Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis

Purpose Oral mucositis (OM) is a frequent side effect in patients with cancer. We investigate the effect of atorvastatin (ATV), a cholesterol-lowering drug, on OM induced by 5-fluorouracil (5-FU) in hamsters. Methods OM was induced by the i.p. administration of 5-FU, with excoriations of the cheek p...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2011-05, Vol.67 (5), p.1085-1100
Hauptverfasser:	Medeiros, C. A. C. X., Leitão, R. F. C., Macedo, R. N., Barboza, D. R. M. M., Gomes, A. S., Nogueira, N. A. P., Alencar, N. M. N., Ribeiro, R. A., Brito, G. A. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Antimetabolites, Antineoplastic - toxicity Antineoplastic agents Atorvastatin Calcium Bacteremia - chemically induced Bacteremia - microbiology Biological and medical sciences Cancer Research Chemical and Drug Induced Liver Injury - etiology Cricetinae Cytokines - metabolism Dose-Response Relationship, Drug Facial bones, jaws, teeth, parodontium: diseases, semeiology Fluorouracil - toxicity Heptanoic Acids - adverse effects Heptanoic Acids - therapeutic use Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Leukopenia - chemically induced Male Medical sciences Medicine Medicine & Public Health Mesocricetus Mouth Mucosa - drug effects Mouth Mucosa - pathology Nitric Oxide Synthase Type II - metabolism Nitrites - metabolism Non tumoral diseases Oncology Original Article Otorhinolaryngology. Stomatology Peroxidase - metabolism Pharmacology. Drug treatments Pharmacology/Toxicology Pyrroles - adverse effects Pyrroles - therapeutic use Stomatitis - chemically induced Stomatitis - drug therapy Stomatitis - pathology Sulfhydryl Compounds - metabolism
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