter. The FBAR's resonant frequency shifts to a lower value when a complementary single-strand DNA sequence is hybridized with a DNA probe sequence on an Au-coated FBAR surface. The sensor is capable of distinguishing a complementary DNA that is mismatched to a probe DNA by a single nucleotide. The label-free, highly sensitive and selective, and real-time detection of DNA sequence could easily be made into an array for combinatory DNA sequencing, and could possibly help geneticists to detect specific DNA sequences accurately and fast, without any expensive optical scanning or imaging. |
| doi_str_mv | 10.1109/JSEN.2007.905035 |
| format | Article |
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The FBAR's resonant frequency shifts to a lower value when a complementary single-strand DNA sequence is hybridized with a DNA probe sequence on an Au-coated FBAR surface. The sensor is capable of distinguishing a complementary DNA that is mismatched to a probe DNA by a single nucleotide. 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(IEEE) 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-e9efb25006c1d742deffa43cfe44c1d67c3a55495098183e90008a31f0b376e43</citedby><cites>FETCH-LOGICAL-c385t-e9efb25006c1d742deffa43cfe44c1d67c3a55495098183e90008a31f0b376e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/4373312$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27901,27902,54733</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/4373312$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Hao Zhang</creatorcontrib><creatorcontrib>Marma, M.S.</creatorcontrib><creatorcontrib>Bahl, S.K.</creatorcontrib><creatorcontrib>Eun Sok Kim</creatorcontrib><creatorcontrib>McKenna, C.E.</creatorcontrib><title>Sequence Specific Label-Free DNA Sensing Using Film-Bulk-Acoustic-Resonators</title><title>IEEE sensors journal</title><addtitle>JSEN</addtitle><description>A label-free biosensor (for detection of DNA sequences) based on film-bulk-acoustic-resonator (FBAR) is presented in this letter. The FBAR's resonant frequency shifts to a lower value when a complementary single-strand DNA sequence is hybridized with a DNA probe sequence on an Au-coated FBAR surface. The sensor is capable of distinguishing a complementary DNA that is mismatched to a probe DNA by a single nucleotide. The label-free, highly sensitive and selective, and real-time detection of DNA sequence could easily be made into an array for combinatory DNA sequencing, and could possibly help geneticists to detect specific DNA sequences accurately and fast, without any expensive optical scanning or imaging.</description><subject>Biomedical optical imaging</subject><subject>Biosensor</subject><subject>Biosensors</subject><subject>DNA</subject><subject>DNA hybridization</subject><subject>Film bulk acoustic resonators</subject><subject>film-bulk-acoustic-resonator (FBAR)</subject><subject>mass sensor</subject><subject>Optical arrays</subject><subject>Optical films</subject><subject>Optical sensors</subject><subject>Probes</subject><subject>Resonant frequency</subject><subject>Sequences</subject><issn>1530-437X</issn><issn>1558-1748</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNqFkT1PwzAQhiMEEqWwI7FEDDC5nHN2bI-ltHyoKhKlEpuVuheUkiYlbgf-PQ5FDAywnE_Wc6f39ETRKYce52CuHqbDSS8BUD0DElDuRR0upWZcCb3f9ghMoHo5jI68XwJwo6TqROMpvW-pchRP1-SKvHDxOJtTyUYNUXwz6cdTqnxRvcazrzoqyhW73pZvrO_qrd8Ujj2Rr6tsUzf-ODrIs9LTyffbjWaj4fPgjo0fb-8H_TFzqOWGkaF8nkiA1PGFEsmC8jwT6HISIvykymEmpTASjOYayQCAzpDnMEeVksBudLnbu27qkN5v7KrwjsoyqyiEsgYwFSpVyb-k1pAaRKEDefEniULIFDQG8PwXuKy3TRXutToV0oTQ7TbYQa6pvW8ot-umWGXNh-VgW1-29WVbX3bnK4yc7UYKIvrBgzJEnuAnljaOxA</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Hao Zhang</creator><creator>Marma, M.S.</creator><creator>Bahl, S.K.</creator><creator>Eun Sok Kim</creator><creator>McKenna, C.E.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>F28</scope><scope>FR3</scope><scope>7TM</scope></search><sort><creationdate>200712</creationdate><title>Sequence Specific Label-Free DNA Sensing Using Film-Bulk-Acoustic-Resonators</title><author>Hao Zhang ; Marma, M.S. ; Bahl, S.K. ; Eun Sok Kim ; McKenna, C.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-e9efb25006c1d742deffa43cfe44c1d67c3a55495098183e90008a31f0b376e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biomedical optical imaging</topic><topic>Biosensor</topic><topic>Biosensors</topic><topic>DNA</topic><topic>DNA hybridization</topic><topic>Film bulk acoustic resonators</topic><topic>film-bulk-acoustic-resonator (FBAR)</topic><topic>mass sensor</topic><topic>Optical arrays</topic><topic>Optical films</topic><topic>Optical sensors</topic><topic>Probes</topic><topic>Resonant frequency</topic><topic>Sequences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao Zhang</creatorcontrib><creatorcontrib>Marma, M.S.</creatorcontrib><creatorcontrib>Bahl, S.K.</creatorcontrib><creatorcontrib>Eun Sok Kim</creatorcontrib><creatorcontrib>McKenna, C.E.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Nucleic Acids Abstracts</collection><jtitle>IEEE sensors journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hao Zhang</au><au>Marma, M.S.</au><au>Bahl, S.K.</au><au>Eun Sok Kim</au><au>McKenna, C.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence Specific Label-Free DNA Sensing Using Film-Bulk-Acoustic-Resonators</atitle><jtitle>IEEE sensors journal</jtitle><stitle>JSEN</stitle><date>2007-12</date><risdate>2007</risdate><volume>7</volume><issue>12</issue><spage>1587</spage><epage>1588</epage><pages>1587-1588</pages><issn>1530-437X</issn><eissn>1558-1748</eissn><coden>ISJEAZ</coden><abstract>A label-free biosensor (for detection of DNA sequences) based on film-bulk-acoustic-resonator (FBAR) is presented in this letter. The FBAR's resonant frequency shifts to a lower value when a complementary single-strand DNA sequence is hybridized with a DNA probe sequence on an Au-coated FBAR surface. The sensor is capable of distinguishing a complementary DNA that is mismatched to a probe DNA by a single nucleotide. The label-free, highly sensitive and selective, and real-time detection of DNA sequence could easily be made into an array for combinatory DNA sequencing, and could possibly help geneticists to detect specific DNA sequences accurately and fast, without any expensive optical scanning or imaging.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSEN.2007.905035</doi><tpages>2</tpages></addata></record> |
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| language | eng |
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| source | IEEE Electronic Library (IEL) |
| subjects | Biomedical optical imaging Biosensor Biosensors DNA DNA hybridization Film bulk acoustic resonators film-bulk-acoustic-resonator (FBAR) mass sensor Optical arrays Optical films Optical sensors Probes Resonant frequency Sequences |
| title | Sequence Specific Label-Free DNA Sensing Using Film-Bulk-Acoustic-Resonators |
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